Výsledky vyhledávání - "Beatrice Macino"

Autor: Giuseppe Basso, Fabiola Bernardi, Carlo Riccardo Rossi, Paola Zanovello, Valeria Tosello, Beatrice Macino, Susanna Mandruzzato, Cristina Montesco, Elisabetta Rossi, Vanna Chiarion-Sileni

Publikováno v: Scopus-Elsevier
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Europe PubMed Central

It is widely accepted that the repertoire of Melan-A-specific T cells naturally selected in melanoma patients is diverse and mostly nonoverlapping among different individuals. To date, however, no studies have addressed the TCR profile in different t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcb02ae4ba8b836139b08803e048b53c
https://doi.org/10.4049/jimmunol.169.7.4017

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MAGE,BAGE, andGAGE gene expression in patients with esophageal squamous cell carcinoma and adenocarcinoma of the gastric cardia

Autor: Beatrice Macino, Susanna Mandruzzato, Stefano Merigliano, Paola Zanovello, Annalisa Zambon, Alberto Ruol, Anna Parenti, Giovanni Zaninotto, Piero Dalerba

Publikováno v: Cancer. 91:1882-1888

BACKGROUND. The MAGE, BAGE, and GAGE gene families code for distinct, tumor specific antigens that are recognized by cytotoxic T lymphocytes in the context of HLA molecules. The purpose of this study was to analyze MAGE, BAGE, and GAGE gene expressio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::200bcfb2bad0165d177a6247e4a0c77f
https://doi.org/10.1002/1097-0142(20010515)91:10<1882::aid-cncr1210>3.0.co

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MAGE, BAGE andGAGE gene expression in human rhabdomyosarcomas

Autor: Angelo Rosolen, Modesto Carli, Annalisa Zambon, E. Frascella, Piero Dalerba, Beatrice Macino, Vito Ninfo, Paola Zanovello, Susanna Mandruzzato

Publikováno v: International Journal of Cancer. 93:85-90

MAGE, BAGE and GAGE genes encode tumor-associated antigens that are presented by HLA class I molecules and recognized by CD8(+) cytolytic T lymphocytes. These antigens are currently regarded as promising targets for active, specific tumor immunothera

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b32d502f511a6af481e904fb1fd0bb1
https://doi.org/10.1002/ijc.1307

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Anti‐L‐selectin monoclonal antibody treatment in mice enhances tumor growth by preventing CTL sensitization in peripheral lymph nodes draining the tumor area

Autor: Antonio Rosato, Vincenzo Bronte, Annalisa Zambon, Paola Zanovello, Dino Collavo, Gabriella Milan, Susanna Mandruzzato, Beatrice Macino

Publikováno v: International Journal of Cancer. 65:847-851

To examine the in vivo contribution of L-selectin in the sensitization of tumor-specific CTL, we investigated the effects of treatment with the anti-L-selectin monoclonal antibody (MAb) MEL-14 on the immune response to Moloney-murine sarcoma virus (M

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::20642d2bcf423a0cebf73f585305cd42
https://doi.org/10.1002/(sici)1097-0215(19960315)65:6<847::aid-ijc23>3.0.co

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Inhibition of Protein Tyrosine Phosphorylation Prevents T-Cell-Mediated Cytotoxicity

Autor: Vincenzo Bronte, Annalisa Zambon, Beatrice Macino, Antonio Rosato, Susanna Mandruzzato, Paola Zanovello, Dino Collavo, F. Calderazzo

Publikováno v: Cellular Immunology. 159:294-305

Several lines of evidence point to a central role for protein tyrosine kinases (PTKs) in the signal transduction cascade initiated by T-cell receptor (TCR) engagement. In cytotoxic T lymphocytes (CTL), TCR crosslinking leads to activation of the lyti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4292644af8a7bf216ab7b97c0abf90a
https://doi.org/10.1006/cimm.1994.1315

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Pheochromocytoma in von Hippel-Lindau disease and neurofibromatosis type 1

Autor: Beatrice Macino, Pierantonio Conton, Francesca Schiavi, Franco Mantero, Giuseppe Opocher

Clinical and genetic understanding of chromaffin tumors has been greatly enhanced in the last few years. Although some pheochromocytoma genes may still be unknown, the role of RET, VHL, SDHB, SDHD and NF1 genes is unequivocal and phenotypes are also

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34a8654a0107179a8253854e7236658d
http://hdl.handle.net/11577/2444052

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Individual analysis of mice vaccinated against a weakly immunogenic self tumor-specific antigen reveals a correlation between CD8 T cell response and antitumor efficacy

Autor: Paola Zanovello, Alessia Zoso, Beatrice Macino, Robert G. Whalen, Silvia Dalla Santa, Gabriella Milan, Valeria Tosello, Piero Musiani, Antonio Rosato, Emma Di Carlo

Publikováno v: Scopus-Elsevier

The weakly immunogenic murine P1A Ag is a useful experimental model for the development of new vaccination strategies that could potentially be used against human tumors. An i.m. DNA-based immunization procedure, consisting of three inoculations with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2d7664617111525051b011af68c4281
https://pubmed.ncbi.nlm.nih.gov/14607917

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Effective genetic vaccination with a widely shared endogenous retroviral tumor antigen requires CD40 stimulation during tumor rejection phase

Autor: Vincenzo Bronte, Ilaria Marigo, Paolo Serafini, Elisa Apolloni, Beatrice Macino, Sara Cingarlini, Carmela De Santo, Oriano Marin, Paola Zanovello

Endogenous retrovirus (ERV) products are recognized by T lymphocytes in mice and humans. As these Ags are preferentially expressed by neoplastic tissues, they might represent an ideal target for active immunization by genetic vaccination. However, i.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::153c09ae41e21d77fdaf9f66ddda01ec
http://hdl.handle.net/11562/347703

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CTL response and protection against P815 tumor challenge in mice immunized with DNA expressing the tumor-specific antigen P815A

Autor: Donna M. D'Agostino, Paola Zanovello, Antonio Rosato, Beatrice Macino, Dino Collavo, Gabriella Milan, Annalisa Zambon, Vincenzo Ciminale

Publikováno v: Human gene therapy. 8(12)

A DNA immunization approach was used to induce an immune response against the tumor-specific antigen P815A in DBA/2 mice. The P1A gene, which encodes the P815A antigen, was modified by the addition of a short sequence coding for a tag epitope recogni

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31bf818fd1bdb225e6a6aa72a48383f4
https://pubmed.ncbi.nlm.nih.gov/9287145

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The proteasome-specific inhibitor lactacystin blocks presentation of cytotoxic T lymphocyte epitopes in human and murine cells

Autor: Adam M. Benham, Siddhartha Mukherjee, Vincenzo Cerundolo, Alain Townsend, Beatrice Macino, Jacques Neefjes, Keith G. Gould, Veronique M. Braud

Publikováno v: European journal of immunology. 27(1)

We describe the effect of the proteasome specific inhibitor lactacystin on the metabolic stability of influenza nucleoprotein (NP) and on the generation of antigens presented by human and murine class I molecules of the major histocompatibility compl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe4f436c8f78359f31d292a25fcbdcc3
http://ora.ox.ac.uk/objects/uuid:43d08642-5aaf-4af0-8e01-2f223924fa1a

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