Zobrazeno 1 - 10
of 178
pro vyhledávání: '"Beate Fißlthaler"'
Autor:
Clara Meier, Gianluca La Rocca, Virginia Nawrot, Beate Fißlthaler, Sarah J. Overby, Kai Hourfar, Guido Plotz, Christian Seidl, Paul Ziegler, Peter Wild, Stefan Zeuzem, Jürgen Brieger, Elke Jäger, Achim Battmann, Angela Brieger
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 11, p 5658 (2024)
Tumor recurrence and drug resistance are responsible for poor prognosis in colorectal cancer (CRC). DNA mismatch repair (MMR) deficiency or elevated interleukin-8 (IL-8) levels are characteristics of CRCs, which have been independently correlated wit
Externí odkaz:
https://doaj.org/article/c4c607a390d94b0c838e4d6798b65be9
Autor:
Jiong Hu, Marco Sisignano, Roman Brecht, Natarajan Perumal, Carlo Angioni, Iris-Sofia Bibli, Beate Fisslthaler, Hartmut Kleinert, Norbert Pfeiffer, Ingrid Fleming, Caroline Manicam
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract Cytochrome P450 (CYP) signalling pathway has been shown to play a vital role in the vasoreactivity of wild type mouse ophthalmic artery. In this study, we determined the expression, vascular responses and potential mechanisms of the CYP-deri
Externí odkaz:
https://doaj.org/article/7c86336bfbe8447db07c79cc9df5eb60
Autor:
Ürün Ukan, Fredy Delgado Lagos, Sebastian Kempf, Stefan Günther, Mauro Siragusa, Beate Fisslthaler, Ingrid Fleming
Publikováno v:
Cells, Vol 11, Iss 10, p 1718 (2022)
Macrophages are plastic and heterogeneous immune cells that adapt pro- or anti-inflammatory phenotypes upon exposure to different stimuli. Even though there has been evidence supporting a crosstalk between coagulation and innate immunity, the way in
Externí odkaz:
https://doaj.org/article/760a9fcd09f742e8a50ee2e54fb0ed91
Autor:
Sofia-Iris Bibli, Jiong Hu, Matthias S. Leisegang, Janina Wittig, Sven Zukunft, Andrea Kapasakalidi, Beate Fisslthaler, Diamantis Tsilimigras, Georgios Zografos, Konstantinos Filis, Ralf P. Brandes, Andreas Papapetropoulos, Fragiska Sigala, Ingrid Fleming
Publikováno v:
Redox Biology, Vol 28, Iss , Pp - (2020)
Cystathionine γ lyase (CSE) is the major source of hydrogen sulfide-derived species (H2Sn) in endothelial cells and plays an important role in protecting against atherosclerosis. Here we investigated the molecular mechanisms underlying the regulatio
Externí odkaz:
https://doaj.org/article/b82f9f2169ae4462a428be0f43fcc28e
Autor:
Hebatullah Laban, Sophia Siegmund, Maren Zappe, Felix A. Trogisch, Jörg Heineke, Carolina De La Torre, Beate Fisslthaler, Caroline Arnold, Jonathan Lauryn, Michael Büttner, Carolin Mogler, Katsuhiro Kato, Ralf H. Adams, Hanna Kuk, Andreas Fischer, Markus Hecker, Wolfgang M. Kuebler, Thomas Korff
Publikováno v:
Cells, Vol 10, Iss 12, p 3293 (2021)
Chronic hypoxia increases the resistance of pulmonary arteries by stimulating their contraction and augmenting their coverage by smooth muscle cells (SMCs). While these responses require adjustment of the vascular SMC transcriptome, regulatory elemen
Externí odkaz:
https://doaj.org/article/22f10cee3fa44f04945aaf2d450d6043
Autor:
Dagmar Meyer zu Heringdorf, Corina Ratiu, Amro Elgheznawy, Voahanginirina Randriamboavonjy, Anastasia Kyselova, Ingrid Fleming, Mauro Siragusa, Alexander W. Mann, Beate Fisslthaler, Fredy Delgado Lagos
Publikováno v:
Blood. 137:1641-1651
Secreted modular calcium-binding protein 1 (SMOC1) is an osteonectin/SPARC-related matricellular protein, whose expression is regulated by microRNA-223 (miR-223). Given that platelets are rich in miR-223, this study investigated the expression of SMO
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bcf0b32aeb935a44038d5325894fca8
https://doi.org/10.1182/blood.2020009405
https://doi.org/10.1182/blood.2020009405
Autor:
Mario Looso, Stefan Offermanns, Lukas Tombor, Voahanginirina Randriamboavonjy, Philipp Goymann, Anastasia Kyselova, Stephen L. Nishimura, Stefanie Dimmeler, Alberto Fernando Oliveira Justo, Matthias S. Leisegang, Sven Zukunft, Andreas Weigert, Andreas Papapetropoulos, Beate Fisslthaler, Sofia-Iris Bibli, Juliana Heidler, Janina Wittig, Ingrid Fleming, Corina Ratiu, Jiong Hu, Fragiska Sigala, Diamantis I. Tsilimigras, Stefan Knapp, Fredy Delgado Lagos, Ralf P. Brandes, Ilka Wittig, Maria Kyriaki Drekolia
Publikováno v:
Circulation. 143:935-948
Background: In vascular endothelial cells, cysteine metabolism by the cystathionine γ lyase (CSE), generates hydrogen sulfide–related sulfane sulfur compounds (H 2 S n ), that exert their biological actions via cysteine S -sulfhydration of target
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::45fbc368eaf9af958ab0a083e4851697
https://doi.org/10.1161/circulationaha.120.051877
https://doi.org/10.1161/circulationaha.120.051877
Myeloid-Specific Deletion of the AMPKα2 Subunit Alters Monocyte Protein Expression and Atherogenesis
Autor:
Beate Fisslthaler, Nina Zippel, Randa Abdel Malik, Fredy Delgado Lagos, Sven Zukunft, Janina Thoele, Daniel Siuda, Oliver Soehnlein, Ilka Wittig, Juliana Heidler, Andreas Weigert, Ingrid Fleming
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 12, p 3005 (2019)
The AMP-activated protein kinase (AMPK) is an energy sensing kinase that is activated by a drop in cellular ATP levels. Although several studies have addressed the role of the AMPKα1 subunit in monocytes and macrophages, little is known about the α
Externí odkaz:
https://doaj.org/article/4663e5abc50b481b9a102b9411365e32
Autor:
Fleming, Ürün Ukan, Fredy Delgado Lagos, Sebastian Kempf, Stefan Günther, Mauro Siragusa, Beate Fisslthaler, Ingrid
Publikováno v:
Cells; Volume 11; Issue 10; Pages: 1718
Macrophages are plastic and heterogeneous immune cells that adapt pro- or anti-inflammatory phenotypes upon exposure to different stimuli. Even though there has been evidence supporting a crosstalk between coagulation and innate immunity, the way in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=multidiscipl::06b3ae1e5ada8329c6ff561b66d68ef9
Autor:
Nina Zippel, Annemarieke E. Loot, Heike Stingl, Voahanginirina Randriamboavonjy, Ingrid Fleming, Beate Fisslthaler
Publikováno v:
International Journal of Molecular Sciences, Vol 19, Iss 9, p 2753 (2018)
AMP-activated protein kinase (AMPK) is frequently reported to phosphorylate Ser1177 of the endothelial nitric-oxide synthase (eNOS), and therefore, is linked with a relaxing effect. However, previous studies failed to consistently demonstrate a major
Externí odkaz:
https://doaj.org/article/ff9013c552e94fd69791b3f93505ffc6