Zobrazeno 1 - 10
of 72
pro vyhledávání: '"Beatriz Ibarra"'
Autor:
Gloria Gamiz-Arco, Luis I. Gutierrez-Rus, Valeria A. Risso, Beatriz Ibarra-Molero, Yosuke Hoshino, Dušan Petrović, Jose Justicia, Juan Manuel Cuerva, Adrian Romero-Rivera, Burckhard Seelig, Jose A. Gavira, Shina C. L. Kamerlin, Eric A. Gaucher, Jose M. Sanchez-Ruiz
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Family 1 glycosidases (GH1) are present in the three domains of life and share classical TIM-barrel fold. Structural and biochemical analyses of a resurrected ancestral GH1 enzyme reveal heme binding, not known in its modern descendants. Heme rigidif
Externí odkaz:
https://doaj.org/article/16437a6b7b904e66bc65cf7320d77917
Autor:
Luis A. Campos, Rajendra Sharma, Sara Alvira, Federico M. Ruiz, Beatriz Ibarra-Molero, Mourad Sadqi, Carlos Alfonso, Germán Rivas, Jose M. Sanchez-Ruiz, Antonio Romero Garrido, José M. Valpuesta, Victor Muñoz
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
The design of protein assemblies is a major thrust for biomolecular engineering and nanobiotechnology. Here the authors demonstrate a general mechanism for designing allosteric macromolecular assemblies and showcase a proof of concept for engineered
Externí odkaz:
https://doaj.org/article/35fa5f2626334f038b8530ed1e35e4fe
Autor:
Raquel Luzon-Hidalgo, Valeria A. Risso, Asuncion Delgado, Beatriz Ibarra-Molero, Jose M. Sanchez-Ruiz
Publikováno v:
STAR Protocols, Vol 2, Iss 3, Pp 100784- (2021)
Summary: A general protocol for the experimental assessment of bacteriophage adaptation to new hosts is described. We use as a model system the lytic phage T7 and an engineered E. coli strain modified to hamper the recruitment of a known proviral fac
Externí odkaz:
https://doaj.org/article/8ac9745717c94e5a83f153721e6e9dea
Autor:
Raquel Luzon-Hidalgo, Valeria A. Risso, Asuncion Delgado, Eduardo Andrés-León, Beatriz Ibarra-Molero, Jose M. Sanchez-Ruiz
Publikováno v:
iScience, Vol 24, Iss 4, Pp 102257- (2021)
Summary: Viruses interact extensively with the host molecular machinery, but the underlying mechanisms are poorly understood. Bacteriophage T7 recruits the small protein thioredoxin of the Escherichia coli host as an essential processivity factor for
Externí odkaz:
https://doaj.org/article/ebfa3d63ed2a44cc9ab8f8bd7fcc5edd
Publikováno v:
Cell Reports, Vol 19, Iss 6, Pp 1247-1256 (2017)
Proviral factors are host proteins hijacked by viruses for processes essential for virus propagation such as cellular entry and replication. Pathogens and their hosts co-evolve. It follows that replacing a proviral factor with a functional ancestral
Externí odkaz:
https://doaj.org/article/0ac099a9744d445981be9f8c30d2e368
Autor:
Nathaniel K. Mullin, Nikhil V. Mallipeddi, Emily Hamburg-Shields, Beatriz Ibarra, Ahmad M. Khalil, Radhika P. Atit
Publikováno v:
Frontiers in Genetics, Vol 8 (2017)
Wnt/β-catenin signaling is required for embryonic dermal fibroblast cell fate, and dysregulation of this pathway is sufficient to promote fibrosis in adult tissue. The downstream modulators of Wnt/β-catenin signaling required for controlling cell f
Externí odkaz:
https://doaj.org/article/7d4b9bbc3efb401685ce67f75ea07d18
Autor:
M Luisa Romero-Romero, Valeria A Risso, Sergio Martinez-Rodriguez, Eric A Gaucher, Beatriz Ibarra-Molero, Jose M Sanchez-Ruiz
Publikováno v:
PLoS ONE, Vol 11, Iss 6, p e0156657 (2016)
The relationship between the denaturation temperatures of proteins (Tm values) and the living temperatures of their host organisms (environmental temperatures: TENV values) is poorly understood. Since different proteins in the same organism may show
Externí odkaz:
https://doaj.org/article/76b7332af96f4d04a68449fad49c4d98
Publikováno v:
PLoS Computational Biology, Vol 8, Iss 6, p e1002558 (2012)
Protein promiscuity is of considerable interest due its role in adaptive metabolic plasticity, its fundamental connection with molecular evolution and also because of its biotechnological applications. Current views on the relation between primary an
Externí odkaz:
https://doaj.org/article/ad045bea8a064d159b51dbd119bf1093
Publikováno v:
PLoS ONE, Vol 6, Iss 7, p e23050 (2011)
Despite several careful experimental analyses, it is not yet clear whether protein cold-denaturation is just a "mirror image" of heat denaturation or whether it shows unique structural and energetic features. Here we report that, for a well-character
Externí odkaz:
https://doaj.org/article/8204758871fe412cab7028bf73469461
Autor:
Beatriz Ibarra-Mendoza, Bruno Gomez-Gil, Miguel Betancourt-Lozano, Luciana Raggi, Beatriz Yáñez-Rivera
Publikováno v:
Gut Microbiome, Pp 1-24
Externí odkaz:
https://doaj.org/article/ad08aca5608b47c49891bbf6ad923ced