A conserved arginine with non‐conserved function is a key determinant of agonist selectivity in α7 nicotinic ACh receptors

Autor: Timothy Gallagher, Cecilia Gotti, Ana Sofia F Oliveira, Beatriz Elizabeth Nielsen, Richard B. Sessions, Isabel Bermudez, Adrian J. Mulholland, Teresa Minguez-Viñas, Cecilia Bouzat, Deborah K. Shoemark, Susan Wonnacott

Publikováno v: Minguez-Viñas, T, Nielsen, B E, Shoemark, D K, Gotti, C, Sessions, R B, Mulholland, A J, Bouzat, C, Wonnacott, S, Gallagher, T, Bermudez, I & Oliveira, A S 2021, ' A conserved arginine with non-conserved function is a key determinant of agonist selectivity in α7 nicotinic ACh receptors ', British Journal of Pharmacology, vol. 178, no. 7, pp. 1651-1668 . https://doi.org/10.1111/bph.15389
Minguez Viñas, T, Shoemark, D K, Sessions, R B, Mulholland, A J, Gallagher, T, Oliveira, A S & al., E 2021, ' A conserved arginine with non-conserved function is a key determinant of agonist selectivity in α7 nicotinic ACh receptors ', British Journal of Pharmacology, vol. 178, no. 7, pp. 1651-1668 . https://doi.org/10.1111/bph.15389

Background and PurposeThe α7 and α4β2* (“*” denotes possibly assembly with another subunit) nicotinic acetylcholine receptors (nAChRs) are the most abundant nAChRs in the mammalian brain. These receptors are the most targeted nAChRs in drug di

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49465823bbfc1af3116cfe62a1b97773
https://doi.org/10.1111/bph.15389

Molecular function of α7 nicotinic receptors as drug targets

Autor: María del Carmen Esandi, Cecilia Bouzat, Jeremias Corradi, Matías Marcelo Lasala, Beatriz Elizabeth Nielsen

Publikováno v: The Journal of Physiology. 596:1847-1861

Nicotinic acetylcholine receptors (nAChRs) are pentameric ligand-gated ion channels involved in many physiological and pathological processes. In vertebrates, there are seventeen different nAChR subunits that combine to yield a variety of receptors w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::06db57d5985add132211a7f534fb7095
https://doi.org/10.1113/jp275101

Exploring the positive allosteric modulation of human α7 nicotinic receptors from a single-channel perspective

Autor: Natalia Denise Andersen, Hugo R. Arias, Jeremias Corradi, Dominik Feuerbach, Beatriz Elizabeth Nielsen, María Fernanda Tolosa, Cecilia Bouzat

Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

Enhancement of α7 nicotinic receptor (nAChR) function by positive allosteric modulators (PAMs) is a promising therapeutic strategy to improve cognitive deficits. PAMs have been classified only on the basis of their macroscopic effects as type I, whi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb5ea644988926dcb33a0ba00f011184
https://doi.org/10.1016/j.neuropharm.2016.02.032