Novel therapeutics in rare genetic obesities: A narrative review

Autor: Beatrice Dubern, Nathan Faccioli, Christine Poitou, Karine Clément

Publikováno v: Pharmacological Research, Vol 191, Iss , Pp 106763- (2023)

The better understanding of the molecular causes of rare genetic obesities and its associated phenotype involving the hypothalamus allows today to consider innovative therapeutics focused on hunger control. Several new pharmacological molecules benef

Externí odkaz: https://doaj.org/article/e7f413ffa6934d8f914bd278cb989cff

Hyperphagia and impulsivity: use of self-administered Dykens’ and in-house impulsivity questionnaires to characterize eating behaviors in children with severe and early-onset obesity

Autor: Lara Arnouk, Hélène Chantereau, Sophie Courbage, Patrick Tounian, Karine Clément, Christine Poitou, Béatrice Dubern

Publikováno v: Orphanet Journal of Rare Diseases, Vol 19, Iss 1, Pp 1-8 (2024)

Abstract Background The determinants of early-onset obesity ( International Obesity Task Force [IOTF] 30) of different etiologies (hypothalamic obesity [HO], intellectual disability with obesity [IDO], common polygenic obesity [CO]) were prospectivel

Externí odkaz: https://doaj.org/article/8921ec21cc4f4631b252d5ef89f999db

Collaborateurs

Autor: Grégoire, Benoist, Antoine, Bourrillon, Christophe, Delacourt, Christèle, Gras-Le Guen, Benoit, Billy (de), Agnès, Liard-Zmuda, Patrick, Tounian, François, Angoulvant, Jean-Baptiste, Arnoux, Frédéric, Auber, Guillaume, Aubertin, Georges, Audry, Stéphane, Auvin, Justine, Bacchetta, Martine, Balençon, Pascal, Barat, Marc, Bellaïche, Jacques, Beltrand, Etienne, Bidat, Arnaud, Bonnard, Claire, Bouvattier, Dominique, Bremond-Gignac, Frédéric, Brioude, Olivier, Brissaud, Jean-Claude, Carel, Ania, Carsin, Mireille, Castanet, Brigitte, Chabrol, Gérard, Chéron, Bertrand, Chevallier, Jacques, Cheymol, Pierre, Corre, Régis, Coutant, Laurianne, Coutier, Pierrick, Cros, Jean-Christophe, Cuvellier, Jean-Hugues, Dalle, Stéphane, Dauger, Céline, Delestrain, Amandine, Divaret-Chauveau, François, Doz, David, Drummond, Béatrice, Dubern, Sophie, Dugue, Thomas, Édouard, Brigitte, Fauroux, Albert, Faye, Pierre, Fayoux, Cyril, Flamant, Elisabeth, Fournier-Charrière, Virginie, Gandemer, Alexandra, Gauthier, Olivia, Gillion-Boyer, Lisa, Giovannini-Chami, Emmanuel, Grimprel, Alice, Hadchouel-Duvergé, Sébastien, Héritier, Christina, Ioan Iulia, Pierre-Henri, Jarreau, Etienne, Javouhey, Eric, Jeziorski, Elsa, Kermorvant, Béatrice, Kugener, François, Labarthe, André, Labbé, Géraldine, Labouret, Elise, Launay, Rémi, Laporte, Nicolas, Leboulanger, Joël, Lechevallier, Juliane, Léger, Stéphanie, Lejeune, Stéphanie, Leroux, Guillaume, Lezmi, Anne, Lienhardt-Roussie, Agnès, Linglart, Mathie, Lorrot, Natalie, Loundon, Jehanne, Malek, Christophe, Marguet, Aude, Marie Cardine, Laetitia, Martinerie, Emmanuel, Mas, Thierry, Merrot, Matthieu, Milh, Despina, Moshous, Pierre-Yves, Mure, Javotte, Nancy, Nadia, Nathan, Irene, Netchine, Marc, Nicolino, Richard, Nicollas, Sylvie, Odent, Caroline, Ovaert, Françoise, Paris, Laurent, Pasquier, Aurélie, Phulpin, Capucine, Picard, Georges, Picherot, Guillaume, Podevin, Michel, Polak, Philippe, Ravasse, Rachel, Reynaud, Sylvie, Rossignol, Sébastien, Rouget, Jean-Christophe, Rozé, Philippe, Sachs, Frédérique, Sauvat, Cyril, Schweitzer, Isabelle, Sermet-Gaudelus, Chantal, Stheneur, Isabelle, Talon, Aline, Tamalet, Maïté, Tauber, Jessica, Taytard, Jean-Benoît, Thambo, Caroline, Thumerelle, Renaud, Tournemire (de), Barbara, Tourniaire, Michel, Tsimaratos, François, Varlet, Alain, Verloes, Ariane, Zaloszyc, Catherine, Cyteval, Philippe, Petit, Damien, Bonnard, Emmanuel, Lescanne

Publikováno v: In Pédiatrie Edition: Eighth Edition. 2020:xxix-xxxii

Genetics of Obesity

Autor: Beatrice Dubern, Patrick Tounian

Publikováno v: Adipose Tissue and Adipokines in Health and Disease ISBN: 9781627037693

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4bd14291d3b799b20ea72d1fd2ab9cc2
https://doi.org/10.1007/978-1-62703-770-9_12

Evaluation of a melanocortin-4 receptor (MC4R) agonist (Setmelanotide) in MC4R deficiency

Autor: Tinh-Hai Collet, Béatrice Dubern, Jacek Mokrosinski, Hillori Connors, Julia M. Keogh, Edson Mendes de Oliveira, Elana Henning, Christine Poitou-Bernert, Jean-Michel Oppert, Patrick Tounian, Florence Marchelli, Rohia Alili, Johanne Le Beyec, Dominique Pépin, Jean-Marc Lacorte, Andrew Gottesdiener, Rebecca Bounds, Shubh Sharma, Cathy Folster, Bart Henderson, Stephen O'Rahilly, Elizabeth Stoner, Keith Gottesdiener, Brandon L. Panaro, Roger D. Cone, Karine Clément, I. Sadaf Farooqi, Lex H.T. Van der Ploeg

Publikováno v: Molecular Metabolism, Vol 6, Iss 10, Pp 1321-1329 (2017)

Objective: Pro-opiomelanocortin (POMC)-derived peptides act on neurons expressing the Melanocortin 4 receptor (MC4R) to reduce body weight. Setmelanotide is a highly potent MC4R agonist that leads to weight loss in diet-induced obese animals and in o

Externí odkaz: https://doaj.org/article/c5eaa2749c7940ff9fd0b329019b8d26