Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Beatrice Paul-Roc"'
Autor:
Anne E.G. Lenferink, Paul C. McDonald, Christiane Cantin, Suzanne Grothé, Mylene Gosselin, Jason Baardsnes, Myriam Banville, Paul Lachance, Alma Robert, Yuneivy Cepero-Donates, Stevo Radinovic, Patrick Salois, Marie Parat, Hafida Oamari, Annie Dulude, Mehul Patel, Martin Lafrance, Andrea Acel, Nathalie Bousquet-Gagnon, Denis L’Abbé, Alex Pelletier, Félix Malenfant, Maria Jaramillo, Maureen O’Connor-Mccourt, Cunle Wu, Yves Durocher, Mélanie Duchesne, Christine Gadoury, Anne Marcil, Yves Fortin, Beatrice Paul-Roc, Maurizio Acchione, Shawn C. Chafe, Oksana Nemirovsky, Joseph Lau, Francois Bénard, Shoukat Dedhar
Publikováno v:
mAbs, Vol 13, Iss 1 (2021)
The architectural complexity and heterogeneity of the tumor microenvironment (TME) remains a substantial obstacle in the successful treatment of cancer. Hypoxia, caused by insufficient oxygen supply, and acidosis, resulting from the expulsion of acid
Externí odkaz:
https://doaj.org/article/a78bd5c3c72d4143937f4cd8eec87eef
Autor:
Paul C. McDonald, Christiane Cantin, Hafida Oamari, Alma Robert, Alex Pelletier, Anne Marcil, Myriam Banville, Suzanne Grothe, Stevo Radinovic, Cunle Wu, Mélanie Duchesne, Francois Benard, Nathalie Bousquet-Gagnon, Andrea Acel, Marie Parat, Maurizio Acchione, Annie Dulude, Shoukat Dedhar, Joseph Lau, Maria L. Jaramillo, Maureen D. O'Connor-McCourt, Yves Durocher, Christine Gadoury, Yves Fortin, Beatrice Paul-Roc, Yuneivy Cepero-Donates, Denis L'Abbé, Jason Baardsnes, Félix Malenfant, Anne E.G. Lenferink, Mylene Gosselin, Mehul Patel, Patrick Salois, Martin Lafrance, Oksana Nemirovsky, Paul Lachance, Shawn C. Chafe
Publikováno v:
mAbs
article-version (VoR) Version of Record
article-version (VoR) Version of Record
The architectural complexity and heterogeneity of the tumor microenvironment (TME) remains a substantial obstacle in the successful treatment of cancer. Hypoxia, caused by insufficient oxygen supply, and acidosis, resulting from the expulsion of acid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::490ba9b15ff09e7944d25cf4f097acfc
https://doi.org/10.1080/19420862.2021.1999194
https://doi.org/10.1080/19420862.2021.1999194
Autor:
Mehdi Arbabi Ghahroudi, Joey G. Sheff, Traian Sulea, Mylene Gosselin, Anne E.G. Lenferink, John C. Zwaagstra, Nazanin Rohani Larijani, Beatrice Paul Roc
Publikováno v:
Cancer Research. 80:PO-049
The tumor acidic microenvironment is a fundamental characteristic of solid tumors which distinguishes the tumor from adjacent normal tissues. This unique tumor microenvironment (TME) feature directly contributes to various aspect of tumor progression
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::28fc2b1490f77fe5fcf19d0311a950d0
https://doi.org/10.1158/1538-7445.tumhet2020-po-049
https://doi.org/10.1158/1538-7445.tumhet2020-po-049
Autor:
Eric Grazzini, Jason Baardsnes, Alina Burlacu, Sylvie Perret, Yves Durocher, Martin Loignon, Matthew Stuible, Denis Brochu, Beatrice Paul-Roc
Publikováno v:
Journal of biotechnology. 281
For pre-clinical evaluation of biotherapeutic candidates, protein production by transient gene expression (TGE) in Chinese Hamster Ovary (CHO) cells offers important advantages, including the capability of rapidly and cost-effectively generating reco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b42b7261e196f3a44b8d2289f098740
https://pubmed.ncbi.nlm.nih.gov/29886030
https://pubmed.ncbi.nlm.nih.gov/29886030
Autor:
Maria L. Jaramillo, Myriam Banville, Lucie Bourget, Maureen D. O'Connor-McCourt, Beatrice Paul-Roc, Catherine Collins
Publikováno v:
Cancer Biology & Therapy. 7:557-568
