Phenotyping patients with ischaemic heart disease at risk of developing heart failure: an analysis of the HOMAGE trial

Autor: Diogo Santos‐Ferreira, Sílvia O. Diaz, João Pedro Ferreira, Nicolas Girerd, Pierpaolo Pellicori, Beatrice Mariottoni, Franco Cosmi, Mark Hazebroek, Job A.J. Verdonschot, Joe Cuthbert, Johannes Petutschnigg, Stephane Heymans, Jan A. Staessen, Burkert Pieske, Frank Edelmann, Andrew L. Clark, Patrick Rossignol, Ricardo Fontes‐Carvalho, John G.F. Cleland, Faiez Zannad

Publikováno v: ESC Heart Failure, Vol 11, Iss 1, Pp 209-218 (2024)

Abstract Aims We aim to characterize the clinical and proteomic profiles of patients at risk of developing heart failure (HF), with and without coronary artery disease (CAD) or prior myocardial infarction (MI). Methods and results HOMAGE evaluated th

Externí odkaz: https://doaj.org/article/b932ab1074da40f1bcc43e8db1ce3d81

Proteomic mechanistic profile of patients with diabetes at risk of developing heart failure: insights from the HOMAGE trial

Autor: Job A. J. Verdonschot, João Pedro Ferreira, Pierpaolo Pellicori, Hans-Peter Brunner-La Rocca, Andrew L. Clark, Franco Cosmi, Joe Cuthbert, Nicolas Girerd, Beatrice Mariottoni, Johannes Petutschnigg, Patrick Rossignol, John G. F. Cleland, Faiez Zannad, Stephane R. B. Heymans, HOMAGE “Heart Omics in AGEing” consortium

Publikováno v: Cardiovascular Diabetology, Vol 20, Iss 1, Pp 1-10 (2021)

Abstract Background Patients with diabetes mellitus (DM) are at increased risk of developing heart failure (HF). The “Heart OMics in AGEing” (HOMAGE) trial suggested that spironolactone had beneficial effect on fibrosis and cardiac remodelling in

Externí odkaz: https://doaj.org/article/e14de118673048909bafad7206cc7788

Spironolactone effect on cardiac structure and function of patients with heart failure and preserved ejection fraction: a pooled analysis of three randomized trials

Autor: João Pedro Ferreira, John G. Cleland, Nicolas Girerd, Erwan Bozec, Patrick Rossignol, Pierpaolo Pellicori, Franco Cosmi, Beatrice Mariottoni, Scott D. Solomon, Bertram Pitt, Marc A. Pfeffer, Amil M. Shah, Johannes Petutschnigg, Burkert Pieske, Frank Edelmann, Faiez Zannad

Publikováno v: European Journal of Heart Failure
European Journal of Heart Failure, 2022, 25, pp.108-113. ⟨10.1002/ejhf.2726⟩

International audience; Aims: Spironolactone is currently used in a large proportion of patients with heart failure and preserved ejection fraction (HFpEF), yet its effect on cardiac structure and function in a large population has not been well esta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27ecee236ed01a4b1673da02d967e740
https://doi.org/10.1002/ejhf.2726

Urinary Proteomic Signature of Mineralocorticoid Receptor Antagonism by Spironolactone: Evidence from the Randomized-Controlled HOMAGE and PRIORITY Trials

Autor: Yu-Ling Yu, Viktor Rotbain-Curovic, Justyna Siwy, De-Wei An, Nete Tofte, Arantxa González, Morton K. Lindhardt, Tine W Hansen, Agnieszka Latosinska, João Pedro Ferreira, Pierpaolo Pellicori, Susana Ravassa, Beatrice Mariottoni, Job A.J. Verdonschot, Fozia Z. Ahmed, Johannes Petutschnigg, Patrick Rossignol, Stephane Heymans, Joe Cuthbert, Nicolas Girerd, Andrew L. Clark, Peter Verhamme, Tim S. Nawrot, Stefan Janssens, John G.F. Cleland, Faiez Zannad, Peter Rossing, Javier Díez, Harald Mischak, Jan A. Staessen

BACKGROUNDMineralocorticoid receptor (MR) activation induces fibrosis. Urinary proteomic profiling (UPP) detects thousands of sequenced peptides, mainly derived from collagen. No previous study applied UPP to generate insights in the antifibrotic act

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::82785fa0d3f3cacbbb7236eec611de1a
https://doi.org/10.1101/2023.04.05.23288107

The Effect of Spironolactone in Patients With Obesity at Risk for Heart Failure: Proteomic Insights from the HOMAGE Trial

Autor: Job A.J. Verdonschot, JoÃo Pedro Ferreira, Anne Pizard, Pierpaolo Pellicori, Hans-Peter Brunner La Rocca, Andrew L. Clark, Franco Cosmi, Joe Cuthbert, Nicolas Girerd, Olivia J. Waring, Michiel H.T.M. Henkens, Beatrice Mariottoni, Johannes Petutschnigg, Patrick Rossignol, Mark R. Hazebroek, John G.F. Cleland, Faiez Zannad, Stephane R.B. Heymans

Publikováno v: Journal of Cardiac Failure
Journal of Cardiac Failure, Elsevier, 2021, S1071-9164 (21), pp.00501-7. ⟨10.1016/j.cardfail.2021.12.005⟩
Journal of Cardiac Failure, 28(5), 778-786. Churchill Livingstone Inc Medical Publishers
Journal of Cardiac Failure, Elsevier, 2021, ⟨10.1016/j.cardfail.2021.12.005⟩

BACKGROUND: Adipose tissue influences the expression and degradation of circulating biomarkers. We aimed to identify the biomarker profile and biological meaning of biomarkers associated with obesity to assess the effect of spironolactone on the circ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae9c36c7a43563826b4bca6e70a19deb
https://lirias.kuleuven.be/handle/20.500.12942/715518