Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Beatriz Gomez Perez-Nievas"'
Autor:
Erica Staurenghi, Valentina Cerrato, Paola Gamba, Gabriella Testa, Serena Giannelli, Valerio Leoni, Claudio Caccia, Annalisa Buffo, Wendy Noble, Beatriz Gomez Perez-Nievas, Gabriella Leonarduzzi
Publikováno v:
Redox Biology, Vol 39, Iss , Pp 101837- (2021)
Among Alzheimer's disease (AD) brain hallmarks, the presence of reactive astrocytes was demonstrated to correlate with neuronal loss and cognitive deficits. Evidence indeed supports the role of reactive astrocytes as mediators of changes in neurons,
Externí odkaz:
https://doaj.org/article/f2828f617de545a1ae710d9a775e594c
Publikováno v:
Frontiers in Neurology, Vol 11 (2020)
Tauopathies are a group of neurodegenerative diseases characterized by the progressive accumulation across the brain of hyperphosphorylated aggregates of the microtubule-associated protein tau that vary in isoform composition, structural conformation
Externí odkaz:
https://doaj.org/article/6df5ed2df0b84d778981f786cf2896e0
Autor:
Peter Thornton, Jean Sevalle, Michael J Deery, Graham Fraser, Ye Zhou, Sara Ståhl, Elske H Franssen, Roger B Dodd, Seema Qamar, Beatriz Gomez Perez‐Nievas, Louise SC Nicol, Susanna Eketjäll, Jefferson Revell, Clare Jones, Andrew Billinton, Peter H St George‐Hyslop, Iain Chessell, Damian C Crowther
Publikováno v:
EMBO Molecular Medicine, Vol 9, Iss 10, Pp 1366-1378 (2017)
Abstract We have characterised the proteolytic cleavage events responsible for the shedding of triggering receptor expressed on myeloid cells 2 (TREM2) from primary cultures of human macrophages, murine microglia and TREM2‐expressing human embryoni
Externí odkaz:
https://doaj.org/article/c069149e8d3140e48dd7f555f57c2d71
Autor:
Fiona Kerr, Oyinkan Sofola-Adesakin, Dobril K Ivanov, Jemma Gatliff, Beatriz Gomez Perez-Nievas, Hélène C Bertrand, Pedro Martinez, Rebecca Callard, Inge Snoeren, Helena M Cochemé, Jennifer Adcott, Mobina Khericha, Jorge Iván Castillo-Quan, Geoffrey Wells, Wendy Noble, Janet Thornton, Linda Partridge
Publikováno v:
PLoS Genetics, Vol 13, Iss 3, p e1006593 (2017)
Nrf2, a transcriptional activator of cell protection genes, is an attractive therapeutic target for the prevention of neurodegenerative diseases, including Alzheimer's disease (AD). Current Nrf2 activators, however, may exert toxicity and pathway ove
Externí odkaz:
https://doaj.org/article/0da1b265333b4d3d89cda4194d8f09d6
Autor:
Vittoria Matafora, Alena Gorb, Wendy Noble, Angela Bachi, Beatriz Gomez Perez-Nievas, Maria Jimenez-Sanchez
Astrocytes associate with amyloid plaques in Alzheimer’s disease (AD). Astrocytes react to changes in the brain environment, including to increasing concentrations of amyloid-ß (Aß). However, the precise response of astrocytes to soluble small A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b724c636f2b4e554c6c769d435437c1b
https://doi.org/10.1101/2023.01.18.523916
https://doi.org/10.1101/2023.01.18.523916
Autor:
Beatriz Gomez Perez-Nievas
Publikováno v:
Nature Neuroscience. 26:725-725
Autor:
Beatriz Gomez Perez-Nievas
Publikováno v:
Nature Neuroscience. 26:534-534
Autor:
Beatriz Gomez Perez-Nievas
Publikováno v:
Nature Neuroscience. 26:365-365
Cysteine string protein alpha accumulates with early pre-synaptic dysfunction in Alzheimer’s disease
Autor:
Huzefa Rupawala, Keshvi Shah, Caitlin Davies, Jamie Rose, Marti Colom-Cadena, Xianhui Peng, Lucy Granat, Manal Aljuhani, Keiko Mizuno, Claire Troakes, Beatriz Gomez Perez-Nievas, Alan Morgan, Po-Wah So, Tibor Hortobagyi, Tara L Spires-Jones, Wendy Noble, Karl Peter Giese
Publikováno v:
Rupawala, H, Shah, K, Davies, C, Rose, J, Colom-Cadena, M, Peng, X, Granat, L, Aljuhani, M, Mizuno, K, Troakes, C, Perez-Nievas, B G, Morgan, A, So, P-W, Hortobagyi, T, Spires-Jones, T L, Noble, W & Giese, K P 2022, ' Cysteine string protein alpha accumulates with early pre-synaptic dysfunction in Alzheimer's disease ', Brain Communications, vol. 4, no. 4, fcac192, pp. fcac192 . https://doi.org/10.1093/braincomms/fcac192
Brain communications
Brain communications
In Alzheimer’s disease, synapse loss causes memory and cognitive impairment. However, the mechanisms underlying synaptic degeneration in Alzheimer’s disease are not well understood. In the hippocampus, alterations in the level of cysteine string
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1c969cb1de3bf9724f960761798cc4c
Autor:
Erica Staurenghi, Valentina Cerrato, Paola Gamba, Gabriella Testa, Serena Giannelli, Valerio Leoni, Claudio Caccia, Annalisa Buffo, Wendy Noble, Beatriz Gomez Perez-Nievas, Gabriella Leonarduzzi
Background: Among Alzheimer’s disease (AD) brain hallmarks, the presence of reactive astrocytes was demonstrated to correlate with neuronal loss and cognitive deficits. Evidence indeed supports the role of reactive astrocytes as mediators of change
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5eb4bef170581fa6e7e152de4fb1810a
https://doi.org/10.21203/rs.3.rs-52307/v1
https://doi.org/10.21203/rs.3.rs-52307/v1