Synthesis and Characterization of a Click-Assembled 18-Atom Macrocycle That Displays Selective AXL Kinase Inhibitory Activity

Autor: Carolin Temps, Beatrice Longo, Francisco Franco-Montalban, Olga Cruz-López, Asier Unciti-Broceta, Samuel H. Myers

Publikováno v: ACS Omega, Vol 4, Iss 25, Pp 21620-21626 (2019)
López-Cruz, O, Temps, C, Longo, B, Myers, S, Franco-Montalban, F & Unciti-Broceta, A 2019, ' Synthesis and characterization of a click-assembled 18-atom macrocycle that displays selective AXL kinase inhibitory activity ', ACS Omega . https://doi.org/10.1021/acsomega.9b03525
ACS Omega
Digibug. Repositorio Institucional de la Universidad de Granada
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A novel macrocyclic construct consisting of a pyrazolopyrimidine scaffold concatenated to a benzene ring through two triazoles has been developed to investigate uncharted chemical space with bioactive potential. The 18-atom macrocycle was assembled v

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ad2f698916971cc72e3c1f8404818bd
https://doaj.org/article/d7bbf83a83494db8926d31a365016aef

Design, Synthesis, Conjugation, and Reactivity of Novel trans,trans-1,5-Cyclooctadiene-Derived Bioorthogonal Linkers

Autor: Matteo Zanda, Sergio Dall'Angelo, Albert D. Windhorst, Beatrice Longo, Chiara Zanato, Massimiliano Baldassarre, Monica Piras, Danielle J. Vugts

Publikováno v: Longo, B, Zanato, C, Piras, M, Dall'angelo, S, Windhorst, A D, Vugts, D J, Baldassarre, M & Zanda, M 2020, ' Design, Synthesis, Conjugation, and Reactivity of Novel trans,trans-1,5-Cyclooctadiene-Derived Bioorthogonal Linkers ', Bioconjugate chemistry, vol. 31, no. 9, pp. 2201-2210 . https://doi.org/10.1021/acs.bioconjchem.0c00375
Bioconjugate chemistry, 31(9), 2201-2210. American Chemical Society
Bioconjugate chemistry 31 (2020): 2201–2210. doi:10.1021/acs.bioconjchem.0c00375
info:cnr-pdr/source/autori:Longo B.; Zanato C.; Piras M.; Dall'angelo S.; Windhorst A.D.; Vugts D.J.; Baldassarre M.; Zanda M./titolo:Design, Synthesis, Conjugation, and Reactivity of Novel trans,trans-1,5-Cyclooctadiene-Derived Bioorthogonal Linkers/doi:10.1021%2Facs.bioconjchem.0c00375/rivista:Bioconjugate chemistry/anno:2020/pagina_da:2201/pagina_a:2210/intervallo_pagine:2201–2210/volume:31

The tetrazine/trans-cyclooctene (TCO) inverse electron-demand Diels-Alder (IEDDA) reaction is the fastest bioorthogonal "click"ligation process reported to date. In this context, TCO reagents have found widespread applications; however, their availab

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cea688dac66b42e463022725af2adfb
https://research.vumc.nl/en/publications/5b333705-638d-4eb3-abf3-de1adab5b3a6

Towards click pre-targeted PET imaging using novel trans-Cyclooctene linkers

Autor: Beatrice Longo

Publikováno v: Poster session EMBO Workshop-Chemical Biology 2018, Heidelberg

Poster session EMBO Workshop-Chemical Biology 2018, Heidelberg

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::994e7dec4af6b45c134433dce443dbd1
https://doi.org/10.5281/zenodo.3957631

Click pre-targeted PET imaging of antibodies using novel trans-Cyclooctene derivatives

Autor: Beatrice Longo

Monoclonal antibodies (mAbs), as vectors for delivering therapeutics or imaging agents, represent one of the most rapidly expanding tools in targeted therapy. Tracking mAbs and related constructs inside the human body could allow a better understandi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::63cc7ec683084b1af87b609bbd1b3fbb

Click pre-targeted PET imaging of antibodies using novel trans-Cyclooctene derivatives

Autor: Beatrice Longo

Oral presentation, SINAPSE Molecular Imaging PET/SPECT focus group meeting 2018, University of Glasgow

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3db6075c1aa34bd35b64f3ca6f8579de