Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Beatrix Gillet-Legrand"'
Autor:
Marie‐Stéphane Aigrot, Clara Barthelemy, Sarah Moyon, Gaelle Dufayet‐Chaffaud, Leire Izagirre‐Urizar, Beatrix Gillet‐Legrand, Satoru Tada, Laura Bayón‐Cordero, Juan‐Carlos Chara, Carlos Matute, Nathalie Cartier, Catherine Lubetzki, Vanja Tepavčević
Publikováno v:
EMBO Molecular Medicine, Vol 14, Iss 8, Pp 1-17 (2022)
Abstract Preventing neurodegeneration‐associated disability progression in patients with multiple sclerosis (MS) remains an unmet therapeutic need. As remyelination prevents axonal degeneration, promoting this process in patients might enhance neur
Externí odkaz:
https://doaj.org/article/c1839741b7e847299f847e6b2eb4852c
Autor:
Kurt A. Sailor, George Agoranos, Sergio López-Manzaneda, Satoru Tada, Beatrix Gillet-Legrand, Corentin Guerinot, Jean-Baptiste Masson, Christian L. Vestergaard, Melissa Bonner, Khatuna Gagnidze, Gabor Veres, Pierre-Marie Lledo, Nathalie Cartier
Publikováno v:
Nature Medicine
Nature Medicine, 2022, ⟨10.1038/s41591-022-01691-9⟩
Nature Medicine, 2022, ⟨10.1038/s41591-022-01691-9⟩
International audience; Hematopoietic stem cell transplantation (HSCT) is a therapy used for multiple malignant and nonmalignant diseases, with chemotherapy used for pretransplantation myeloablation. The post-HSCT brain contains peripheral engrafted
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2d2fbb2686bae310ff975bb4318d650
https://hal-pasteur.archives-ouvertes.fr/pasteur-03588683
https://hal-pasteur.archives-ouvertes.fr/pasteur-03588683
Autor:
Marie-Stephane Aigrot, Clara Barthelemy, Sarah Moyon, Gaelle Dufayet-Chaffaud, Leire Izagirre-Urizar, Beatrix Gillet-Legrand, Laura Bayón-Cordero, Satoru Tada, Juan-Carlos Chara, Carlos Matute, Nathalie Cartier, Catherine Lubetzki, Vanja Tepavčević
Preventing neurodegeneration-associated disability progression in patients with multiple sclerosis (MS) remains an unmet therapeutic need. As remyelination prevents degeneration of demyelinated axons, promoting this process in patients might halt the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::635d4a7e5d128e511bdb13b230ab6912
https://doi.org/10.1101/2020.10.28.358705
https://doi.org/10.1101/2020.10.28.358705
Autor:
Emilie Audouard, Nicolas Khefif, Béatrix Gillet-Legrand, Fanny Nobilleau, Ouafa Bouazizi, Serena Stanga, Gaëtan Despres, Sandro Alves, Antonin Lamazière, Nathalie Cartier, Françoise Piguet
Publikováno v:
Pharmaceutics, Vol 16, Iss 6, p 756 (2024)
Rett syndrome (RTT) is a rare neurodevelopmental disorder caused by mutation in the X-linked gene methyl-CpG-binding protein 2 (Mecp2), a ubiquitously expressed transcriptional regulator. RTT results in mental retardation and developmental regression
Externí odkaz:
https://doaj.org/article/16c2313cb62a484b8456cc6cbf5ab1ee
Autor:
Leila Maouche, Olivier Negre, Marie Giorgi, Karine Sii-Felice, Kanit Bhukhai, Phillippe Leboulch, Anaïs Paulard, Julian D. Down, Charlotte Colomb, Beatrix Gillet-Legrand, Suparerk Borwornpinyo, Emmanuel Payen, Joëlle Cheuzeville, Helene Trebeden-Negre, Edouard de Dreuzy, Maria Denaro
Publikováno v:
Molecular Therapy
Molecular Therapy, 2018, 26 (2), pp.480-495. ⟨10.1016/j.ymthe.2017.10.015⟩
Molecular Therapy, Cell Press, 2018, 26 (2), pp.480-495. ⟨10.1016/j.ymthe.2017.10.015⟩
Molecular Therapy, 2018, 26 (2), pp.480-495. ⟨10.1016/j.ymthe.2017.10.015⟩
Molecular Therapy, Cell Press, 2018, 26 (2), pp.480-495. ⟨10.1016/j.ymthe.2017.10.015⟩
Although gene transfer to hematopoietic stem cells (HSCs) has shown therapeutic efficacy in recent trials for several individuals with inherited disorders, transduction incompleteness of the HSC population remains a hurdle to yield a cure for all pat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::163db0ada7e76223aaa4847a9f3f3e2b
https://www.hal.inserm.fr/inserm-01834780
