Zobrazeno 1 - 10
of 328
pro vyhledávání: '"Beate, Winner"'
Autor:
Sebastian Schmidt, Constantin Stautner, Duc Tung Vu, Alexander Heinz, Martin Regensburger, Ozge Karayel, Dietrich Trümbach, Anna Artati, Sabine Kaltenhäuser, Mohamed Zakaria Nassef, Sina Hembach, Letyfee Steinert, Beate Winner, Winkler Jürgen, Martin Jastroch, Malte D. Luecken, Fabian J. Theis, Gil Gregor Westmeyer, Jerzy Adamski, Matthias Mann, Karsten Hiller, Florian Giesert, Daniela M. Vogt Weisenhorn, Wolfgang Wurst
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-24 (2023)
Abstract Sporadic Parkinson’s Disease (sPD) is a progressive neurodegenerative disorder caused by multiple genetic and environmental factors. Mitochondrial dysfunction is one contributing factor, but its role at different stages of disease progress
Externí odkaz:
https://doaj.org/article/221c463f9fd24a92948d727c0c8d5a38
Autor:
Florian Krach, Judith Stemick, Tom Boerstler, Alexander Weiss, Ioannis Lingos, Stephanie Reischl, Holger Meixner, Sonja Ploetz, Michaela Farrell, Ute Hehr, Zacharias Kohl, Beate Winner, Juergen Winkler
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Krach et al. dissect the molecular mechanism of the alternative splicing modulator Branaplam in Huntington’s disease. They show that the drug lowers mutant HTT protein levels and ameliorates alternative splicing pathology in an iPSC disease model.
Externí odkaz:
https://doaj.org/article/de498125578b4e53ac4080e1dc3242e6
Autor:
Mark van den Hurk, Shong Lau, Maria C. Marchetto, Jerome Mertens, Shani Stern, Olga Corti, Alexis Brice, Beate Winner, Jürgen Winkler, Fred H. Gage, Cedric Bardy
Publikováno v:
npj Parkinson's Disease, Vol 8, Iss 1, Pp 1-18 (2022)
Abstract Complex genetic predispositions accelerate the chronic degeneration of midbrain substantia nigra neurons in Parkinson’s disease (PD). Deciphering the human molecular makeup of PD pathophysiology can guide the discovery of therapeutics to s
Externí odkaz:
https://doaj.org/article/14683e153a4e4a20901fa0656fbb2213
Autor:
Sebastian Schmidt, Malte D. Luecken, Dietrich Trümbach, Sina Hembach, Kristina M. Niedermeier, Nicole Wenck, Klaus Pflügler, Constantin Stautner, Anika Böttcher, Heiko Lickert, Ciro Ramirez-Suastegui, Ruhel Ahmad, Michael J. Ziller, Julia C. Fitzgerald, Viktoria Ruf, Wilma D. J. van de Berg, Allert J. Jonker, Thomas Gasser, Beate Winner, Jürgen Winkler, Daniela M. Vogt Weisenhorn, Florian Giesert, Fabian J. Theis, Wolfgang Wurst
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-25 (2022)
Here, the authors reveal using single-cell RNA sequencing that Parkinson’s disease (PD) patient-derived neuronal cells show altered primary cilia morphology and signaling suggesting cilia dysfunction may underlie PD pathogenesis.