It has been demonstrated that A549 non-small cell lung cancer (NSCLC) cells are sensitive to epidermal growth factor receptor (EGFR) inhibitors in in vivo xenograft animal models, but are relatively resistant in conventional in vitro monolayer growth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c4fb48d1ab586482caa47756084cd2f
https://doi.org/10.4161/cbt.7.4.5533
https://doi.org/10.4161/cbt.7.4.5533
Autor:
Denis L'Abbé, Christiane Cantin, Roseanne Tom, Suzanne Grothe, John C. Zwaagstra, Brian Cass, Jason Baardsnes, Maureen D. O'Connor-McCourt, Louis-Philippe Richer, Anne E.G. Lenferink, Beatrice Paul-Roc, Traian Sulea, Sazzad Hossain, Yves Durocher, Cathy Collins
Deregulation of TGF-β superfamily signaling is a causative factor in many diseases. Here we describe a protein engineering strategy for the generation of single-chain bivalent receptor traps for TGF-β superfamily ligands. Traps were assembled using
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2d9fec00b0c2ea529ecdb11e4169ae7
https://nrc-publications.canada.ca/eng/view/object/?id=59aa1f63-b3d4-469b-945c-03ed9d5b9f9a
https://nrc-publications.canada.ca/eng/view/object/?id=59aa1f63-b3d4-469b-945c-03ed9d5b9f9a
Autor:
Ping Xu, Maureen D. O'Connor-McCourt, Feng Ni, Dmitri Tolkatchev, Rana Filfil, Anne E.G. Lenferink, Beatrice Paul-Roc, Umar Iqbal, Christiane Cantin, Anna Vinogradova
Several reports have shown that secreted clusterin (sCLU) plays multiple roles in tumor development and metastasis. Here, we report on a 12-mer sCLU binding peptide (designated P3378) that was identified by screening a phage-display peptide library a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::626dca1a259e8e0d4bf82784b6608a87
https://nrc-publications.canada.ca/eng/view/object/?id=5c47a73a-9c74-48be-8367-c2697ed9b395
https://nrc-publications.canada.ca/eng/view/object/?id=5c47a73a-9c74-48be-8367-c2697ed9b395
Autor:
Beatrice Paul-Roc, Maria L. Jaramillo, Ilia Alexandre Tikhomirov, Jason Baardsnes, Suzanne Grothe, Myriam Banville, Maureen O'Connor, Sean El Thompson
Introduction: Glioblastomas frequently overexpress a variant form of EGFR, called variant III (EGFRvIII), which has an in-frame deletion of an 801-bp sequence in the extracellular domain. EGFRvIII does not bind EGF ligand but exhibits constitutive ki
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9fbdf1ac67d85a41d4ab134ba5b7937
https://nrc-publications.canada.ca/eng/view/object/?id=43443b1e-1317-4128-add5-1985a326a41b
https://nrc-publications.canada.ca/eng/view/object/?id=43443b1e-1317-4128-add5-1985a326a41b
Autor:
Edwin Wang, Anne Marcil, Christiane Cantin, Myriam Banville, Mark R. Wilson, Yves Durocher, Beatrice Paul-Roc, Anne E.G. Lenferink, Maureen D. O'Connor-McCourt, André Nantel
Publikováno v:
Oncogene. 29(6)
Transforming growth factor (TGF)-beta plays a dual role in tumorigenesis, switching from acting as a growth inhibitory tumor suppressor early in the process, to a tumor promoter in late-stage disease. Since TGF-beta's prometastatic role may be linked
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::450312ba7b9e7cd8a5fd56a0d9e0e518
https://pubmed.ncbi.nlm.nih.gov/19935703
https://pubmed.ncbi.nlm.nih.gov/19935703
Autor:
Abedelnasser Abulrob, Maureen O’connor Mccourt, Zully Leon, Maria L. Jaramillo, Beatrice Paul-Roc, Suzanne Grothe
The anti-receptor antibody, 225 mAb, is known to block binding of ligand to the epidermal growth factor receptor (EGFR). However, the effect of this neutralizing antibody on EGFR endocytosis, trafficking and degradation remains unclear. Here, we demo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16c327a5c7c9bed9973197aedb4fd057
https://doi.org/10.1016/j.yexcr.2006.05.008
https://doi.org/10.1016/j.yexcr.2006.05.008