Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Beatriz Garcillán"'
Autor:
Md Ashik Ullah, Beatriz Garcillán, Eden Whitlock, William A. Figgett, Simona Infantino, Mahya Eslami, SiLing Yang, M. Arifur Rahman, Yong H. Sheng, Nicholas Weber, Pascal Schneider, Constantine S. Tam, Fabienne Mackay
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
BackgroundChronic Lymphocytic Leukemia (CLL) is characterized by the expansion of CD19+ CD5+ B cells but its origin remains debated. Mutated CLL may originate from post-germinal center B cells and unmutated CLL from CD5+ mature B cell precursors. Irr
Externí odkaz:
https://doaj.org/article/947282a58a244f7ab452eed5a10ac908
Autor:
Beatriz Garcillán, Rebeca F. Megino, Marta Herrero-Alonso, Alberto C. Guardo, Veronica Perez-Flores, Claudia Juraske, Vincent Idstein, Jose M. Martin-Fernandez, Carsten Geisler, Wolfgang W. A. Schamel, Ana V. Marin, Jose R. Regueiro
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
The CD3 subunits of the T-cell antigen receptor (TCR) play a central role in regulation of surface TCR expression levels. Humans who lack CD3γ (γ—) show reduced surface TCR expression levels and abolished phorbol ester (PMA)-induced TCR down-regu
Externí odkaz:
https://doaj.org/article/ee3075c5866d4f45b4af9db868d1fc27
Autor:
Beatriz Garcillán, Patricia Fuentes, Ana V. Marin, Rebeca F. Megino, Daniel Chacon-Arguedas, Marina S. Mazariegos, Anaïs Jiménez-Reinoso, Miguel Muñoz-Ruiz, Raquel G. Laborda, Paula P. Cárdenas, Edgar Fernández-Malavé, Maria L. Toribio, José R. Regueiro
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
The human αβ T-cell receptor (TCR) is composed of a variable heterodimer (TCRαβ) and three invariant dimers (CD3γε, CD3δε, and ζζ/CD2472). The role of each invariant chain in the stepwise interactions among TCR chains along the assembly is
Externí odkaz:
https://doaj.org/article/f22f1ad542f849088084b9af82e689f6
Publikováno v:
Vaccines, Vol 10, Iss 2, p 297 (2022)
Patients with immune-mediated inflammatory diseases (IMIDs), such as rheumatoid arthritis and inflammatory bowel disease, are at increased risk of infection. International guidelines recommend vaccination to limit this risk of infection, although liv
Externí odkaz:
https://doaj.org/article/8db123ad60384c78874b64c84ea1aa26
Autor:
Maria Auladell, Thi Ho Nguyen, Beatriz Garcillán, Fabienne Mackay, Katherine Kedzierska, Annette Fox
Publikováno v:
Clinical & Translational Immunology, Vol 8, Iss 11, Pp n/a-n/a (2019)
Abstract Objectives A fundamental question in influenza research is whether antibody titre decline upon successive exposure to variant strains is consequent to recall of cross‐reactive memory B cells that competitively inhibit naive B‐cell respon
Externí odkaz:
https://doaj.org/article/1c122513c3a04093844d2c1f0281af6e
Autor:
Elaine P. Dopfer, Frederike A. Hartl, Hans-Heinrich Oberg, Gabrielle M. Siegers, O. Sascha Yousefi, Sylvia Kock, Gina J. Fiala, Beatriz Garcillán, Andrew Sandstrom, Balbino Alarcón, Jose R. Regueiro, Dieter Kabelitz, Erin J. Adams, Susana Minguet, Daniela Wesch, Paul Fisch, Wolfgang W.A. Schamel
Publikováno v:
Cell Reports, Vol 7, Iss 5, Pp 1704-1715 (2014)
Activation of the T cell receptor (TCR) by antigen is the key step in adaptive immunity. In the αβTCR, antigen induces a conformational change at the CD3 subunits (CD3 CC) that is absolutely required for αβTCR activation. Here, we demonstrate tha
Externí odkaz:
https://doaj.org/article/d96a71cd8e9c4d03be71b8194bfc3b6e
Autor:
Ana V. Marin, Daniel Chacon-Arguedas, Anaïs Jiménez-Reinoso, Miguel Muñoz-Ruiz, Raquel G. Laborda, Paula P. Cárdenas, Edgar Fernández-Malavé, Marina S. Mazariegos, Patricia Fuentes, Rebeca F. Megino, María L. Toribio, Beatriz Garcillán, José R. Regueiro
Publikováno v:
E-Prints Complutense. Archivo Institucional de la UCM
instname
Digital.CSIC. Repositorio Institucional del CSIC
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Frontiers in Cell and Developmental Biology
instname
Digital.CSIC. Repositorio Institucional del CSIC
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Frontiers in Cell and Developmental Biology
The human αβ T-cell receptor (TCR) is composed of a variable heterodimer (TCRαβ) and three invariant dimers (CD3γε, CD3δε, and ζζ/CD247). The role of each invariant chain in the stepwise interactions among TCR chains along the assembly is s
Publikováno v:
Immunology and Cell Biology. 96:453-462
Altered B-cell homeostasis underlies a wide range of pathologies, from cancers to autoimmunity and immunodeficiency. The molecular safeguards against those disorders, which also allow effective immune responses, are therefore particularly critical. H
Autor:
Annette Fox, Thi H. O. Nguyen, Katherine Kedzierska, Fabienne Mackay, Maria Auladell, Beatriz Garcillán
Publikováno v:
Clinical & Translational Immunology
Clinical & Translational Immunology, Vol 8, Iss 11, Pp n/a-n/a (2019)
Clinical & Translational Immunology, Vol 8, Iss 11, Pp n/a-n/a (2019)
Objectives A fundamental question in influenza research is whether antibody titre decline upon successive exposure to variant strains is consequent to recall of cross‐reactive memory B cells that competitively inhibit naive B‐cell responses. In c
Autor:
Ana V.M. Marin, Beatriz Garcillán, Anaïs Jiménez-Reinoso, Miguel Muñoz-Ruiz, Alejandro C. Briones, Edgar Fernández-Malavé, Maria J. Recio, José R. Regueiro
Publikováno v:
LymphoSign Journal. 2:3-19
Immunodeficiencies of most T-cell receptor (TCR) components (TCRID) have been reported in almost 40 patients worldwide who have also, at times, shown signs of autoimmunity. We updated their clinical, immunological, and molecular features with an emph