Externí odkaz:
https://doaj.org/article/b648848b74c14840be9be48f8be10660
Autor:
Shani Stern, Shong Lau, Andreea Manole, Idan Rosh, Menachem Mendel Percia, Ran Ben Ezer, Maxim N. Shokhirev, Fan Qiu, Simon Schafer, Abed AlFatah Mansour, Kile P. Mangan, Tchelet Stern, Polina Ofer, Yam Stern, Ana Paula Diniz Mendes, Jose Djamus, Lynne Randolph Moore, Ritu Nayak, Sapir Havusha Laufer, Aidan Aicher, Amanda Rhee, Thomas L. Wong, Thao Nguyen, Sara B. Linker, Beate Winner, Beatriz C. Freitas, Eugenia Jones, Irit Sagi, Cedric Bardy, Alexis Brice, Juergen Winkler, Maria C. Marchetto, Fred H. Gage
Publikováno v:
npj Parkinson's Disease, Vol 8, Iss 1, Pp 1-16 (2022)
Abstract Several mutations that cause Parkinson’s disease (PD) have been identified over the past decade. These account for 15–25% of PD cases; the rest of the cases are considered sporadic. Currently, it is accepted that PD is not a single monol
Externí odkaz:
https://doaj.org/article/2fa050a5687248eaa0da9d23e96a5eb4
Autor:
Enes Yağız Akdaş, Soeren Turan, Debarpan Guhathakurta, Arif Ekici, Seda Salar, D. Chichung Lie, Beate Winner, Anna Fejtova
Publikováno v:
Stem Cell Research, Vol 67, Iss , Pp 103012- (2023)
C-terminal Binding Protein 1 (CTBP1) is a ubiquitously expressed transcriptional co-repressor and membrane trafficking regulator. A recurrent de novo c.991C>T mutation in CTBP1 leads to expression of p.R331W CTBP1 and causes hypotonia, ataxia, develo
Externí odkaz:
https://doaj.org/article/037bb49e8afb41ffb0d59ffa05ab178f
Autor:
Iris Stolzer, Eveline Scherer, Patrick Süß, Veit Rothhammer, Beate Winner, Markus F. Neurath, Claudia Günther
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 19, p 14925 (2023)
The gut microbiome plays a pivotal role in maintaining human health, with numerous studies demonstrating that alterations in microbial compositions can significantly affect the development and progression of various immune-mediated diseases affecting
Externí odkaz:
https://doaj.org/article/e07716ca4c9f48d787f6927adf93a177
Autor:
Frank K. Braun, Tanja Rothhammer-Hampl, Julia Lorenz, Sandra Pohl, Ayse-Nur Menevse, Arabel Vollmann-Zwerenz, Elisabeth Bumes, Maren Büttner, Saida Zoubaa, Martin Proescholdt, Nils O. Schmidt, Peter Hau, Philipp Beckhove, Beate Winner, Markus J. Riemenschneider
Publikováno v:
Cells, Vol 12, Iss 14, p 1856 (2023)
Conventional 2D cultures are commonly used in cancer research though they come with limitations such as the lack of microenvironment or reduced cell heterogeneity. In this study, we investigated in what respect a scaffold-based (Matrigel™) 3D cultu
Externí odkaz:
https://doaj.org/article/34a1a8f1e65a4f44afca380bf5cfda63
Autor:
Lukas Leupold, Veronika Sigutova, Elizaveta Gerasimova, Martin Regensburger, Sebastian Zundler, Friederike Zunke, Wei Xiang, Beate Winner, Iryna Prots
Publikováno v:
Frontiers in Neurology, Vol 13 (2022)
The accumulation of alpha-synuclein (aSyn) is the hallmark of a group of neurodegenerative conditions termed synucleopathies. Physiological functions of aSyn, including those outside of the CNS, remain elusive. However, a reliable and reproducible ev
Externí odkaz:
https://doaj.org/article/5d546d818a5549c594c9efc5d1d12f4a
Autor:
Leonie Wittner, Lukas Wagener, Jakob J. Wiese, Iris Stolzer, Susanne M. Krug, Elisabeth Naschberger, Rene Jackstadt, Rudi Beyaert, Raja Atreya, Anja A. Kühl, Gregor Sturm, Miguel Gonzalez-Acera, Jay V. Patankar, Christoph Becker, Britta Siegmund, Zlatko Trajanoski, Beate Winner, Markus F. Neurath, Michael Schumann, Claudia Günther
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 8, p 7402 (2023)
The paracaspase MALT1 is a crucial regulator of immune responses in various cellular contexts. Recently, there is increasing evidence suggesting that MALT1 might represent a novel key player in mucosal inflammation. However, the molecular mechanisms
Externí odkaz:
https://doaj.org/article/f577382e6af3416e99287fc343607f9e