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Optimization of a Nucleophilic Two-Step Radiosynthesis of 6-O-(2-[18F]fluoroethyl)-6-O-desmethyl-diprenorphine ([18F]FE-DPN) for PET Imaging of Brain Opioid Receptors

Autor: Enikő Németh, Barbara Gyuricza, Viktória Forgács, Paul Cumming, Gjermund Henriksen, János Marton, Beate Bauer, Pál Mikecz, Anikó Fekete

Publikováno v: International Journal of Molecular Sciences, Vol 24, Iss 17, p 13152 (2023)

We have established a method for nucleophilic one-pot, two-step radiosynthesis of the popular opioid receptor radioligand 6-O-(2-[18F]fluoroethyl)-6-O-desmethyl-diprenorphine ([18F]FE-DPN) from the novel precursor 6-O-(2-tosyloxyethyl)-6-O-desmethyl-

Externí odkaz: https://doaj.org/article/c1fcf105ced7449f8eeb5624b84f7ae9

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A New Precursor for the Radiosynthesis of 6-O-(2-[18F]Fluoroethyl)-6-Odesmethyl- diprenorphine ([18F]FE-DPN) by Nucleophilic Radiofluorination

Autor: Gjermund Henriksen, János Marton, Beate Bauer, Paul Cumming

Publikováno v: Letters in Organic Chemistry. 18:344-352

We present the preparation of the new precursor 6-O-(2-tosyloxyethoxy)-6-O-desmethyl-3- O-trityl-diprenorphine (TE-TDDPN) for a one-pot, two-step nucleophilic radiosynthesis of 6-O-(2- [18F]fluoroethyl-6-O-desmethyl-diprenorphine ([18F]FE-DPN). The r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6673995869cccdfba56583cac9568847
https://doi.org/10.2174/1570178617999200719153812

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