Mechanisms underlying TARP modulation of the GluA1/2-γ8 AMPA receptor

Autor: Beatriz Herguedas, Bianka K. Kohegyi, Jan-Niklas Dohrke, Jake F. Watson, Danyang Zhang, Hinze Ho, Saher A. Shaikh, Remigijus Lape, James M. Krieger, Ingo H. Greger

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)

AMPA glutamate receptors, mediate the majority of excitatory signaling in the brain. Here the authors show how the auxiliary subunit TARP-γ8 shapes gating kinetics, ion conductance and rectification properties of the heteromeric GluA1/2 AMPA recepto

Externí odkaz: https://doaj.org/article/f9368cca10774546b0cd1cadbb36dc6e

Mapping the Interaction Sites between AMPA Receptors and TARPs Reveals a Role for the Receptor N-Terminal Domain in Channel Gating

Autor: Ondrej Cais, Beatriz Herguedas, Karolina Krol, Stuart G. Cull-Candy, Mark Farrant, Ingo H. Greger

Publikováno v: Cell Reports, Vol 9, Iss 2, Pp 728-740 (2014)

AMPA-type glutamate receptors (AMPARs) mediate fast neurotransmission at excitatory synapses. The extent and fidelity of postsynaptic depolarization triggered by AMPAR activation are shaped by AMPAR auxiliary subunits, including the transmembrane AMP

Externí odkaz: https://doaj.org/article/6a1e1169981048bfbc0552a473bbf56b

The dynamic AMPA receptor extracellular region: a platform for synaptic protein interactions

Autor: Ingo H. Greger, Jake F. Watson, Beatriz Herguedas, Javier García-Nafría

Publikováno v: The Journal of Physiology. 594:5449-5458

AMPA receptors (AMPARs) are glutamate-gated cation channels that mediate fast excitatory neurotransmission and synaptic plasticity. Structures of GluA2 homotetramers in distinct functional states, together with simulations, emphasise the loose archit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7bb22776b3d0e0f14bb9b840692d32cd
https://doi.org/10.1113/jp271844

Aromatic stacking interactions govern catalysis in aryl-alcohol oxidase

Autor: Ángel T. Martínez, Kenneth W. Borrelli, Victor Guallar, Patricia Ferreira, Aitor Hernández-Ortega, Milagros Medina, Juan Carro, Fátima Lucas, Beatriz Herguedas

Publikováno v: Recercat. Dipósit de la Recerca de Catalunya
instname
UPCommons. Portal del coneixement obert de la UPC
Universitat Politècnica de Catalunya (UPC)

This is the peer reviewed version of the following article: [Ferreira, P., Hernández-Ortega, A., Lucas, F., Carro, J., Herguedas, B., Borrelli, K. W., Guallar, V., Martínez, A. T. and Medina, M. (2015), Aromatic stacking interactions govern catalys

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72db102798f531510f9781a9435fdbb8
https://doi.org/10.1111/febs.13221

A hydrogen bond network in the active site of Anabaena ferredoxin-NADP+ reductase modulates its catalytic efficiency

Autor: José A. Navarro, Manuel Hervás, Marta Martínez-Júlvez, Ana Sánchez-Azqueta, Milagros Medina, Ramon Hurtado-Guerrero, Beatriz Herguedas

Publikováno v: idUS. Depósito de Investigación de la Universidad de Sevilla
instname
Digital.CSIC. Repositorio Institucional del CSIC

Ferredoxin-nicotinamide-adenine dinucleotide phosphate (NADP+) reductase (FNR) catalyses the production of reduced nicotinamide-adenine dinucleotide phosphate (NADPH) in photosynthetic organisms, where its flavin adenine dinucleotide (FAD) cofactor t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb4a7772d401d5e0ccc034f3dd15380a