Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Beatrice Guardiola"'
Autor:
Emilie Pepin, Arisa Higa, Carole Schuster-Klein, Catherine Bernard, Thierry Sulpice, Beatrice Guardiola, Eric Chevet, Thierry Alquier
Publikováno v:
PLoS ONE, Vol 9, Iss 11, p e112714 (2014)
BACKGROUND:Type 2 diabetes is characterized by pancreatic beta-cell dysfunction and is associated with low-grade inflammation. Recent observations suggest that apoptosis signal-regulating kinase 1 (ASK1) is involved in beta-cell death in response to
Externí odkaz:
https://doaj.org/article/644537aa8f6c42fe93c96b3c18b4577a
Autor:
Paul Pévet, Marie-Paule Felder-Schmittbuhl, Beatrice Guardiola, David Hicks, Paul Klosen, Carole Schuster, Sarawut Lapmanee
Publikováno v:
Journal of Pineal Research
Journal of Pineal Research, Wiley, 2019, pp.e12575. ⟨10.1111/jpi.12575⟩
Journal of Pineal Research, Wiley, 2019, 67 (1), pp.e12575. ⟨10.1111/jpi.12575⟩
Journal of Pineal Research, Wiley, 2019, pp.e12575. ⟨10.1111/jpi.12575⟩
Journal of Pineal Research, Wiley, 2019, 67 (1), pp.e12575. ⟨10.1111/jpi.12575⟩
International audience; Melatonin (MLT) exerts its physiological effects principally through two high-affinity membrane receptors MT1 and MT2. Understanding the exact mechanism of MLT action necessitates the use of highly selective agonists/antagonis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f78046425e37b8aded9d37d1e7d80e73
https://hal.archives-ouvertes.fr/hal-02403684
https://hal.archives-ouvertes.fr/hal-02403684
Autor:
Beatrice Guardiola, Wei He, Rocco Savino, Carole Schuster-Klein, Rosa Terracciano, Kathrin Maedler, Osmond D Rebello
Publikováno v:
Biochimica et biophysica acta. Molecular basis of disease. 1865(1)
Type 2 Diabetes (T2D) is strongly associated with obesity and inflammation. Toll-like receptor-4 (TLR-4) is the major pro-inflammatory pathway with its ligands and downstream products increased systemically in T2D and in at-risk individuals. Detailed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9b49d8d3133d4b4eb2eef3dd6114d4b
https://pubmed.ncbi.nlm.nih.gov/30287405
https://pubmed.ncbi.nlm.nih.gov/30287405
Autor:
Beatrice Guardiola-Lemaitre, Carmen Muńoz, Philippe Delagrange, C De Bodinat, Elisabeth Mocaer, Mark Millan
Publikováno v:
British Journal of Pharmacology. 171:3604-3619
Agomelatine behaves both as a potent agonist at melatonin MT1 and MT2 receptors and as a neutral antagonist at 5-HT2C receptors. Accumulating evidence in a broad range of experimental procedures supports the notion that the psychotropic effects of ag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5cdee1fd06a1559951a7adac465c4f3a
https://doi.org/10.1111/bph.12720
https://doi.org/10.1111/bph.12720
Autor:
Etienne Challet, François Criscuolo, Beatrice Guardiola-Lemaitre, Carole Schuster-Klein, Stéphanie Dumont, Paul Pévet, Edith Grosbellet
Publikováno v:
Biochimie
Biochimie, 2016, 124, pp.198-206. ⟨10.1016/j.biochi.2015.06.029⟩
Biochimie, Elsevier, 2016, 124, pp.198-206. ⟨10.1016/j.biochi.2015.06.029⟩
Biochimie, 2016, 124, pp.198-206. ⟨10.1016/j.biochi.2015.06.029⟩
Biochimie, Elsevier, 2016, 124, pp.198-206. ⟨10.1016/j.biochi.2015.06.029⟩
Growing evidence links metabolic disorders to circadian alterations. Genetically obese db/db mice, lacking the long isoform of leptin receptor, are a recognized model of type 2 diabetes. In this study, we aimed at characterizing the potential circadi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ef897b814f5255b6076a88a84e73519
