Zobrazeno 1 - 10
of 117
pro vyhledávání: '"Beate, Sodeik"'
Autor:
Guorong Sun, Kai Alexander Kropp, Marieluise Kirchner, Nina Plückebaum, Anton Selich, Manutea Serrero, Akshay Dhingra, Jorge Rubén Cabrera, Birgit Ritter, Rudolf Bauerfeind, Emanuel Wyler, Markus Landthaler, Axel Schambach, Beate Sodeik, Philipp Mertins, Abel Viejo-Borbolla
Publikováno v:
mBio, Vol 15, Iss 2 (2024)
ABSTRACT The highly prevalent herpes simplex virus type 1 (HSV-1) causes a range of diseases, including cold sores, blinding keratitis, and life-threatening encephalitis. HSV-1 initially replicates in epithelial cells, enters the peripheral nervous s
Externí odkaz:
https://doaj.org/article/b03f18e16aa44eca859b26cb7c0b5163
Autor:
Manutea C Serrero, Virginie Girault, Sebastian Weigang, Todd M Greco, Ana Ramos-Nascimento, Fenja Anderson, Antonio Piras, Ana Hickford Martinez, Jonny Hertzog, Anne Binz, Anja Pohlmann, Ute Prank, Jan Rehwinkel, Rudolf Bauerfeind, Ileana M Cristea, Andreas Pichlmair, Georg Kochs, Beate Sodeik
Publikováno v:
eLife, Vol 11 (2022)
Host proteins sense viral products and induce defence mechanisms, particularly in immune cells. Using cell-free assays and quantitative mass spectrometry, we determined the interactome of capsid-host protein complexes of herpes simplex virus and iden
Externí odkaz:
https://doaj.org/article/b040d0b00f5e4a9dbd3a033d775dd1a5
Autor:
Judith Lang, Patrick Bohn, Hilal Bhat, Holger Jastrow, Bernd Walkenfort, Feyza Cansiz, Julian Fink, Michael Bauer, Dominik Olszewski, Ana Ramos-Nascimento, Vikas Duhan, Sarah-Kim Friedrich, Katrin Anne Becker, Adalbert Krawczyk, Michael J. Edwards, Andreas Burchert, Magdalena Huber, Justa Friebus-Kardash, Joachim R. Göthert, Cornelia Hardt, Hans Christian Probst, Fabian Schumacher, Karl Köhrer, Burkhard Kleuser, Eduard B. Babiychuk, Beate Sodeik, Jürgen Seibel, Urs F. Greber, Philipp A. Lang, Erich Gulbins, Karl S. Lang
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Macrophages are critical in limiting replication of herpes simplex virus type 1 (HSV-1). Here the authors show how acid ceramidase and its enzymatic product sphingosine enable multivesicular bodies to function as an anti-viral mechanism.
