PARP-1/PARP-2 double deficiency in mouse T cells results in faulty immune responses and T lymphomas

Autor: Beatriz Revilla-Nuin, Beatriz Gozalbo-López, Margarita Del Val, Sandra Segura-Bayona, José Yélamos, Philip A. Knobel, Andrea C. Méndez, Valérie Schreiber, Jordi Farrés, Carlos Martinez, Travis H. Stracker, Coral Ampurdanés, Françoise Dantzer, María F. Bueno, Juan Martín-Caballero, David M. Arana, Miguel Galindo-Campos, Pedro Aparicio, J.A. Navarro

Publikováno v: Scientific Reports
Digital.CSIC. Repositorio Institucional del CSIC
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Scientific Reports, Nature Publishing Group, 2017, 7, pp.41962. ⟨10.1038/srep41962⟩
Europe PubMed Central

The maintenance of T-cell homeostasis must be tightly regulated. Here, we have identified a coordinated role of Poly(ADP-ribose) polymerase-1 (PARP-1) and PARP-2 in maintaining T-lymphocyte number and function. Mice bearing a T-cell specific deficien

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea38903a9c22b5cb5936c5cfcec310a2
http://hdl.handle.net/10261/166308

Human MR1 expression on the cell surface is acid sensitive, proteasome independent and increases after culturing at 26°C

Autor: Eduardo Martínez-Naves, Vanesa Viana, Juan López-Relaño, Manuel Gómez del Moral, Beatriz Gozalbo-López, Beatriz Abós

Publikováno v: Biochemical and biophysical research communications. 411(3)

Mucosal-associated invariant T (MAIT) cells are a population of non-conventional T-lymphocytes which are restricted by the MHC-related 1 (MR1) molecule. MR1 is a non-classical member of the MHC class I family of proteins, it is unknown if MR1 present

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2965c2f9dbc34395b1ed82438c593bf
https://pubmed.ncbi.nlm.nih.gov/21777569

A Role for DNA Polymerase μ in the Emerging DJH Rearrangements of the Postgastrulation Mouse Embryo▿ †

Autor: Beatriz Gozalbo-López, Gloria Terrados, Belén de Andrés, Beatriz Palacios, Isabel Cortegano, Paula B. Andrade, Miguel A. R. Marcos, María Luisa Gaspar, Luis Blanco, Antonio Bernad, Natalia Serrano

The molecular complexes involved in the nonhomologous end-joining process that resolves recombination-activating gene (RAG)-induced double-strand breaks and results in V(D)J gene rearrangements vary during mammalian ontogeny. In the mouse, the first

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abf334a23aa5c6334a0b7856b3c11cdf
https://europepmc.org/articles/PMC2643829/

Identification of a new mouse Cd1d2 allele

Autor: J. F. Parra‐Cuadrado, Eduardo Martínez-Naves, A. Pérez‐Rosado, Beatriz Gozalbo-López

Publikováno v: European journal of immunogenetics : official journal of the British Society for Histocompatibility and Immunogenetics. 31(1)

Summary The mouse CD1 system is formed by two closely related genes named Cd1d1 and Cd1d2. Cd1d1 encodes a molecule that presents antigens to NKT cells. The function of the Cd1d2 gene has not been elucidated. Here we described a method to analyse var

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0290d14d1d428dc0d1b56c3f3210965
https://pubmed.ncbi.nlm.nih.gov/15009173

Antagonistic effect of TNF-alpha and insulin on uncoupling protein 2 (UCP-2) expression and vascular damage

Autor: Almudena Gómez-Hernández, Beatriz Gozalbo-López, Vicente Lahera, Liliana Perdomo, Victoria Cachofeiro, Manuel Benito, Oscar Escribano, Sabela Díaz-Castroverde, Nuria Beneit, Natalia de las Heras, Carlos Guillén, Yolanda F. Otero

Publikováno v: Cardiovascular Diabetology

Background It has been reported that increased expression of UCP-2 in the vasculature may prevent the development of atherosclerosis in patients with increased production of reactive oxygen species, as in the diabetes, obesity or hypertension. Thus,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2618c58e14fb233385612760eee24f16