Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Beatrijs M. Lodde"'
Autor:
Maria J H Boumans, Kris A. Reedquist, Eric W. Jacobson, Joelle Lufkin, Michael O'Meara, Maarten A. de Boer, Alian Bakker, Beatrijs M. Lodde, Paul P. Tak, Danielle M. Gerlag, Arno W R van Kuijk, Sarah Krausz
Publikováno v:
Arthritis and rheumatism, 64(6), 1750-1755. John Wiley and Sons Inc.
Objective To investigate the safety, tolerability, pharmacokinetics, and efficacy of apilimod mesylate, an oral interleukin-12 (IL-12)/IL-23 inhibitor, in patients with rheumatoid arthritis (RA). Methods We performed a phase IIa, randomized, double-b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51c2ff0a84e679400cfb26d3df710ecb
https://doi.org/10.1002/art.34339
https://doi.org/10.1002/art.34339
Autor:
Michael Schmidt, Fumi Mineshiba, Marc R. Kok, Changyu Zheng, Bruce J. Baum, Ana P. Cotrim, Beatrijs M. Lodde, Paul P. Tak, Jianghua Wang, Martin Kriete
Publikováno v:
Oral Diseases. 12:566-572
Objectives: The non-obese diabetic (NOD) mouse is not only a widely used model for diabetes mellitus type I, but also for the chronic autoimmune disease Sjogren's syndrome (SS), mainly affecting salivary and lacrimal glands. We studied the efficacy o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e6a41e3b9c4e312303205d69959e7d1b
https://doi.org/10.1111/j.1601-0825.2006.01241.x
https://doi.org/10.1111/j.1601-0825.2006.01241.x
Publikováno v:
Annals of the rheumatic diseases. 65(11):1406-1413
Sjogren's syndrome is an autoimmune exocrinopathy, mainly affecting the lacrimal and salivary glands, and resulting in ocular and oral dryness (keratoconjunctivitis sicca and xerostomia). The aetiology and pathogenesis are largely unknown, and only p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8db095758ce319d687143bc3179f3955
https://doi.org/10.1136/ard.2006.052761
https://doi.org/10.1136/ard.2006.052761
Kinetics of Tempol for Prevention of Xerostomia Following Head and Neck Irradiation in a Mouse Model
Autor:
Anastasia L. Sowers, Albert Kingman, Bruce J. Baum, James B. Mitchell, Ana P. Cotrim, Angelo Russo, Beatrijs M. Lodde, Joseph M. Vitolo
Publikováno v:
Clinical Cancer Research. 11:7564-7568
Purpose: Radiotherapy is commonly used to treat the majority of patients with head and neck cancers. Salivary glands in the radiation field are dramatically affected by this procedure. The purpose of this study was to examine pharmacokinetic characte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e85b69471c3f561f0de5dab4a0c31f7
https://doi.org/10.1158/1078-0432.ccr-05-0958
https://doi.org/10.1158/1078-0432.ccr-05-0958
Autor:
Jianghua Wang, Fumi Mineshiba, Michele Papa, Victor M. Rivera, Beatrijs M. Lodde, Timothy P. Clackson, Antonis Voutetakis, B J Baum
Publikováno v:
Gene Therapy. 13:187-190
Salivary glands (SGs) appear to be a useful target site for gene therapeutics. The ability to control transgene expression is essential for clinical application. Previously, in a proof-of-concept study, we have shown that the rapamycin-inducible tran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edb8e32bc26ce4e73b93b60219017073
https://doi.org/10.1038/sj.gt.3302647
https://doi.org/10.1038/sj.gt.3302647
Publikováno v:
Biochemical and Biophysical Research Communications. 319:189-192
Vasoactive intestinal peptide (VIP) is a small neuropeptide, which exerts pleiotropic functions. Based on its immunomodulatory, secretory, and possibly trophic effects, VIP is a valuable candidate molecule for the management of autoimmune disease. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5cb869a2073edc62dc9c27782c4bd7b
https://doi.org/10.1016/j.bbrc.2004.04.171
https://doi.org/10.1016/j.bbrc.2004.04.171
Autor:
Shohta Kodama, Ildiko Szalayova, Simon D. Tran, Eva Mezey, Denise L. Faustman, Beatrijs M. Lodde, Sharon Key, Saeed Khalili
Publikováno v:
Annals of the Rheumatic Diseases. 66:812-814
Background: Non-obese diabetic (NOD) mice exhibit autoimmune diabetes and Sjogren’s-like syndrome. Objective: To test whether a treatment that reverses end-stage diabetes in the NOD mouse would affect their Sjogren’s-like syndrome. Methods: NOD m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b87555e7920821d2e75215927a3950e
https://doi.org/10.1136/ard.2006.064030
https://doi.org/10.1136/ard.2006.064030
Publikováno v:
Nederlands tijdschrift voor geneeskunde. 155(30-31)
Personalised medicine has the potential to increase therapeutic effectiveness, reduce side effects and lower cost. This approach has recently taken off in oncology where different malignancies may be treated with specific drugs based on genetic bioma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ca72ce7b9bd286d8bfca88972e40735b
https://pubmed.ncbi.nlm.nih.gov/22085519
https://pubmed.ncbi.nlm.nih.gov/22085519
Autor:
Lars Klareskog, Richard Reece, Stefano Alivernini, Paul P. Tak, Douglas J. Veale, Iain B. McInnes, Ursula Fearon, Carlomaurizio Montecucco, Marleen G H van de Sande, Veronica Codullo, Paul Emery, Beatrijs M. Lodde, Lisa G. M. van Baarsen, Ioana Felea, Danielle M. Gerlag, Costantino Pitzalis, Elsa Vieira-Sousa
Publikováno v:
Annals of the rheumatic diseases, 70(3), 423-427. BMJ Publishing Group
Inflammation of synovium is one of the hallmarks of rheumatoid arthritis (RA). Analysis of synovial tissue has increased our understanding of RA pathogenesis, aided in identifying potential therapeutic targets and has been used in the response and me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d76f99f2b8ee10511c116b58426877d
http://hdl.handle.net/11562/348391
http://hdl.handle.net/11562/348391
Autor:
Rose Anne Leakan, P. P. Tak, Marc R. Kok, Beatrijs M. Lodde, Vidya Sankar, Stanley R. Pillemer
Publikováno v:
Rheumatology (Oxford, England), 45(4), 481-484. Oxford University Press
Objectives. Altered lipid levels may occur in autoimmune diseases, for example low cholesterol levels have been described in rheumatoid arthritis (RA). Serum lipid profiles in patients with Sjogren's syndrome (SS) have not been investigated. We hypot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4715101bced307c7eab6c47ab5c0eed6
https://pure.amc.nl/en/publications/serum-lipid-levels-in-sjoegrens-syndrome(bf3b011c-f6d7-4d93-a795-624a0176d8a3).html
https://pure.amc.nl/en/publications/serum-lipid-levels-in-sjoegrens-syndrome(bf3b011c-f6d7-4d93-a795-624a0176d8a3).html