Biocatalytic C3-Indole Methylation-A Useful Tool for the Natural-Product-Inspired Stereoselective Synthesis of Pyrroloindoles

Autor: Benjamin P. Chapple, Beatrix Paschold, Pascal Schneider, Marcel Schatton, Thomas Classen, Florian P. Seebeck, Jörg Pietruszka, Birgit Henßen

Publikováno v: Angewandte Chemie / International edition 60(43), 23412-23418 (2021). doi:10.1002/anie.202107619
Angewandte Chemie (International Ed. in English)

Enantioselective synthesis of bioactive compounds bearing a pyrroloindole framework is often laborious. In contrast, there are several S‐adenosyl methionine (SAM)‐dependent methyl transferases known for stereo‐ and regioselective methylation at

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