Zobrazeno 1 - 10
of 321
pro vyhledávání: '"Beatriz G de la Torre"'
Autor:
Sikabwe Noki, Luana Lastella, Simona Serban, Alessandra Basso, Gyorgy Orosz, Beatriz G de la Torre, Fernando Albericio
Publikováno v:
Green Chemistry Letters and Reviews, Vol 18, Iss 1 (2025)
The free use of DMF has recently been restricted since December 2023 in Europe because of its health hazards. Over time, these restrictions will extend to the USA and other countries. As DMF is the solvent of choice for solid-phase peptide synthesis
Externí odkaz:
https://doaj.org/article/1702dc7c9761467f98f85cbeea37a6e3
Autor:
Mónica González-Magaldi, Ángela Vázquez-Calvo, Beatriz G de la Torre, Javier Valle, David Andreu, Francisco Sobrino
Publikováno v:
PLoS ONE, Vol 10, Iss 10, p e0141415 (2015)
Nonstructural protein 3A is involved in relevant functions in foot-and-mouth disease virus (FMDV) replication. FMDV 3A can form homodimers and preservation of the two hydrophobic α-helices (α1 and α2) that stabilize the dimer interface is essentia
Externí odkaz:
https://doaj.org/article/686df5c15ed64c4993422d2e1cd91ba5
Autor:
Clara L Oeste, Beatriz Díez-Dacal, Francesca Bray, Mario García de Lacoba, Beatriz G de la Torre, David Andreu, Antonio J Ruiz-Sánchez, Ezequiel Pérez-Inestrosa, Carlota A García-Domínguez, José M Rojas, Dolores Pérez-Sala
Publikováno v:
PLoS ONE, Vol 6, Iss 1, p e15866 (2011)
Ras proteins are crucial players in differentiation and oncogenesis and constitute important drug targets. The localization and activity of Ras proteins are highly dependent on posttranslational modifications at their C-termini. In addition to an iso
Externí odkaz:
https://doaj.org/article/712eb7985871462f8ee67f16db98aea7
Publikováno v:
Biomedicines, Vol 12, Iss 9, p 1992 (2024)
An increase in total drug (small molecules and biologics) approvals by the Food and Drug Administration (FDA) was seen in 2023 compared with the previous year. Cancer remained the disease most targeted by monoclonal antibodies (mAbs), followed by aut
Externí odkaz:
https://doaj.org/article/902e380c36ce4c5db7917634e9859827
Publikováno v:
Advanced Science, Vol 10, Iss 26, Pp n/a-n/a (2023)
Abstract Antimicrobial peptides (AMPs) are essential elements of thehost defense system. Characterized by heterogenous structures and broad‐spectrumaction, they are promising candidates for combating multidrug resistance. Thecombined use of AMPs wi
Externí odkaz:
https://doaj.org/article/15b6379146354c88bbeeca7d004f3ba2
Publikováno v:
Molecules, Vol 29, Iss 7, p 1429 (2024)
Solid-phase peptide synthesis (SPPS) is the preferred strategy for synthesizing most peptides for research purposes and on a multi-kilogram scale. One key to the success of SPPS is the continual evolution and improvement of the original method propos
Externí odkaz:
https://doaj.org/article/a2dba798e30b466fb2a67f9f6f1344eb
Publikováno v:
Pharmaceuticals, Vol 17, Iss 2, p 243 (2024)
A total of nine TIDES (pepTIDES and oligonucleoTIDES) were approved by the FDA during 2023. The four approved oligonucleotides are indicated for various types of disorders, including amyotrophic lateral sclerosis, geographic atrophy, primary hyperoxa
Externí odkaz:
https://doaj.org/article/4dae35486161477388f8e34c1bc7a62d
Publikováno v:
Molecules, Vol 29, Iss 3, p 585 (2024)
With the COVID-19 pandemic behind us, the U.S. Food and Drug Administration (FDA) has approved 55 new drugs in 2023, a figure consistent with the number authorized in the last five years (53 per year on average). Thus, 2023 marks the second-best year
Externí odkaz:
https://doaj.org/article/1b0c7f208783402f955c82eb9ed84ddd
Autor:
Tanya Román, Gerardo Acosta, Constanza Cárdenas, Beatriz G. de la Torre, Fanny Guzmán, Fernando Albericio
Publikováno v:
Methods and Protocols, Vol 6, Iss 6, p 110 (2023)
One approach to enhance the bioavailability and half-life of peptides in vivo is through N-methylation of one or more of the amino acids within the peptide sequence. However, commercially available Fmoc-N-Me-AA-OHs are limited and often expensive. In
Externí odkaz:
https://doaj.org/article/203517f06e2548ecb63761c5a85f4ebc
Autor:
Srinivasa Rao Manne, Anamika Sharma, Andrius Sazonovas, Ayman El-Faham, Beatriz G. de la Torre, Fernando Albericio
Publikováno v:
ACS Omega, Vol 7, Iss 7, Pp 6007-6023 (2022)
Externí odkaz:
https://doaj.org/article/8f761e0a3d654b2a9af2dd49eec143af