https://www.hal.inserm.fr/inserm-01834780
Autor:
Marina Cavazzana, Yves Beuzard, Leila Maouche, Gabor Istvan Veres, Olivier Negre, Emmanuel Payen, Philippe Leboulch, Manfred Schmidt, Beatrix Gillet-Legrand, Anais Paulard, Byoung Y. Ryu, Robert H. Kutner, Annette Deichmann, Mitchell Finer, Christophe Joubert, Francis J. Pierciey, Christof von Kalle, Cynthia C. Bartholomae, Raffaele Fronza, Lauryn Christiansen, Edouard de Dreuzy, Michael Rothe, Celine Courne, Maria Denaro
Publikováno v:
Current Gene Therapy. 15:64-81
A previously published clinical trial demonstrated the benefit of autologous CD34 + cells transduced with a selfinactivating lentiviral vector (HPV569) containing an engineered β-globin gene (β A-T87Q -globin) in a subject with β thalassemia major
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ffe2176935a083d600347aa8833f6f00
https://doi.org/10.2174/1566523214666141127095336
https://doi.org/10.2174/1566523214666141127095336
Autor:
Olivier Negre, Maria Denaro, Troy Brady, Frederic D. Bushman, Charlotte Colomb, Keshet Ronen, Shannah Roth, Beatrix Gillet-Legrand, Nirav Malani, Yves Beuzard, Emmanuel Payen, Philippe Leboulch, Julian D. Down, Kathleen M. Hehir, Floriane Fusil
Publikováno v:
Molecular Therapy. 19:1273-1286
A lentiviral vector encoding β-globin flanked by insulator elements has been used to treat β-thalassemia (β-Thal) successfully in one human subject. However, a clonal expansion was observed after integration in the HMGA2 locus, raising the questio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3368b0728aea8738641efbc2024a15bc
https://doi.org/10.1038/mt.2011.20
https://doi.org/10.1038/mt.2011.20
Autor:
Olivier Negre, A Henri, Philippe Leboulch, Emmanuel Payen, Frederic D. Bushman, Floriane Fusil, Charlotte Colomb, Shoshannah L. Roth, Beatrix Gillet-Legrand, Yves Beuzard
Publikováno v:
Blood. 117:5321-5331
A challenge for gene therapy of genetic diseases is to maintain corrected cell populations in subjects undergoing transplantation in cases in which the corrected cells do not have intrinsic selective advantage over nontransduced cells. For inherited
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4936f690cae81d75e37371b6dd6da027
https://doi.org/10.1182/blood-2010-01-263582
https://doi.org/10.1182/blood-2010-01-263582
Autor:
Floriane Fusil, Stany Chrétien, Riccardo Sgarra, Beatrix Gillet-Legrand, Françoise Bernaudin, Nabil Kabbara, Robert Girot, Philippe Leboulch, Laure Caccavelli, Maria Denaro, Frédéric Galactéros, Julian D. Down, Marina Cavazzana-Calvo, Emmanuel Payen, Kathleen M. Hehir, Leila Maouche-Chretien, Bernard Gourmel, Kenneth Cornetta, Frederick D. Bushman, Axel Polack, Alain Fischer, Patrick Aubourg, Salima Hacein-Bey-Abina, Gérard Socié, Jérôme Larghero, Karen A. Westerman, Gary P. Wang, Nathalie Cartier, Eliane Gluckman, Yves Beuzard, Arthur Bank, Ronald Dorazio, Troy Brady, Geert Jan Mulder, Resy Cavallesco, Olivier Negre, Bruno Dalle, Jean Soulier
Publikováno v:
Nature
Nature, Nature Publishing Group, 2010, 467 (7313), pp.318-322. ⟨10.1038/nature09328⟩
Nature, 2010, 467 (7313), pp.318-322. ⟨10.1038/nature09328⟩
Nature, Nature Publishing Group, 2010, 467 (7313), pp.318-322. 〈10.1038/nature09328〉
Nature, Nature Publishing Group, 2010, 467 (7313), pp.318-322. ⟨10.1038/nature09328⟩
Nature, 2010, 467 (7313), pp.318-322. ⟨10.1038/nature09328⟩
Nature, Nature Publishing Group, 2010, 467 (7313), pp.318-322. 〈10.1038/nature09328〉
Blood disorders caused by abnormal β-globin — β-thalassaemia and sickle cell disease — are the most prevalent inherited disorders worldwide, with patients often remaining dependent on blood transfusions throughout their lives. So a report of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb9eef01d29156dba378353566c36122
https://hal-cea.archives-ouvertes.fr/cea-00905288
https://hal-cea.archives-ouvertes.fr/cea-00905288