Externí odkaz:
https://doaj.org/article/ce87beeac86246829e4b47c4ed971f39
Autor:
Niko Hensel, Verena Raker, Benjamin Förthmann, Nora Tula Detering, Sabrina Kubinski, Anna Buch, Georgios Katzilieris-Petras, Julia Spanier, Viktoria Gudi, Sylvia Wagenknecht, Verena Kopfnagel, Thomas Andreas Werfel, Martin Stangel, Andreas Beineke, Ulrich Kalinke, Søren Riis Paludan, Beate Sodeik, Peter Claus
Publikováno v:
Journal of Neuroinflammation, Vol 16, Iss 1, Pp 1-15 (2019)
Abstract Background Herpes simplex virus-1 (HSV-1) infections of the central nervous system (CNS) can result in HSV-1 encephalitis (HSE) which is characterized by severe brain damage and long-term disabilities. Different cell types including neurons
Externí odkaz:
https://doaj.org/article/6e9d92d914bf4354b8b0dd0af8a1ce9c
Autor:
Vesa Aho, Sami Salminen, Salla Mattola, Alka Gupta, Felix Flomm, Beate Sodeik, Jens B Bosse, Maija Vihinen-Ranta
Publikováno v:
PLoS Pathogens, Vol 17, Iss 12, p e1010132 (2021)
Herpes simplex virus capsids are assembled and packaged in the nucleus and move by diffusion through the nucleoplasm to the nuclear envelope for egress. Analyzing their motion provides conclusions not only on capsid transport but also on the properti
Externí odkaz:
https://doaj.org/article/c690cb1cb8fd4051bd72d5ee40577eb2
Autor:
Peter Naniima, Eleonora Naimo, Sandra Koch, Ute Curth, Khaled R. Alkharsah, Luisa J. Ströh, Anne Binz, Jan-Marc Beneke, Benjamin Vollmer, Heike Böning, Eva Maria Borst, Prashant Desai, Jens Bohne, Martin Messerle, Rudolf Bauerfeind, Pierre Legrand, Beate Sodeik, Thomas F. Schulz, Thomas Krey
Publikováno v:
PLoS Biology, Vol 19, Iss 11 (2021)
Herpesviruses cause severe diseases particularly in immunocompromised patients. Both genome packaging and release from the capsid require a unique portal channel occupying one of the 12 capsid vertices. Here, we report the 2.6 Å crystal structure of
Externí odkaz:
https://doaj.org/article/5baa5853f4194387a43957495e2d295d
Autor:
Niko Hensel, Verena Raker, Benjamin Förthmann, Anna Buch, Beate Sodeik, Andreas Pich, Peter Claus
Publikováno v:
Frontiers in Neurology, Vol 11 (2020)
Infections of the brain with herpes simplex virus type 1 (HSV-1) cause life-threatening Herpes simplex encephalitis (HSE) characterized by viral replication in neurons and neuro-inflammation including an infiltration of peripheral immune cells. HSV-1
Externí odkaz:
https://doaj.org/article/4ca3f12285284995a71803bd15aaab63
Autor:
Linda Grosche, Katinka Döhner, Alexandra Düthorn, Ana Hickford-Martinez, Alexander Steinkasserer, Beate Sodeik
Publikováno v:
Bio-Protocol, Vol 9, Iss 23 (2019)
Given the endemic seroprevalence of herpes simplex viruses (HSV), its associated human diseases, and the emergence of acyclovir-resistant strains, there is a continuous need for better antiviral therapies. Towards this aim, identifying mechanistic de
Externí odkaz:
https://doaj.org/article/175faf5fd78643d399703d7314031fb9
Autor:
Vesa Aho, Elina Mäntylä, Axel Ekman, Satu Hakanen, Salla Mattola, Jian-Hua Chen, Venera Weinhardt, Visa Ruokolainen, Beate Sodeik, Carolyn Larabell, Maija Vihinen-Ranta
Publikováno v:
Viruses, Vol 11, Iss 10, p 935 (2019)
During lytic herpes simplex virus 1 (HSV-1) infection, the expansion of the viral replication compartments leads to an enrichment of the host chromatin in the peripheral nucleoplasm. We have shown previously that HSV-1 infection induces the formation
Externí odkaz:
https://doaj.org/article/520d04d11c93468c8523680608e82d5d
Autor:
Katinka Döhner, Ana Ramos-Nascimento, Dagmara Bialy, Fenja Anderson, Ana Hickford-Martinez, Franziska Rother, Thalea Koithan, Kathrin Rudolph, Anna Buch, Ute Prank, Anne Binz, Stefanie Hügel, Robert Jan Lebbink, Rob C Hoeben, Enno Hartmann, Michael Bader, Rudolf Bauerfeind, Beate Sodeik
Publikováno v:
PLoS Pathogens, Vol 14, Iss 1, p e1006823 (2018)
Herpesviruses are large DNA viruses which depend on many nuclear functions, and therefore on host transport factors to ensure specific nuclear import of viral and host components. While some import cargoes bind directly to certain transport factors,
Externí odkaz:
https://doaj.org/article/a57692e99186492db7bba0af26e5ad8d