Zobrazeno 1 - 10
of 108
pro vyhledávání: '"Beatrice L. Pool-Zobel"'
Autor:
Michael Glei, Beatrice L. Pool-Zobel, Thomas Hofmann, Stefanie Klenow, Chris I R Gill, Anke Borowicki
Publikováno v:
Genes & Nutrition. 5:309-319
Identification of chemopreventive substances may be achieved by measuring biological endpoints in human cells in vitro. Since generally only tumour cells are available for such investigations, our aim was to test the applicability of peripheral blood
Publikováno v:
British Journal of Nutrition. 102:663-671
Epidemiological evidence suggests that the intake of prebiotic dietary fibres, for example, inulin, protects against colorectal cancer. However, little is known about cellular responses to complex fermentation samples. Therefore, we prepared a fermen
Autor:
A. Schubert, Michael Glei, Chris I R Gill, A. Kuhnert, Beatrice L. Pool-Zobel, Ian Rowland, Thomas Hofmann
Publikováno v:
European Journal of Nutrition. 48:483-491
Epidemiological studies indicate that consumption of cruciferous vegetables (CV) can reduce the risk of cancer. Supposed mechanisms are partly the inhibition of phase I and the induction of phase II enzymes.The aim of this study was to investigate in
Publikováno v:
Toxicology in Vitro. 23:400-407
Increased risk for development of colon cancer is associated with red meat intake and iron toxicity is discussed for one underlying mechanism. Anyhow, for iron itself only limited evidence is found. In this study, effects of different iron compounds
Publikováno v:
Mutation Research/Reviews in Mutation Research. 681:33-43
The Comet-FISH technique is a useful tool to detect overall and region-specific DNA damage and repair in individual cells. It combines two well-established methods, the Comet assay (single cell gel electrophoresis) and the technique of fluorescence i
Autor:
Wolfgang Scheppach, Michael Glei, Beatrice L. Pool-Zobel, Selvaraju Veeriah, Kamal Kumar Balavenkatraman, Elke Richling, Frank-D. Böhmer, Kathrin Kahle
Publikováno v:
European Journal of Nutrition. 47:226-234
Apple juice is considered to be an important component of the healthy diet, with anticancer activities in colon cancer animal models and key ingredients have numerous chemoprotective activities in human colon cells in vitro.Since only little is known
Publikováno v:
Food and Chemical Toxicology. 46:1389-1397
An extract of the Mediterranean carob ( Ceratonia siliqua L. ) pod (carob fibre extract), products formed after its fermentation by the gut flora and the major phenolic ingredient gallic acid (GA), were comparatively investigated for their influence
Publikováno v:
The Journal of Nutritional Biochemistry. 18:736-745
Butyrate, a metabolite of gut flora-mediated fermentation of dietary fibre, was analysed for effects on expression of genes related to oxidative stress in primary human colon cells. An induction of detoxifying, antioxidative genes is expected to cont
Autor:
Beatrice L. Pool-Zobel, Julia Sauer
Publikováno v:
The Journal of Nutrition. 137:2580S-2584S
Colorectal cancer is related to diet, lifestyle, physical inactivity, and obesity. The responsible carcinogens cause mutations or enhance cell growth. Inulin-type fructans may counteract the effects via their gut flora-mediated fermentation products
Publikováno v:
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 619:59-67
Iron exposure enhances colorectal carcinogeneis, by producing reactive oxygen species, which damage lipids, proteins and DNA. We recently demonstrated that ferric-nitrilotriacetate (Fe-NTA) damages DNA of human colon cells in different stages of mali