Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Beatrice A. Nyagode"'
Autor:
Sylvie M. Mimche, Choon-myung Lee, Ken H. Liu, Patrice N. Mimche, R. Donald Harvey, Thomas J. Murphy, Beatrice A. Nyagode, Dean P. Jones, Tracey J. Lamb, Edward T. Morgan
Publikováno v:
Malaria Journal, Vol 18, Iss 1, Pp 1-16 (2019)
Abstract Background Given the central importance of anti-malarial drugs in the treatment of malaria, there is a need to understand the effect of Plasmodium infection on the broad spectrum of drug metabolizing enzymes. Previous studies have shown redu
Externí odkaz:
https://doaj.org/article/391564a345ce4823927cc7605d2c0191
Autor:
Beatrice A. Nyagode, Edward T. Morgan, R. Donald Harvey, Choon-Myung Lee, T. J. Murphy, Dean P. Jones, Patrice N. Mimche, Ken H. Liu, Tracey J. Lamb, Sylvie M. Mimche
Publikováno v:
Malaria Journal
Malaria Journal, Vol 18, Iss 1, Pp 1-16 (2019)
Malaria Journal, Vol 18, Iss 1, Pp 1-16 (2019)
Background Given the central importance of anti-malarial drugs in the treatment of malaria, there is a need to understand the effect of Plasmodium infection on the broad spectrum of drug metabolizing enzymes. Previous studies have shown reduced clear
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f837ce0bb5221400e0983d69ddb8b81c
https://pubmed.ncbi.nlm.nih.gov/31299982
https://pubmed.ncbi.nlm.nih.gov/31299982
Publikováno v:
Inflammation. 37:893-907
Murine hepatic Cyp4a mRNAs are markedly downregulated during inflammation. Here, we investigated the roles of Cyp4a10 and Cyp4a14 in the response to infection with C. rodentium. Absence of either Cyp4a gene attenuated or abrogated the changes in sple
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da77de7f1c22c64e61b0c29a9a79fe68
https://doi.org/10.1007/s10753-013-9809-6
https://doi.org/10.1007/s10753-013-9809-6
Autor:
Edward T. Morgan, John D. Clarke, Matthew D. Merrell, Nathan J. Cherrington, Beatrice A. Nyagode
Publikováno v:
Drug Metabolism and Disposition. 42:596-602
Various disease models have been shown to alter hepatic drug-metabolizing enzyme (DME) and transporter expression and to induce cholestasis through altered enzyme and transporter expression. Previously, we detailed the regulation of hepatic DMEs duri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19873329248c929069203fdc7167ad2c
https://doi.org/10.1124/dmd.113.055525
https://doi.org/10.1124/dmd.113.055525
Autor:
Richard D. Cummings, Beatrice A. Nyagode, Nina Salinger Prasanphanich, Choon-Myung Lee, Matthew D. Merrell, Edward T. Morgan, Sylvie M. Mimche
Publikováno v:
Drug Metabolism and Disposition. 42:134-140
Inflammation and infection downregulate the activity and expression of cytochrome P450s (P450s) and other drug metabolizing enzymes (DMEs) involved in hepatic drug clearance. Schistosoma mansoni infection was reported to cause a downregulation of hep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf1104c83b1a33332ae6e87ec2ec64c8
https://doi.org/10.1124/dmd.113.054957
https://doi.org/10.1124/dmd.113.054957
Publikováno v:
Drug Metabolism and Disposition. 40:1894-1899
The profile of selective modulation of hepatic cytochrome P450 (P450) gene expression caused by infection with the murine intestinal pathogen Citrobacter rodentium has been well characterized in multiple genetic backgrounds; yet, the mechanisms under
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eecf4567cd9224fc7f23eea840f5285d
https://doi.org/10.1124/dmd.112.046557
https://doi.org/10.1124/dmd.112.046557
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 335:480-488
After infection with Citrobacter rodentium, murine hepatic cytochrome P450 (P450) mRNAs are selectively regulated. Several serum proinflammatory cytokines are elevated, the most abundant being interleukin-6 (IL6). To elucidate the role of cytokines i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7dfd82ddd6f94ad5649330527933c908
https://doi.org/10.1124/jpet.110.171488
https://doi.org/10.1124/jpet.110.171488
Autor:
Roya Jahangardi, Edward T. Morgan, MariadeLourdes Tansey, Matthew D. Merrell, Beatrice A. Nyagode
Publikováno v:
Pharmacology Research & Perspectives
We studied the impact of administering XPro1595, a novel antagonist of soluble tumor necrosis factor-α(TNFα), on the regulation of hepatic cytochrome P450 enzymes in the Citrobacter rodentium model of infectious colitis. XPro1595 was administered s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abf8acf8bbeb2bbb300eb160d5ffa777
https://doi.org/10.1002/prp2.27
https://doi.org/10.1002/prp2.27
Publikováno v:
The FASEB Journal. 26
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::30aae04614f465fab3f30769ec1b7e58
https://doi.org/10.1096/fasebj.26.1_supplement.673.12
https://doi.org/10.1096/fasebj.26.1_supplement.673.12
Under conditions of innate immune system activation (i.e., inflammation), the functions of specific cytochrome P450 enzymes, other drug metabolizing enzymes (DMEs), and drug transporters (DTs) are altered in the liver, small intestine, lung, kidney,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dc98118a91e696dc65ba65d0cf1dda76
https://doi.org/10.1002/9780470921920.edm089
https://doi.org/10.1002/9780470921920.edm089
