Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Beate D. Quednau"'
Autor:
Dirk Nagorsen, Andreas Wolf, Scheele Juergen, Peter Kufer, Martin Libicher, Max S. Topp, Andreas Viardot, Richard Noppeney, Hermann Einsele, Stefan Kallert, Andreas Mackensen, Kathrin Rupertus, Margit Schmidt, Stefan Knop, Brigitte Dorsch, Ralf C. Bargou, Georg Hess, Eugen Leo, Patrick A. Baeuerle, Beate D. Quednau, Matthias Klinger, Gerhard Zugmaier, Maria-Elisabeth Goebeler, Lothar Kanz
Purpose Blinatumomab is a CD19/CD3 BiTE (bispecific T-cell engager) antibody construct for the treatment of Philadelphia chromosome–negative acute B-lymphoblastic leukemia. We evaluated blinatumomab in relapsed/refractory B-cell non-Hodgkin lymphom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9bfe83eb1a21601907fb5b98f2394e0
https://www.ncbi.nlm.nih.gov/pubmed/26884582
https://www.ncbi.nlm.nih.gov/pubmed/26884582
Autor:
Michela Ottolia, Kenneth D. Philipson, Hannes Reuter, Scott A. John, Beate D. Quednau, Zhiyong Qiu, Debora A. Nicoll
Publikováno v:
Annals of the New York Academy of Sciences. 976:1-10
An overview of the molecular physiology of the Na(+)/Ca(2+) exchanger is presented. This includes information on the variety of exchangers that have been described and their regulatory properties. Molecular insight is most detailed for the cardiac Na
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51ed47cbcfdec07e0c9521da10860163
https://doi.org/10.1111/j.1749-6632.2002.tb04708.x
https://doi.org/10.1111/j.1749-6632.2002.tb04708.x
Publikováno v:
Pfl�gers Archiv European Journal of Physiology. 447:543-548
The Na(+)/Ca(2+) exchanger gene family encompasses three distinct proteins, NCX1, NCX2, and NCX3, which mediate cellular Ca(2+) efflux and thus contribute to intracellular Ca(2+) homeostasis. NCX1 is expressed ubiquitously while NCX2 and NCX3 are lim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13b81452a0fc797fec3f05fb211d73b4
https://doi.org/10.1007/s00424-003-1065-4
https://doi.org/10.1007/s00424-003-1065-4
Autor:
Alexander Kraev, Beate D. Quednau, Stephen Leach, Xiao-Fang Li, Hui Dong, Robert Winkfein, Marco Perizzolo, Xinjiang Cai, RuoMei Yang, Kenneth D. Philipson, Jonathan Lytton
Publikováno v:
Journal of Biological Chemistry. 276:23161-23172
We describe here the identification and characterization of a novel member of the family of K(+)-dependent Na(+)/Ca(2+) exchangers, NCKX3 (gene SLC24A3). Human NCKX3 encodes a protein of 644 amino acids that displayed a high level of sequence identit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::410dcf9023890a49074b3baf67c25bf8
https://doi.org/10.1074/jbc.m102314200
https://doi.org/10.1074/jbc.m102314200
Autor:
Beate D. Quednau, Alexander Omelchenko, Mark Hnatowich, Larry V. Hryshko, Chris Dyck, Chadwick L. Elias, Kenneth D. Philipson
Publikováno v:
The Journal of General Physiology
Ion transport and regulation of Na(+)-Ca(2+) exchange were examined for two alternatively spliced isoforms of the canine cardiac Na(+)-Ca(2+) exchanger, NCX1.1, to assess the role(s) of the mutually exclusive A and B exons. The exchangers examined, N
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::930ca3e11bd85d3b6ac809e02013203b
https://doi.org/10.1085/jgp.114.5.701
https://doi.org/10.1085/jgp.114.5.701
Publikováno v:
American Journal of Physiology-Cell Physiology. 272:C1250-C1261
The gene coding for the Na+/Ca2+ exchanger NCX1 is characterized by a cluster of six exons (A, B, C, D, E, and F) coding for a variable region in the COOH terminus of the large intracellular loop of the protein. Alternative splicing of these exons ge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::658da23683d32ca84e3738c4978a16ba
https://doi.org/10.1152/ajpcell.1997.272.4.c1250
https://doi.org/10.1152/ajpcell.1997.272.4.c1250
Autor:
Kenneth D. Philipson, Beate D. Quednau, Aldons J. Lusis, Yu-Rong Xia, Debora A. Nicoll, Zhiyong Qui
Publikováno v:
Journal of Biological Chemistry. 271:24914-24921
NCX3 is the third isoform of a mammalian Na+-Ca2+ exchanger to be cloned. NCX3 was identified from rat brain cDNA by polymerase chain reaction (PCR) using degenerate primers derived from the sequences of two conserved regions of NCX1 and NCX2. The NC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2da0efdac2333d69b153397965d1a0fc
https://doi.org/10.1074/jbc.271.40.24914
https://doi.org/10.1074/jbc.271.40.24914
Autor:
Robert S. Ross, Beate D. Quednau, Kenneth D. Philipson, Maria C. Jordan, Susanne B. Nicholas, Kenneth P. Roos
Publikováno v:
Annals of the New York Academy of Sciences. 976
The cardiac-specific sodium-calcium exchanger (NCX1) is a GATA-4 dependent gene that is upregulated during cardiac hypertrophy and heart failure. To date, lack of an appropriate inhibitor of NCX1 and embryonic lethality of NCX1 knockout mice have slo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33d08196edf54803803b75254d685c6b
https://pubmed.ncbi.nlm.nih.gov/12502568
https://pubmed.ncbi.nlm.nih.gov/12502568
Publikováno v:
The Journal of General Physiology
We have cloned the squid neuronal Na+-Ca2+ exchanger, NCX-SQ1, expressed it in Xenopus oocytes, and characterized its regulatory and ion transport properties in giant excised membrane patches. The squid exchanger shows 58% identity with the canine Na
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::251362b498793f15cb9a62dabb038bc7
https://pubmed.ncbi.nlm.nih.gov/9607941
https://pubmed.ncbi.nlm.nih.gov/9607941
Autor:
Robert J. Winkfein, Marco Perizzolo, Xinjiang Cai, RuoMei Yang, Kenneth D. Philipson, Beate D. Quednau, Stephen Leach, Jonathan Lytton, Alexander Kraev, Xiao-Fang Li, Hui Dong
Publikováno v:
Journal of Biological Chemistry. 281:8996
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e61ede21545871d0119f465b27e885e2
https://doi.org/10.1016/s0021-9258(19)56605-4
https://doi.org/10.1016/s0021-9258(19)56605-4