Zobrazeno 1 - 10
of 81
pro vyhledávání: '"Beate M Kümmerer"'
Autor:
Vasiliya Kril, Michael Hons, Celine Amadori, Claire Zimberger, Laurine Couture, Yara Bouery, Julien Burlaud-Gaillard, Andrei Karpov, Denis Ptchelkine, Alexandra L. Thienel, Beate M. Kümmerer, Ambroise Desfosses, Rhian Jones, Philippe Roingeard, Laurent Meertens, Ali Amara, Juan Reguera
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Alphaviruses, such as chikungunya virus (CHIKV), are mosquito-borne viruses that represent a significant threat to human health due to the current context of global warming. Efficient alphavirus infection relies on the activity of the non-st
Externí odkaz:
https://doaj.org/article/392f25030b2e4f8f892df5a32b1b2c86
Autor:
Vánio André Mugabe, Sadia Ali, Imelda Chelene, Vanessa Onofre Monteiro, Onélia Guiliche, Argentina Felisbela Muianga, Flora Mula, Virgílio António, Inocêncio Chongo, John Oludele, Kerstin Falk, Igor A Paploski, Mitermayer G Reis, Uriel Kitron, Beate M Kümmerer, Guilherme S Ribeiro, Eduardo Samo Gudo
Publikováno v:
PLoS ONE, Vol 13, Iss 2, p e0192110 (2018)
In January 2016, health authorities from Zambézia province, Mozambique reported the detection of some patients presenting with fever, arthralgia, and a positive result for chikungunya in an IgM-based Rapid Diagnostic Test (RDT). We initiated a study
Externí odkaz:
https://doaj.org/article/7a94aba1165a4cf59c978b4b485b5bcd
Autor:
Antonio Santos-Peral, Fabian Luppa, Sebastian Goresch, Elena Nikolova, Magdalena Zaucha, Lisa Lehmann, Frank Dahlstroem, Hadi Karimzadeh, Julia Thorn-Seshold, Elena Winheim, Ev-Marie Schuster, Gerhard Dobler, Michael Hoelscher, Beate M. Kümmerer, Stefan Endres, Kilian Schober, Anne B. Krug, Michael Pritsch, Giovanna Barba-Spaeth, Simon Rothenfusser
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract The yellow fever 17D vaccine (YF17D) is highly effective but is frequently administered to individuals with pre-existing cross-reactive immunity, potentially impacting their immune responses. Here, we investigate the impact of pre-existing f
Externí odkaz:
https://doaj.org/article/0cc439cc069c4608a03f5cbc55f045c0
TMPRSS2 isoform 1 downregulation by G-quadruplex stabilization induces SARS-CoV-2 replication arrest
Autor:
Alessio De Magis, Philipp Schult, Antonia Schönleber, Rebecca Linke, Kerstin U. Ludwig, Beate M. Kümmerer, Katrin Paeschke
Publikováno v:
BMC Biology, Vol 22, Iss 1, Pp 1-18 (2024)
Abstract Background SARS-CoV-2 infection depends on the host cell factors angiotensin-converting enzyme 2, ACE2, and the transmembrane serinprotease 2, TMPRSS2. Potential inhibitors of these proteins would be ideal targets against severe acute respir
Externí odkaz:
https://doaj.org/article/482e5826db224a729a72cbb3f46861e9
Autor:
Jan Felix Drexler, Victor Max Corman, Marcel Alexander Müller, Alexander N Lukashev, Anatoly Gmyl, Bruno Coutard, Alexander Adam, Daniel Ritz, Lonneke M Leijten, Debby van Riel, Rene Kallies, Stefan M Klose, Florian Gloza-Rausch, Tabea Binger, Augustina Annan, Yaw Adu-Sarkodie, Samuel Oppong, Mathieu Bourgarel, Daniel Rupp, Bernd Hoffmann, Mathias Schlegel, Beate M Kümmerer, Detlev H Krüger, Jonas Schmidt-Chanasit, Alvaro Aguilar Setién, Veronika M Cottontail, Thiravat Hemachudha, Supaporn Wacharapluesadee, Klaus Osterrieder, Ralf Bartenschlager, Sonja Matthee, Martin Beer, Thijs Kuiken, Chantal Reusken, Eric M Leroy, Rainer G Ulrich, Christian Drosten
Publikováno v:
PLoS Pathogens, Vol 9, Iss 6, p e1003438 (2013)
Hepatitis C virus (HCV) is among the most relevant causes of liver cirrhosis and hepatocellular carcinoma. Research is complicated by a lack of accessible small animal models. The systematic investigation of viruses of small mammals could guide effor
