Infection-induced extracellular vesicles evoke neuronal transcriptional and epigenetic changes

Autor: Ellen Tedford, Norhidayah Binti Badya, Conor Laing, Nozomi Asaoka, Shuji Kaneko, Beatrice Maria Filippi, Glenn Alan McConkey

Publikováno v: Scientific Reports, Vol 13, Iss 1, Pp 1-16 (2023)

Abstract Infection with the protozoan Toxoplasma gondii induces changes in neurotransmission, neuroinflammation, and behavior, yet it remains elusive how these changes come about. In this study we investigated how norepinephrine levels are altered by

Externí odkaz: https://doaj.org/article/6477603b1f3c44a6ba30dd54c220a8dc

ATP and MO25alpha regulate the conformational state of the STRADalpha pseudokinase and activation of the LKB1 tumour suppressor.

Autor: Elton Zeqiraj, Beatrice Maria Filippi, Simon Goldie, Iva Navratilova, Jérôme Boudeau, Maria Deak, Dario R Alessi, Daan M F van Aalten

Publikováno v: PLoS Biology, Vol 7, Iss 6, p e1000126 (2009)

Pseudokinases lack essential residues for kinase activity, yet are emerging as important regulators of signal transduction networks. The pseudokinase STRAD activates the LKB1 tumour suppressor by forming a heterotrimeric complex with LKB1 and the sca

Externí odkaz: https://doaj.org/article/87243bf4692f4c489aefd29c82f67659

A novel pathway of cell growth regulation mediated by a PLA2α‐derived phosphoinositide metabolite

Autor: Stefania Mariggio, Jordi Sebastià, Beatrice Maria Filippi, Cristiano Iurisci, Cinzia Volonté, Susanna Amadio, Valentina De Falco, Massimo Santoro, Daniela Corda

Publikováno v: The FASEB journal (Online) 20 (2006): 2567–2569. doi:10.1096/fj.05-5397fje
info:cnr-pdr/source/autori:Mariggio S., Sebastia J., Filippi B.M., Iurisci C., Volontè C., Amadio S., De Falco V., Santoro M., Corda D./titolo:A novel pathway of cell growth regulation mediated by a PLA2{alpha}-derived phosphoinositide metabolite./doi:10.1096%2Ffj.05-5397fje/rivista:The FASEB journal (Online)/anno:2006/pagina_da:2567/pagina_a:2569/intervallo_pagine:2567–2569/volume:20
The FASEB journal 20 (2006): 2567–2569. doi:10.1096/fj.05-5397fje
info:cnr-pdr/source/autori:Mariggiò S.; Sebastià J.; Filippi B.M.; Iurisci C.; Volonté C.; Amadio S.; De Falco V.; Santoro M.; Corda D./titolo:A novel pathway of cell growth regulation mediated by a PLA2alpha-derived phosphoinositide metabolite/doi:10.1096%2Ffj.05-5397fje/rivista:The FASEB journal/anno:2006/pagina_da:2567/pagina_a:2569/intervallo_pagine:2567–2569/volume:20

The phosphoinositides have well-defined roles in the control of cellular functions, including cytoskeleton dynamics, membrane trafficking, and cell signaling. However, the interplay among the phosphoinositides and their diffusible derivatives that or

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cebe9b9d0bf973424eaa93f69ac909d1
https://doi.org/10.1096/fj.05-5397fje