Výsledky vyhledávání - "Beatrice Mandon-Pepin"

Akademický článek

Spatio-Temporal Gene Expression Profiling during In Vivo Early Ovarian Folliculogenesis: Integrated Transcriptomic Study and Molecular Signature of Early Follicular Growth.

Autor: Agnes Bonnet, Bertrand Servin, Philippe Mulsant, Beatrice Mandon-Pepin

Publikováno v: PLoS ONE, Vol 10, Iss 11, p e0141482 (2015)

The successful achievement of early ovarian folliculogenesis is important for fertility and reproductive life span. This complex biological process requires the appropriate expression of numerous genes at each developmental stage, in each follicular

Externí odkaz: https://doaj.org/article/248e4b96dad447d5992dc5efd9861471

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Fetal estrogens are not involved in sex determination but critical for early ovarian differentiation in rabbits

Autor: Eloïse Airaud, Aurélie Dewaele, Laurent Boulanger, Nathalie Daniel-Carlier, Frank Giton, Beatrice Mandon-Pepin, Maëlle Pannetier, Geneviève Jolivet, Cloé Pierson, Eric Pailhoux, Erwana Harscoët, Nathalie Daniel

Publikováno v: Endocrinology
Endocrinology, Endocrine Society, 2021, ⟨10.1210/endocr/bqab210⟩
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Endocrinology, Endocrine Society, 2022, 163 (1), ⟨10.1210/endocr/bqab210⟩

AROMATASE, encoded by the CYP19A1 gene, is the cytochrome enzyme responsible for the synthesis of estrogens in vertebrates. In most mammals a peak of expression of the CYP19A1 gene occurs in the fetal XX gonad when sexual differentiation starts up. T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1760ab13fbb6a1ccd6d064555bd50a2e
https://hal.archives-ouvertes.fr/hal-03370216

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Structural and Functional Characterization of a Testicular Long Non-coding RNA (4930463O16Rik) Identified in the Meiotic Arrest of the Mouse Topaz1–/– Testes

Autor: Eli Sellem, Elodie Poumerol, Luc Jouneau, Bruno Passet, Eric Pailhoux, Beatrice Mandon-Pepin, Johan Castille, Manon Chadourne

Publikováno v: Frontiers in Cell and Developmental Biology
Frontiers in Cell and Developmental Biology, Frontiers media, 2021, 9, ⟨10.3389/fcell.2021.700290⟩
Frontiers in Cell and Developmental Biology, Vol 9 (2021)

Spermatogenesis involves coordinated processes, including meiosis, to produce functional gametes. We previously reportedTopaz1as a germ cell-specific gene highly conserved in vertebrates.Topaz1knockout males are sterile with testes that lack haploid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d2b003def38bb667238fb11da42becc
https://hal.inrae.fr/hal-03281905

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Topaz1, an essential gene for murine spermatogenesis, down-regulates the expression of numerous testis-specific long non-coding RNAs

Autor: Eli Sellem, Bruno Passet, Manon Chadourne, Elodie Poumerol, Johan Castille, Eric Pailhoux, Beatrice Mandon-Pepin, Luc Jouneau

Spermatogenesis comprises a coordinated process, including meiosis, to produce fertile male gametes. Previous study reported that Topaz1 is a germ cell specific gene highly conserved in vertebrates. Topaz1 knockout male mice are sterile. The mutant t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c7a3da79064f93b2c229ec20fea0902b
https://doi.org/10.1101/2021.03.09.434544

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Will whole-genome sequencing become the first-line genetic analysis for male infertility in the near future?