https://hal.archives-ouvertes.fr/hal-03376582
https://hal.archives-ouvertes.fr/hal-03376582
Autor:
Paul Pévet, Etienne Challet, Helene Raingard, Carole Schuster-Klein, Rosana F. Dantas-Ferreira, Stéphanie Dumont, Beatrice Guardiola-Lemaitre
Publikováno v:
Endocrinology, Diabetes & Metabolism
Endocrinology, Diabetes & Metabolism, Wiley, 2018, 1 (4), pp.e00039. ⟨10.1002/edm2.39⟩
Endocrinology, Diabetes & Metabolism, Wiley, 2018, 1 (4), pp.e00039. ⟨10.1002/edm2.39⟩
Summary Background Melatonin is a hormone synthesized mainly by the pineal gland, and secreted only at night. Melatonin has been proposed as a modulator of glucose metabolism. Methods Here we studied the metabolic effects of melatonin administration
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04ba61b4bdcc81b782e1307d3520ab55
https://doi.org/10.1002/edm2.39
https://doi.org/10.1002/edm2.39
Autor:
Q. Cheng, Carole Schuster-Klein, Lulu Mao, Beatrice Guardiola-Lemaitre, Steven M. Hill, Ling Lai, Chunmin Dong
Publikováno v:
Journal of Pineal Research. 49:210-221
Melatonin has been shown to inhibit the proliferation of estrogen receptor α (ERα)-positive human breast cancer cells in vitro and suppress the growth of carcinogen-induced mammary tumors in rats. Melatonin's antiproliferative effect is mediated, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fd9a4cace29315c6eeb0421ddd970c70
https://doi.org/10.1111/j.1600-079x.2010.00781.x
https://doi.org/10.1111/j.1600-079x.2010.00781.x
Autor:
Millan Mark, Beatrice Guardiola-Lemaitre, Carmen Muńoz, Christian de Bodinat, Pierre Renard, Elisabeth Mocaer
Publikováno v:
Nature Reviews Drug Discovery. 9:628-642
Current management of major depression, a common and debilitating disorder with a high social and personal cost, is far from satisfactory. All available antidepressants act through monoaminergic mechanisms, so there is considerable interest in novel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4610e3c2478d34073d1ad476ec78b987
https://doi.org/10.1038/nrd3140
https://doi.org/10.1038/nrd3140
Autor:
Beatrice Guardiola-Lemaitre, Carole Schuster-Klein, Paul Pévet, Natalia Sinitskaya, Sylviane Gourmelen, Etienne Challet
Publikováno v:
Psychoneuroendocrinology. 33:1269-1278
Summary Background Photoperiod, i.e., the relative day-length per 24 h, may modulate the metabolic responses to high-fat diet (HFD) and sucrose consumption. Methods To test this hypothesis, hormonal changes, fat accretion and sucrose intake were meas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5253cf099238ccb5990ad9f7e72b0be
https://doi.org/10.1016/j.psyneuen.2008.07.003
https://doi.org/10.1016/j.psyneuen.2008.07.003
Autor:
Etienne Challet, Carole Schuster-Klein, Beatrice Guardiola-Lemaitre, François Criscuolo, Edith Grosbellet, Paul Pévet, Stéphanie Dumont
Publikováno v:
Chronobiology International
Chronobiology International, Taylor & Francis, 2015, 32 (5), pp.637-649. ⟨10.3109/07420528.2015.1035440⟩
Chronobiology International, Taylor & Francis, 2015, 32 (5), pp.637-649. ⟨10.3109/07420528.2015.1035440⟩
International audience; Leptin may affect central and/or peripheral timing, in addition to its well-known regulatory effects on metabolism. Here, we investigated whether leptin can impact rhythmicity of blood glucose and lipids. For that purpose, dai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea66bb9264f4fdd928d2a2294d70c6a0
https://hal.archives-ouvertes.fr/hal-01184015
https://hal.archives-ouvertes.fr/hal-01184015