Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Beatriz Levy-Wilson"'
Publikováno v:
Biochemistry. 40:6731-6742
The 5' boundary of the chromosomal domain of the human apolipoprotein B (apoB) gene in intestinal cells has been localized and characterized. It is composed of two kinds of boundary elements; the first, functional boundary is an insulator activity ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e546c12bd1caa732fe130dfabc79669c
https://doi.org/10.1021/bi0100743
https://doi.org/10.1021/bi0100743
Publikováno v:
Molecular Cell Biology Research Communications. 4:206-211
A number of DNaseI-hypersensitive (DH) sites have been mapped within a regulatory region situated upstream of the human apolipoprotein B (apoB) promoter (−5262 to −899) that is required for high level expression of human apoB transgenes in the li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b07b6e21cb72ff1b808e726a642b7ba2
https://doi.org/10.1006/mcbr.2001.0279
https://doi.org/10.1006/mcbr.2001.0279
Publikováno v:
Journal of Biological Chemistry. 275:26649-26660
To date, the molecular mechanisms that govern hepatic-specific transcription of the human cholesterol 7alpha-hydroxylase (CYP7A1) gene are poorly understood. We recently reported that the region extending from -1888 to +46, which includes the promote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83f1452d7a423de289a14aa0b87d02b7
https://doi.org/10.1074/jbc.m002852200
https://doi.org/10.1074/jbc.m002852200
Autor:
Meghan Sullivan, Beatriz Levy-Wilson, Travis J. Antes, Stephen G. Young, Cathy Huynh, Sheryl A. Goodart
Publikováno v:
Journal of Biological Chemistry. 275:26637-26648
We recently reported that an 8-kilobase (kb) region, spanning from -54 to -62 kb 5' of the human apolipoprotein B (apoB) gene, contains intestine-specific regulatory elements that control apoB expression in the intestines of transgenic mice. In this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::384c2adf33917c94b46a32ccad8e892b
https://doi.org/10.1074/jbc.m003025200
https://doi.org/10.1074/jbc.m003025200
Publikováno v:
Biochemical and Biophysical Research Communications. 260:829-834
Cholesterol 7α-hydroxylase (CYP7A1), a liver-specific enzyme, catalyzes the rate-limiting step in the degradation pathway of cholesterol to bile acids, and thus plays a key role in cholesterol homeostasis. To elucidate the mechanisms that control he
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f54616ca27cb15d32dcb73728cdf9950
https://doi.org/10.1006/bbrc.1999.0980
https://doi.org/10.1006/bbrc.1999.0980
Autor:
Jean Chen, Mary Jane Botelho-Yetkinler, Beatriz Levy-Wilson, Yicheng Cao, Allen D. Cooper, Takahiro Taniguchi
Publikováno v:
Journal of Biological Chemistry. 272:3444-3452
Cholesterol 7alpha-hydroxylase is the rate-limiting enzyme in the degradation of cholesterol to bile salts and plays a central role in regulating cholesterol homeostasis. The mechanisms involved in the transcriptional control of the human gene are la
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bb0d2eaab6b34d13a5b61a796f885e7d
https://doi.org/10.1074/jbc.272.6.3444
https://doi.org/10.1074/jbc.272.6.3444
Publikováno v:
The Journal of biological chemistry. 277(45)
Cholesterol 7alpha-hydroxylase (CYP7A1) catalyzes the rate-limiting step in the pathway responsible for the formation of the majority of bile acids. Transcription of the gene is regulated by the size of the bile acid pool and dietary and hormonal fac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4252da4091b041a48e339c3e617d2cc1
https://pubmed.ncbi.nlm.nih.gov/12202481
https://pubmed.ncbi.nlm.nih.gov/12202481
Publikováno v:
Biochemistry. 40(23)
Recently, we reported that a 315 bp enhancer, located over 55 kilobases (kb) upstream of the transcriptional start site of the human apolipoprotein B (apoB) gene, was sufficient to direct high-level expression of human apoB transgenes in mice. In thi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c5d17ce8d042ebd611313282c547262
https://pubmed.ncbi.nlm.nih.gov/11389586
https://pubmed.ncbi.nlm.nih.gov/11389586
Autor:
Beatriz Levy-Wilson, Travis J. Antes
Publikováno v:
DNA and cell biology. 20(2)
Recently, we identified a 315-bp intestinal enhancer (IE), localized over 55 kb upstream from the transcriptional start of the human apolipoprotein B (apoB) gene, that confers expression of human apoB transgenes in the intestines of mice. Four functi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a683a24c650cc9da12cb3ea55e5c83dd
https://pubmed.ncbi.nlm.nih.gov/11244563
https://pubmed.ncbi.nlm.nih.gov/11244563
Publikováno v:
Biochemical and biophysical research communications. 266(2)
We have generated transgenic mice expressing human CYP7A1 transgenes. Only 1.5 kilobases (kb) of 5' upstream sequence and 6.5 kb of 3' sequence were sufficient for hepatic transcription of the transgenes. However, the 5' end segment alone was not suf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7efc573b9777362cfc9c73c7f7a6ea93
https://pubmed.ncbi.nlm.nih.gov/10600524
https://pubmed.ncbi.nlm.nih.gov/10600524