Výsledky vyhledávání - "Beate Ritz-Laser"

Ectopic expression of the beta-cell specific transcription factor Pdx1 inhibits glucagon gene transcription

Autor: Philippe A. Halban, Beate Ritz-Laser, Benoit R. Gauthier, Jacques Philippe, Didier Trono, Aline Mamin, Anne Estreicher, Frédéric Ris, Thierry Brun, Patrick Salmon

Publikováno v: Diabetologia, Vol. 46, No 6 (2003) pp. 810-821

AIMS/HYPOTHESIS: The transcription factor Pdx1 is required for the development and differentiation of all pancreatic cells. Beta-cell specific inactivation of Pdx1 in developing or adult mice leads to an increase in glucagon-expressing cells, suggest

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6506f941058bd9a4df594566d7c8d3a5
https://doi.org/10.1007/s00125-003-1115-7

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Autor: Maria I. Vaccaro, Albrecht Hoffmeister, Alejandro Ropolo, Jean Charles Dagorn, Sophie Vasseur, Gustavo V. Mallo, Juan L. Iovanna, Beate Ritz-Laser, Hans Bödeker, Gregory R. Dressler, Silvia N.J. Moreno

Publikováno v: Journal of Biological Chemistry. 277:22314-22319

p8 is a nuclear DNA-binding protein, which was identified because its expression is strongly activated in response to several stresses. Biochemical and biophysical studies revealed that despite a weak sequence homology p8 is an HMG-I/Y-like protein,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2295be062f839630580e2954cac23d47
https://doi.org/10.1074/jbc.m201657200

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The pancreatic beta-cell-specific transcription factor Pax-4 inhibits glucagon gene expression through Pax-6

Autor: Aline Mamin, Helena Edlund, Jacques Philippe, Anne Estreicher, Benoit R. Gauthier, Beate Ritz-Laser

Publikováno v: Diabetologia. 45:97-107

The paired-homeobox genes pax-4 and pax-6 are crucial for islet development; whereas the null mutation of pax-6 results in the nearly absence of glucagon-producing α cells, pax-4 homozygous mutant mice lack insulin and somatostatin-producing beta an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93119dd4fcbde9dab7f6c2c96c40dc93
https://doi.org/10.1007/s125-002-8249-9

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Pdx1 Level Defines Pancreatic Gene Expression Pattern and Cell Lineage Differentiation

Autor: Haiyan Wang, Beate Ritz-Laser, Claes B. Wollheim, Hisamitsu Ishihara, Kerstin A. Hagenfeldt, Jacques Philippe, Pierre Maechler

Publikováno v: Journal of Biological Chemistry, Vol. 276, No 27 (2001) pp. 25279-86

The absence of Pdx1 and the expression of brain-4 distinguish alpha-cells from other pancreatic endocrine cell lineages. To define the transcription factor responsible for pancreatic cell differentiation, we employed the reverse tetracycline-dependen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8762477d178f25d36062de96ed9eff22
https://doi.org/10.1074/jbc.m101233200

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Glucose Regulates Proinsulin and Prosomatostatin But Not Proglucagon Messenger Ribonucleic Acid Levels in Rat Pancreatic Islets1

Autor: Beate Ritz-Laser, Paolo Meda, Alain Ktorza, Christophe Magnan, Eric Dumonteil, Jacques Philippe

Publikováno v: Endocrinology. 141:174-180

Insulin and glucagon are the major hormones involved in the control of fuel metabolism and particularly of glucose homeostasis; in turn, nutrients tightly regulate insulin and glucagon secretion from the islets of Langerhans. Nutrients have clearly b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::61c2c3c25896ab54fcb4143a4a515eda
https://doi.org/10.1210/endo.141.1.7230

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Chronic Exposure to High Glucose Concentrations Increases Proglucagon Messenger Ribonucleic Acid Levels and Glucagon Release from InR1G9 Cells1

Autor: Chistophe Magnan, Iléana Grigorescu, Jacques Philippe, Eric Dumonteil, Beate Ritz-Laser, Alain Ktorza

Publikováno v: Endocrinology. 140:4644-4650

α cell function is impaired in diabetes. In diabetics, plasma levels of glucagon are high despite persistently elevated glucose levels and may even rise paradoxically in response to a glucose load; high plasma glucagon levels are accompanied by incr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7053b8bcd49e949c001f67b10d22a98a
https://doi.org/10.1210/endo.140.10.7052

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Detection of insulin mRNA in the peripheral blood after human islet transplantion predicts deterioration of metabolic control

Autor: Thierry Berney, Philippe Morel, A. M. James Shapiro, P.Y. Benhamou, M-C Brulhart, Domenico Bosco, Jacques Philippe, Christian Toso, Anne Wojtusciszyn, Mathieu Pierre Jean Armanet, Reto M. Baertschiger, Aline Mamin, Sandrine Demuylder-Mischler, Beate Ritz-Laser

Publikováno v: American Journal of Transplantation, Vol. 6, No 7 (2006) pp. 1704-11
BASE-Bielefeld Academic Search Engine
American Journal of Transplantation
American Journal of Transplantation, Wiley, 2006, 6 (7), pp.1704-11. ⟨10.1111/j.1600-6143.2006.01373.x⟩

International audience; Recent updates of the Edmonton trial have shown that insulin independence is progressively lost in approximately 90% of islet transplant recipients over the first 5 years. Early prediction of islet graft injury could prompt th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61f4c7513b778062811d4f482d24ad37
https://archive-ouverte.unige.ch/unige:35715

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Essential interaction of Egr-1 at an islet-specific response element for basal and gastrin-dependent glucagon gene transactivation in pancreatic alpha-cells

Autor: Jacques Philippe, Emmanuelle Roulet, Chantal Escrieut, Beate Ritz-Laser, Sophie Marchal-Victorion, Lucien Pradayrol, Stéphane Leung-Theung-Long, Marlène Dufresne, Pascal Clerc, Daniel Fourmy, Catherine Seva

Publikováno v: The Journal of biological chemistry. 280(9)

The peptide hormone gastrin is secreted from G cells of the gastric antrum and is the main inducer of gastric acid secretion via activation of its receptor the cholecystokinin 2 (CCK2) receptor. Both gastrin and CCK2 receptors are also transiently de

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b501546f70ca52e7689eb017029110e1
https://pubmed.ncbi.nlm.nih.gov/15611055

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The zinc finger-containing transcription factor Gata-4 is expressed in the developing endocrine pancreas and activates glucagon gene expression

Autor: Beate Ritz-Laser, Jacques Philippe, Thierry Brun, Aline Mamin, Valerie M. Schwitzgebel, Isabelle Avril

Publikováno v: Molecular Endocrinology, Vol. 19, No 3 (2005) pp. 759-70

Gene inactivation studies have shown that members of the Gata family of transcription factors are critical for endoderm development throughout evolution. We show here that Gata-4 and/or Gata-6 are not only expressed in the adult exocrine pancreas but

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cc281d2991597a8b6d147902f8de3a3
https://pubmed.ncbi.nlm.nih.gov/15539431

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