Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Beatrice B. Taite"'
Publikováno v:
Journal of Thrombosis and Thrombolysis. 14:113-121
The Tissue Factor/Factor VIIa (TF/FVIIa) complex is an attractive target for pharmacological interruption of thrombin generation and hence blood coagulation, as this complex is the initiation point of the extrinsic pathway of coagulation. TF is a cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e157b22355e82669e3aed476ca94bb35
https://doi.org/10.1023/a:1023228827733
https://doi.org/10.1023/a:1023228827733
Autor:
Jeffery Alan Zablocki, Neal F. Haas, Anita K. Salyers, S.G. Panzer-Knodle, Beatrice B. Taite, Larry P. Feigen, Marc Herin, Kay Broschat, Lucy W. King, Phillipe Jacqmin, Bradley T. Keller, V. Wayne Engleman, Nancy S. Nicholson, James A. Szalony
Publikováno v:
Circulation. 91:403-410
Background Intravenous therapy has been shown to be beneficial in the prevention of acute platelet-associated thrombotic events. However, orally active agents would be advantageous for chronic therapy. Fibrinogen receptor antagonists block the fibrin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::336714372463ad6d39ffad92b62638ee
https://doi.org/10.1161/01.cir.91.2.403
https://doi.org/10.1161/01.cir.91.2.403
Autor:
Dudley E. McMackins, Mihaly V. Toth, Henry E. Dayringer, J. G. Rico, P. R. Bovy, Nancy S. Nicholson, Anita K. Salyers, Beatrice B. Taite, Jeffery Alan Zablocki, Larry P. Feigen, Thomas E. Rogers, Shashidhar N. Rao, Mark E. Zupec, Robert Bruce Garland, Steven Paul Adams, M. Herin, R. J. Lindmark, Foe S. Tjoeng, S.G. Panzer-Knodle, Masateru Miyano
Publikováno v:
Bioorganic & Medicinal Chemistry. 2:881-895
The evolutionary process from the Arg-Gly-Asp-Phe (RGDF) tetrapeptide to potent orally active anti-platelet agents is presented. The RGD sequence is an important component in the recognition of fibrinogen by its platelet receptor GP IIb-IIIa (integri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82ff7ca1e73492c493b88cb344c8d089
https://doi.org/10.1016/s0968-0896(00)82038-6
https://doi.org/10.1016/s0968-0896(00)82038-6
Autor:
Nancy S. Nicholson, Jeffery Alan Zablocki, R. J. Lindmark, D Pireh, Robert Bruce Garland, Beatrice B. Taite, Masateru Miyano, Shashidhar N. Rao, L Schretzman, S.G. Panzer-Knodle
Publikováno v:
Journal of Medicinal Chemistry. 36:1811-1819
Peptide mimetics of the RGDF sequence in which Arg-Gly has been replaced with 5-(4-amidinophenyl)pentanoyl mimetic has led to a 1000-fold increase in inhibitory potency over the natural RGDF ligand. The guanidine residue of the arginine may be involv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d418001710ed44efdbaa4f9aa830654d
https://doi.org/10.1021/jm00065a003
https://doi.org/10.1021/jm00065a003
Autor:
Norman A. Abood, Anita K. Salyers, Beatrice B. Taite, Susan G. Panzer-Knodle, Osman D. Suleymanov, Nancy S. Nicholson, Leo G. Frederick, Robert J. Anders, James A. Szalony, Jimmy D. Page
Publikováno v:
ChemInform. 32
A key role has been established for platelet activation and thrombus formation in the pathogenesis of acute coronary syndromes, and restenosis after percutaneous interventions. Antiplatelet agents that have a wider spectrum of activity than aspirin,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::612943204336f54d9eb2fc9fd7c09e63
https://doi.org/10.1002/chin.200127240
https://doi.org/10.1002/chin.200127240
Autor:
James A, Szalony, Beatrice B, Taite, Thomas J, Girard, Nancy S, Nicholson, Rhonda M, LaChance
Publikováno v:
Journal of thrombosis and thrombolysis. 14(2)
The Tissue Factor/Factor VIIa (TF/FVIIa) complex is an attractive target for pharmacological interruption of thrombin generation and hence blood coagulation, as this complex is the initiation point of the extrinsic pathway of coagulation. TF is a cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f9cb62dbfdba309a834d45bc70b7c986
https://pubmed.ncbi.nlm.nih.gov/12714830
https://pubmed.ncbi.nlm.nih.gov/12714830
Autor:
Robert J. Anders, Susan G. Panzer-Knodle, Jimmy D. Page, Nancy S. Nicholson, Beatrice B. Taite, Norman A. Abood, Anita K. Salyers, Osman D. Suleymanov, Leo G. Frederick, James A. Szalony
Publikováno v:
Medicinal research reviews. 21(3)
A key role has been established for platelet activation and thrombus formation in the pathogenesis of acute coronary syndromes, and restenosis after percutaneous interventions. Antiplatelet agents that have a wider spectrum of activity than aspirin,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87aae3f2b09cb3b7546fdafb71fc374c
https://pubmed.ncbi.nlm.nih.gov/11301411
https://pubmed.ncbi.nlm.nih.gov/11301411
Autor:
Larry P. Feigen, Leo G. Frederick, James A. Szalony, Lucy W. King, Nancy S. Nicholson, Anita K. Salyers, Osman D. Suleymanov, Beatrice B. Taite
Publikováno v:
Circulation. 98(8)
Background —Inhibition of platelet aggregation by preventing the binding of fibrinogen to glycoprotein (GP) IIb/IIIa on activated platelets results in antithrombotic activity. We report on the antithrombotic effect of xemilofiban (SC-54684A), an or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dffe22c0e819358242abf0fefbc14bf7
https://pubmed.ncbi.nlm.nih.gov/9727553
https://pubmed.ncbi.nlm.nih.gov/9727553
Autor:
Neal F. Haas, David M. Lansky, Beatrice B. Taite, Nancy S. Nicholson, Anita K. Salyers, Jimmy D. Page, James A. Szalony, Larry P. Feigen, S.G. Panzer-Knodle
Publikováno v:
American heart journal. 135(5 Pt 2)
Optical aggregometry, traditionally used to assess platelet function, is highly dependent on sample preparation and technical procedure; as a result, data from various laboratories can be quite variable. In a study designed to assess the sources of v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b18d211dcd17134dbeeb8a43003dfd35
https://pubmed.ncbi.nlm.nih.gov/9588396
https://pubmed.ncbi.nlm.nih.gov/9588396
Autor:
Nancy S. Nicholson, J. G. Rico, Kenneth Williams, Foe S. Tjoeng, P. R. Bovy, Lucy W. King, Anita K. Salyers, Lori Ann Schretzman, Beatrice B. Taite, Robert B. Garland, Masateru Miyano, Susan G. Panzer-Knodle, Jeffery A. Zablocki, R. J. Lindmark, Mihaly V. Toth, Dudley E. McMackins, James G. Campion, Mark E. Zupec, Larry P. Feigen, Steven Paul Adams
Publikováno v:
Bioorganicmedicinal chemistry. 3(5)
A novel series of orally active fibrinogen receptor antagonists has been discovered through structural modification of our lead intravenous (iv) antiplatelet agent, 5-(4-amidinophenyl)pentanoyl-Asp-Phe 1 (SC-52012). The Asp-Phe amide bond was removed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::457021deb18f6befd4e2a794535a39c6
https://pubmed.ncbi.nlm.nih.gov/7648203
https://pubmed.ncbi.nlm.nih.gov/7648203