Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Beatrice Rendenbach-Mueller"'
Autor:
Hana Florian, Deli Wang, Steven E Arnold, Mercè Boada, Qi Guo, Ziyi Jin, Hui Zheng, Nahome Fisseha, Hari Varun Kalluri, Beatrice Rendenbach-Mueller, Kumar Budur, Michael Gold
Publikováno v:
Brain. 146:2275-2284
Tau accumulation in patients with Alzheimer’s disease tracks closely with cognitive decline and plays a role in the later stages of disease progression. This phase 2 study evaluated the safety and efficacy of tilavonemab, an anti-tau monoclonal ant
Autor:
Wassilios G. Meissner, Roberto Eleopra, Taku Hatano, Francisco Grandas, Joseph F. Quinn, Justyna Sarna, Hui Zheng, Osamu Onodera, John T. Slevin, Theresa A. Zesiewicz, Anwar Ahmed, Erika Driver-Dunckley, Tao Xie, Hidek Mochizuki, Deborah A. Hall, John O`Sullivan, Peter A. Ljubenkov, Carlo Colosimo, Tomoko Oeda, Luc Defebvre, Diana R. Kerwin, Hana Florian, Deli Wang, Hoi-Kei Lon, David S. Geldmacher, Nahome Fisseha, Jennifer Hui, Elizabeth Peckham, Noriko Nishikawa, Jean-Christophe Corvol, Günter U. Höglinger, Jared Brosch, Fabienne Ory-Magne, Alberto Albanese, Kumar Budur, Yvette Bordelon, Zbigniew K. Wszolek, Stefano Ruggieri, Akio Kikuchi, James H. Bower, Kelly Bertram, Antonio Daniele, Daryl Wile, Ikuko Aiba, Rajeev Kumar, Lawrence S. Honig, Daniel Claassen, Victor S.C. Fung, Renato P. Munhoz, Beatrice Rendenbach-Mueller, Michael Gold, Ziyi Jin, Albert C. Ludolph, Nuno Mendonca, Ronald B. Postuma, John C. Morgan, Alexandre Eusebio, Aldo Quattrone, Antoine Duquette, Pablo Mir Rivera, Irene Litvan, Thomas E. Kimber, Michele Tagliati, Paola Cudia, Stefan Lorenzl, Takashi Kimura, Zoltan Mari, Hideki Oizumi, Nikolaus R. McFarland, Davis C. Ryman, Lawrence I. Golbe, Paul E Schulz
Publikováno v:
The lancet / Neurology 20(3), 182-192 (2021). doi:10.1016/S1474-4422(20)30489-0
Summary Background Progressive supranuclear palsy is a neurodegenerative disorder associated with tau protein aggregation. Tilavonemab (ABBV-8E12) is a monoclonal antibody that binds to the N-terminus of human tau. We assessed the safety and efficacy
Autor:
Marjoleen Nijsen, Katja Jantos, Helmut Mack, Wilfried Hornberger, Achim Moeller, Andreas Kling, Gisela Backfisch, Yanbin Lao, Beatrice Rendenbach-Mueller
Publikováno v:
ACS Medicinal Chemistry Letters. 9:221-226
[Image: see text] Dysregulation of calpains 1 and 2 has been implicated in a variety of pathological disorders including ischemia/reperfusion injuries, kidney diseases, cataract formation, and neurodegenerative diseases such as Alzheimer’s disease
Autor:
Eric C. Strain, Nassima Ait-Daoud, Charles Scott, Beatrice Rendenbach-Mueller, George F. Koob, Laurie Sickles-Colaneri, Daniel E. Falk, Kelly E. Dunn, Elizabeth M. Mahoney, Raye Z. Litten, Joanne B. Fertig, Katherine A. Tracy, Kyle M. Kampman, David A. Katz, Domenic A. Ciraulo, Janet Ransom, Bankole A. Johnson, Megan L. Ryan
Publikováno v:
Neuropsychopharmacology. 42:1012-1023
Alcohol use disorder has been linked to dysregulation of the brain stress systems, producing a negative emotional state leading to chronic relapsing behavior. Vasopressin receptors appear to have a regulatory role in stress, anxiety, and alcohol. Thi
Autor:
Kumar Budur, Hana Florian, Nuno Mendonca, Beatrice Rendenbach-Mueller, Sheng Feng, Holly Soares, Michael Gold, Hoi-Kei Lon
Publikováno v:
Alzheimer's & Dementia. 14
Autor:
Holly Soares, Beatrice Rendenbach-Mueller, Hana Florian, Deli Wang, Dave M. Holtzman, Nuno Mendonca, Randall J. Bateman, Kumar Budur, Weining Z. Robieson, Joel B. Braunstein
Publikováno v:
Alzheimer's & Dementia. 14
Autor:
Beatrice Rendenbach-Mueller, Sandra L. Goss, Ahmed A. Othman, Hoi-Kei Lon, Charles Locke, Nuno Mendonca, Ziyi Jin
Publikováno v:
Clinical pharmacology in drug development. 8(3)
Alicapistat is an orally active selective inhibitor of calpain 1 and 2 whose overactivation has been linked to Alzheimer disease (AD). Three studies were conducted in healthy subjects (18-55 years), 1 in healthy elderly subjects (≥65 years), and 1
Autor:
Erik D. Roberson, Ilana Fogelman, Irene Litvan, Joel B. Braunstein, Helen Hu, David M. Holtzman, Randall J. Bateman, Davis C. Ryman, Nuno Mendonca, Hana Florian, Tim West, Beatrice Rendenbach-Mueller, Sandra L. Goss, Adam L. Boxer, Philip B. Verghese, Deli Wang, Kumar Budur, Laura M. Gault, Diana R. Kerwin, Yvette Bordelon
Publikováno v:
Alzheimer's & Dementia. 13
Autor:
Beatrice Rendenbach-Mueller, Mario David Saltarelli, Sandra L. Goss, Yaqin Wang, Walid M. Abi-Saab, Laura Redden, Armen Goenjian, David A. Katz, Weining Z. Robieson, Nicholas Greco
Publikováno v:
Journal of Clinical Psychopharmacology. 31:221-225
There is substantial preclinical and clinical evidence to suggest a potential role for the dopamine D 3 receptor in the treatment of schizophrenia. ABT-925 is a selective dopamine D 3 receptor antagonist with an approximately 100-fold higher in vitro
Autor:
Adrian D. Hobson, Reinhold Mueller, Anton Bespalov, Mario Mezler, Christopher M. Harris, Hans Schoemaker, Elizabeth Louise van der Kam, Sean Turner, Jeroen van Bergeijk, Beatrice Rendenbach-Mueller
Publikováno v:
Alzheimer's & Dementia. 10