Externí odkaz:
https://doaj.org/article/9d69d55584884b4f8a36a3eb0a8044b1
Autor:
Celia Pedroso, Carlo Fischer, Marie Feldmann, Manoel Sarno, Estela Luz, Andrés Moreira-Soto, Renata Cabral, Eduardo Martins Netto, Carlos Brites, Beate M. Kümmerer, Jan Felix Drexler
Publikováno v:
Emerging Infectious Diseases, Vol 25, Iss 8, Pp 1485-1493 (2019)
The Zika virus outbreak in Latin America resulted in congenital malformations, called congenital Zika syndrome (CZS). For unknown reasons, CZS incidence was highest in northeastern Brazil; one potential explanation is that dengue virus (DENV)–media
Externí odkaz:
https://doaj.org/article/2cc23ba0191d40d9b175ba7d50e43eed
Autor:
Carlo Fischer, Celia Pedroso, Alfredo Mendrone, Ana Maria Bispo de Filippis, Antonio Carlos Rosário Vallinoto, Bergmann Morais Ribeiro, Edison Luiz Durigon, Ernesto T.A. Marques, Gubio S. Campos, Isabelle F.T. Viana, José Eduardo Levi, Luciano Cesar Scarpelli, Mauricio Lacerda Nogueira, Michele de Souza Bastos, Nathalia C. Santiago Souza, Ricardo Khouri, Sanny M. Costa Lira, Shirley Vasconcelos Komninakis, Cécile Baronti, Rémi N. Charrel, Beate M. Kümmerer, Christian Drosten, Carlos Brites, Xavier de Lamballerie, Matthias Niedrig, Eduardo Martins Netto, Jan Felix Drexler
Publikováno v:
Emerging Infectious Diseases, Vol 24, Iss 5, Pp 888-892 (2018)
We conducted an external quality assessment of Zika virus molecular diagnostic tests in Brazil using a new Zika virus standard. Of 15 laboratories, 73% showed limited sensitivity and specificity. Viral load estimates varied significantly. Continuous
Externí odkaz:
https://doaj.org/article/e1029091894c47c69cbc815d728a1b4a
Autor:
Mohamed Lamine Hafirassou, Laurent Meertens, Claudia Umaña-Diaz, Athena Labeau, Ophelie Dejarnac, Lucie Bonnet-Madin, Beate M. Kümmerer, Constance Delaugerre, Philippe Roingeard, Pierre-Olivier Vidalain, Ali Amara
Publikováno v:
Cell Reports, Vol 21, Iss 13, Pp 3900-3913 (2017)
Dengue virus (DENV) infections cause the most prevalent mosquito-borne viral disease worldwide, for which no therapies are available. DENV encodes seven non-structural (NS) proteins that co-assemble and recruit poorly characterized host factors to fo
Externí odkaz:
https://doaj.org/article/9295f85e2011437aab1ee7596f776278
Autor:
Carlo Fischer, Maria C. Torres, Pranav Patel, Andres Moreira-Soto, Ernest A. Gould, Rémi N. Charrel, Xavier de Lamballerie, Rita Maria Ribeiro Nogueira, Patricia C. Sequeira, Cintia D.S. Rodrigues, Beate M. Kümmerer, Christian Drosten, Olfert Landt, Ana Maria Bispo de Filippis, Jan Felix Drexler
Publikováno v:
Emerging Infectious Diseases, Vol 23, Iss 11, Pp 1867-1871 (2017)
The current yellow fever outbreak in Brazil prompted widespread yellow fever virus (YFV) vaccination campaigns, imposing a responsibility to distinguish between vaccine- and wild-type YFV-associated disease. We developed novel multiplex real-time rev
Externí odkaz:
https://doaj.org/article/f5e32ac2e6a14bf29cccccdc0e91f77b
Autor:
Christoph Coch, Benjamin Hommertgen, Thomas Zillinger, Juliane Daßler-Plenker, Bastian Putschli, Maximilian Nastaly, Beate M. Kümmerer, Johanna F. Scheunemann, Beatrix Schumak, Sabine Specht, Martin Schlee, Winfried Barchet, Achim Hoerauf, Eva Bartok, Gunther Hartmann
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
During blood-stage malaria, the innate immune system initiates the production of pro-inflammatory cytokines, including IFN-γ, that are critical to host defense and responsible for severe disease. Nonetheless, the innate immune pathways activated dur
Externí odkaz:
https://doaj.org/article/02c8566af8ae41498b09c31bd0928bb9