Autor: François Vialard, Valérie Serazin, François Marcelli, Beatrice Mandon-Pepin, Nelly Swierkowsky-Blanchard, Anne-Laure Barbotin, Farah Ghieh, Clara Leroy

Publikováno v: Basic and clinical andrology
Basic and clinical andrology, BioMed Central, 2021, 31 (1), ⟨10.1186/s12610-021-00138-4⟩
Basic and Clinical Andrology, Vol 31, Iss 1, Pp 1-5 (2021)
Basic and Clinical Andrology

International audience; Whereas the initially strategy for the genetic analysis of male infertility was based on a candidate gene approach, the development of next-generation sequencing technologies (such as whole-exome sequencing (WES)) provides an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25ac474fbf34a10e4cc81e18215411ed
https://hal.inrae.fr/hal-03327919

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Human testis-expressed (TEX) genes: a review focused on spermatogenesis and male fertility

Autor: Beatrice Mandon-Pepin, Emeline Hermel, Hela Bellil, François Vialard, Farah Ghieh

Publikováno v: Basic and clinical andrology
Basic and clinical andrology, BioMed Central, 2021, 31 (1), ⟨10.1186/s12610-021-00127-7⟩
Basic and Clinical Andrology, Vol 31, Iss 1, Pp 1-15 (2021)
Basic and Clinical Andrology

International audience; Abstract Spermatogenesis is a complex process regulated by a multitude of genes. The identification and characterization of male-germ-cell-specific genes is crucial to understanding the mechanisms through which the cells devel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c9485207908404bd6c72b52fd45389d
https://hal.archives-ouvertes.fr/hal-03216070

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Azoospermia and reciprocal translocations: should whole-exome sequencing be recommended?

Autor: François Vialard, Anne-Laure Barbotin, Valérie Serazin, François Marcelli, Beatrice Mandon-Pepin, Clara Leroy, Henri-Jean Garchon, Julie Prasivoravong, Joanne Fortemps, Farah Ghieh, Sophie Ferlicot

Publikováno v: Basic and clinical andrology
Basic and clinical andrology, BioMed Central, 2021, 31 (1), ⟨10.1186/s12610-021-00145-5⟩
Basic and clinical andrology, BioMed Central, 2021, 31 (27), ⟨10.1186/s12610-021-00145-5⟩
Basic and Clinical Andrology
Basic and Clinical Andrology, Vol 31, Iss 1, Pp 1-8 (2021)

Background Although chromosome rearrangements are responsible for spermatogenesis failure, their impact depends greatly on the chromosomes involved. At present, karyotyping and Y chromosome microdeletion screening are the first-line genetic tests for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6885238ba8a0de6ec32f05e2a32aa661
https://hal.inrae.fr/hal-03455754

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Prenatal cannabinoid exposure alters the ovarian reserve in adult offspring of rats

Autor: Hubert Lepidi, Anne-Laure Pelissier-Alicot, Beatrice Mandon-Pepin, Blandine Courbiere, Magalie Barbier, Elodie Poumerol, Pierre Castel, Olivier J. Manzoni, Virginie Tassistro

Publikováno v: Archives of Toxicology
Archives of Toxicology, Springer Verlag, 2020, 94 (12), pp.4131-4141. ⟨10.1007/s00204-020-02877-1⟩
Archives of Toxicology, 2020, 94 (12), pp.4131-4141. ⟨10.1007/s00204-020-02877-1⟩

International audience; In animals, research in the past two decades has demonstrated the strong involvement of the endocannabinoid system (ECS) in numerous steps of the reproductive process, including ovarian physiology. Reproductive lifespan is clo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cff1944cc47fe346b6b454c42f913b78
https://pubmed.ncbi.nlm.nih.gov/32833042

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Genetic defects in human azoospermia

Autor: Farah Ghieh, François Vialard, Beatrice Mandon-Pepin, Valérie Mitchell

Publikováno v: Basic and clinical andrology
Basic and clinical andrology, 2019, 29 (1), pp.4. ⟨10.1186/s12610-019-0086-6⟩
Basic and Clinical Andrology 4 (29), 16p. (2019)
Basic and clinical andrology, BioMed Central, 2019, 29 (1), pp.4. ⟨10.1186/s12610-019-0086-6⟩
Basic and Clinical Andrology
Basic and Clinical Andrology, Vol 29, Iss 1, Pp 1-16 (2019)

Résumé Comme pour beaucoup de maladies humaines, les analyses génétiques en cas d’azoospermie étaient initialement limitées à la réalisation d’un caryotype, conduisant au diagnostic de réarrangements chromosomiques comme pour le syndrome

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8209ad1ee287ca3ae4b9df7935ae3374
https://hal.science/hal-02315267/document

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