Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Beate Böhm"'
Publikováno v:
Cells, Vol 10, Iss 10, p 2705 (2021)
Mechanotransduction is elicited in cells upon the perception of physical forces transmitted via the extracellular matrix in their surroundings and results in signaling events that impact cellular functions. This physiological process is a prerequisit
Externí odkaz:
https://doaj.org/article/32551a725539451db7555ab925605a08
Publikováno v:
Rheumatology. 62:850-860
Objective To analyse pro-survival mechanisms elicited in RA synovial fibroblasts (RASFs) upon detachment from their extracellular matrix dependent on the disintegrin metalloproteinase ADAM15 and Yes-associated protein kinase 1 (YAP1). Methods Detachm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eda70a1f3c799156fb55973ed006ef83
https://doi.org/10.1093/rheumatology/keac354
https://doi.org/10.1093/rheumatology/keac354
Autor:
Stefan Haskamp, Steffen Uebe, Rotraut Mößner, Joseph Simon Horowitz, Beate Böhm, Sascha Gerdes, André Reis, Frank Behrens, Knut Schäkel, Gunter Assmann, Vinzenz Oji, Dagmar Wilsmann-Theis, Jörg C. Prinz, Sarah Schuhmann, Sandra Philipp, Kirsten Morrison, Harald Burkhardt, Ulrike Hüffmeier, Volker Schuster, Ansgar Weyergraf, Michael Sticherling, David Simon, Jürgen Rech, Ali Nimeh, Georg Schett, Arnd Jacobi, M. Köhm
Publikováno v:
Journal of Investigative Dermatology. 141:2079-2083
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc2257f769025ad72c558b47164d67e7
https://doi.org/10.1016/j.jid.2021.01.017
https://doi.org/10.1016/j.jid.2021.01.017
Autor:
Tatjana Scholz, Andreas Weigert, Bernhard Brüne, Christian D Sadik, Beate Böhm, Harald Burkhardt
Publikováno v:
PLoS ONE, Vol 12, Iss 8, p e0182646 (2017)
Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a pleiotropic, Th17-derived cytokine thought to critically contribute to the pathogenesis of diverse autoimmune diseases, including rheumatoid arthritis and psoriasis. Treatment with monocl
Externí odkaz:
https://doaj.org/article/bf00bc9928cb4bf98d6a88c7579b561e
Publikováno v:
PLoS ONE, Vol 13, Iss 9, p e0203847 (2018)
PLoS ONE
PLoS ONE
The regulation of temporo-spatial compartmentalization of protein synthesis is of crucial importance for a variety of physiologic cellular functions. Here, we demonstrate that the cell membrane-anchored disintegrin metalloproteinase ADAM15, upregulat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7efcd7ccf297c50b9cdda49392a6047b
http://europepmc.org/articles/PMC6161846?pdf=render
http://europepmc.org/articles/PMC6161846?pdf=render
Autor:
Harald Burkhardt, Raimund W. Kinne, Beate Böhm, Yuliya Fehrl, Pangrazio DeGiacomo, Tomasz Janczi
Publikováno v:
Arthritisrheumatology (Hoboken, N.J.). 71(1)
Objective To investigate mechanisms underlying the capability of ADAM15 to transform FasL-mediated death-inducing signals into prosurvival activation of Src and focal adhesion kinase (FAK) in rheumatoid arthritis synovial fibroblasts (RASFs). Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01cdae633596f289d04e232127969274
https://pubmed.ncbi.nlm.nih.gov/30003689
https://pubmed.ncbi.nlm.nih.gov/30003689
Autor:
André Reis, Harald Burkhardt, M. Köhm, Vinzenz Oji, Heiko Traupe, Ulrike Hüffmeier, Steffen Uebe, Sabine Löhr, Frank Behrens, Beate Böhm
Publikováno v:
British Journal of Dermatology. 175:639-641
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5ade74da868f0794d684e16bae7d204
https://doi.org/10.1111/bjd.14624
https://doi.org/10.1111/bjd.14624
Publikováno v:
Arthritis & Rheumatism. 65:2826-2834
Objective To study the contribution of ADAM15, a disintegrin metalloproteinase that is up-regulated in the rheumatoid arthritis (RA) synovial membrane, to the characteristic resistance of RA synovial fibroblasts (RASFs) to apoptosis induction by geno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9d9bf2fc268b7785f5244067dfe06ab1
https://doi.org/10.1002/art.38109
https://doi.org/10.1002/art.38109
Autor:
Steffen, Uebe, Maria, Ehrlicher, Arif Bülent, Ekici, Frank, Behrens, Beate, Böhm, Georg, Homuth, Claudia, Schurmann, Uwe, Völker, Michael, Jünger, Matthias, Nauck, Henry, Völzke, Heiko, Traupe, Michael, Krawczak, Harald, Burkhardt, André, Reis, Ulrike, Hüffmeier
Publikováno v:
BMC Medical Genetics
Background Psoriatic Arthritis (PsA) is a chronic inflammatory disease of the joints. PsA is etiologically complex, and 11 susceptibility loci have been identified so far. Most of these overlap with loci associated with psoriasis vulgaris (PsV), the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3a5ed5f3cc147140bea4e8974a958a40
https://pubmed.ncbi.nlm.nih.gov/28835222
https://pubmed.ncbi.nlm.nih.gov/28835222
Publikováno v:
Journal of Biological Chemistry. 287:21214-21223
ADAM15, a disintegrin and metalloproteinase, is capable of counteracting genotoxic stress-induced apoptosis by the suppression of caspase-3 activation. A cell line expressing the membrane-bound ADAM15 without its cytoplasmic tail, however, lost this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::938f6c276d8f2d16e16e3845b5e1ece9
https://doi.org/10.1074/jbc.m112.347120
https://doi.org/10.1074/jbc.m112.347120