Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Beatrice Y J T, Yue"'
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e92845 (2014)
Myocilin (MYOC) is a gene linked directly to juvenile- and adult-onset open angle glaucoma. Mutations including Pro370Leu (P370L) and Gln368stop (Q368X) have been identified in patients. In the present study, we investigated the processing of myocili
Externí odkaz:
https://doaj.org/article/b3cef52033db498fa78bae00798ed59f
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e44902 (2012)
Myocilin is a gene linked to the most prevalent form of glaucoma, a major blinding disease. The trabecular meshwork (TM), a specialized eye tissue, is believed to be involved, at least in part, in the development of glaucoma. The Pro³⁷⁰ to Leu (
Externí odkaz:
https://doaj.org/article/cb515fb7cad5408893a44abfb214b322
Publikováno v:
PLoS ONE, Vol 7, Iss 10, p e47307 (2012)
Myocilin is a gene linked directly to juvenile- and adult-onset open angle glaucoma. Mutations including Gln368stop (Q368X) and Pro370Leu (P370L) have been identified in patients. The exact role of myocilin and its functional association with glaucom
Externí odkaz:
https://doaj.org/article/7a8b8beee4ce42a38798ab349e51a67f
Autor:
BumChan Park, Hongyu Ying, Xiang Shen, Jeong-Seok Park, Ye Qiu, Rajalekshmy Shyam, Beatrice Y J T Yue
Publikováno v:
PLoS ONE, Vol 5, Iss 7, p e11547 (2010)
Glaucoma is a major blinding disease characterized by progressive loss of retinal ganglion cells (RGCs) and axons. Optineurin is one of the candidate genes identified so far. A mutation of Glu(50) to Lys (E50K) has been reported to be associated with
Externí odkaz:
https://doaj.org/article/5a96b97f7ea44395bab6b748ca7b6a1e
Publikováno v:
PLoS ONE, Vol 5, Iss 2, p e9168 (2010)
Glaucoma is a major blinding disease. The most common form of this disease, primary open angle glaucoma (POAG), is genetically heterogeneous. One of the candidate genes, optineurin, is linked principally to normal tension glaucoma, a subtype of POAG.
Externí odkaz:
https://doaj.org/article/570e830c25ba46afb42129bf0d698a5c
Autor:
Algis, Grybauskas, Tomoyo, Koga, Paulius V, Kuprys, Michael, Nolan, Ryan, McCarty, Loyal, Walker, Kelsey A, Green, William M, Norkett, Beatrice Y J T, Yue, Paul A, Knepper
Publikováno v:
Molecular Vision
Purpose The aqueous humor nourishes the avascular tissues of the anterior segment, and the trabecular meshwork (TM) plays a role in the efflux of endogenous substances and xenobiotics from the aqueous humor. ATP (ATP)-binding cassette (ABC) transport
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9a108be3f2bb7ea249c3af25fd825670
https://pubmed.ncbi.nlm.nih.gov/25802484
https://pubmed.ncbi.nlm.nih.gov/25802484
Publikováno v:
Molecular Vision
Purpose The aim of this study was to examine the expression of genes related to the Wnt signaling pathway, such as β-catenin (CTNNB1) and secreted frizzled-related protein-1 (sFRP1), in human trabecular meshwork (TM) cells. In addition, the effect o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9a129b8f1c5bb106869de4c32432ee13
https://pubmed.ncbi.nlm.nih.gov/20111673
https://pubmed.ncbi.nlm.nih.gov/20111673
Publikováno v:
Molecular vision. 13
To examine the temporal and spatial expression of Sp1 and Krüppel-like factor 6 (KLF6) in the cornea in fetal and adult human eyes.Eyes from human fetus (F) of 7, 9, 10, 11, 13, and 27 weeks (w) of gestation, as well as corneas from 11 and 56-day (d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1c63d1c00938d1bf6d6bf65e947f1725
https://pubmed.ncbi.nlm.nih.gov/17893646
https://pubmed.ncbi.nlm.nih.gov/17893646
Publikováno v:
The American journal of pathology. 169(6)
Optineurin (OPTN) has recently been linked to glaucoma, a major cause of blindness worldwide. Mutations in OPTN such as Glu50→Lys (E50K) have been reported in patients, particularly those with normal pressure glaucoma. Here, we show that the endoge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e664809b4c691becb051cbbb3aa03073
https://pubmed.ncbi.nlm.nih.gov/17148662
https://pubmed.ncbi.nlm.nih.gov/17148662
Autor:
Hiroshi, Nakamura, Shahid S, Siddiqui, Xiang, Shen, Asrar B, Malik, Jose S, Pulido, Nalin M, Kumar, Beatrice Y J T, Yue
Publikováno v:
Molecular vision. 10
Transforming growth factor-beta(TGF-beta) is an important mediator of wound healing responses. In the eye, TGF-beta activity has been implicated in causing corneal haze after laser surgery and subconjunctival scarring following glaucoma surgery. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8c2728b7bec36a0b21a730a8aab944bc
https://pubmed.ncbi.nlm.nih.gov/15475878
https://pubmed.ncbi.nlm.nih.gov/15475878