Zobrazeno 1 - 10
of 73
pro vyhledávání: '"Beata Wojciak-Stothard"'
Autor:
Alexander J. Ainscough, Timothy J. Smith, Maike Haensel, Christopher J. Rhodes, Adam Fellows, Harry J. Whitwell, Eleni Vasilaki, Kelly Gray, Adrian Freeman, Luke S. Howard, John Wharton, Benjamin Dunmore, Paul D. Upton, Martin R. Wilkins, Joshua B. Edel, Beata Wojciak-Stothard
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-15 (2022)
A biomimetic inducible model of pulmonary arterial hypertension (PAH) is presented, combining natural and induced BMPR2 dysfunction with hypoxia in lung endothelial cells and blood-derived PAH cells to induce smooth muscle activation & proliferation.
Externí odkaz:
https://doaj.org/article/23b65781f0864f158a058def624a88d9
Autor:
Giusy Russomanno, Kyeong Beom Jo, Vahitha B. Abdul-Salam, Claire Morgan, Jens Endruschat, Ute Schaeper, Ahmed H. Osman, Mai M. Alzaydi, Martin R. Wilkins, Beata Wojciak-Stothard
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 23, Iss , Pp 142-153 (2021)
Circulating levels of endothelial miR-150 are reduced in pulmonary arterial hypertension (PAH) and act as an independent predictor of patient survival, but links between endothelial miR-150 and vascular dysfunction are not well understood. We studied
Externí odkaz:
https://doaj.org/article/1ef7e3ae6a3743cb92c264e332ebbdb8
Publikováno v:
SciMedicine Journal, Vol 2, Iss 4, Pp 243-271 (2020)
Pulmonary Hypertension (PH) is a multifactorial and lethal disease, characterised by elevated pulmonary arterial pressure and progressive right heart failure. PH pathobiology rests on four pillars: vascular remodelling, vasoconstriction, inflammation
Externí odkaz:
https://doaj.org/article/1947abdefbae4904b9184e9241d09a70
Autor:
Hebah A. Sindi, Giusy Russomanno, Sandro Satta, Vahitha B. Abdul-Salam, Kyeong Beom Jo, Basma Qazi-Chaudhry, Alexander J. Ainscough, Robert Szulcek, Harm Jan Bogaard, Claire C. Morgan, Soni S. Pullamsetti, Mai M. Alzaydi, Christopher J. Rhodes, Roberto Piva, Christina A. Eichstaedt, Ekkehard Grünig, Martin R. Wilkins, Beata Wojciak-Stothard
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Pulmonary arterial hypertension is a severe lung disease characterised by progressive vascular remodelling. Here, the authors show that reduced signalling of flow-activated transcription factor KLF2 is a common feature of human PAH and that KLF2-regu
Externí odkaz:
https://doaj.org/article/4eebb969beec4b25a1d7906be6c74e47
Autor:
Hebah A. Sindi, Giusy Russomanno, Sandro Satta, Vahitha B. Abdul-Salam, Kyeong Beom Jo, Basma Qazi-Chaudhry, Alexander J. Ainscough, Robert Szulcek, Harm Jan Bogaard, Claire C. Morgan, Soni S. Pullamsetti, Mai M. Alzaydi, Christopher J. Rhodes, Roberto Piva, Christina A. Eichstaedt, Ekkehard Grünig, Martin R. Wilkins, Beata Wojciak-Stothard
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-1 (2020)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Externí odkaz:
https://doaj.org/article/fa8a888d88b04f9885e436a2355e805e
Publikováno v:
PLoS ONE, Vol 5, Iss 1, p e8774 (2010)
Migrating leukocytes normally have a polarized morphology with an actin-rich lamellipodium at the front and a uropod at the rear. Microtubules (MTs) are required for persistent migration and chemotaxis, but how they affect cell polarity is not known.
Externí odkaz:
https://doaj.org/article/c6bea63751a044e9aa9b0da3bef0d2b0
Autor:
Maike Haensel, Beata Wojciak-Stothard
Publikováno v:
Current Opinion in Physiology. 34:100667
Autor:
Beata Wojciak-Stothard, Vahitha B. Abdul-Salam, Giuseppe Faggian, Michele Miragoli, Roman Y. Medvedev, Julia Gorelik, Anita Alvarez-Laviada, Jose L. Sanchez-Alonso, Eef Dries, Natalia A. Trayanova, Stefano Rossi, Tilo Schorn
Publikováno v:
Hypertension
Pulmonary hypertension is a complex disorder characterized by pulmonary vascular remodeling and right ventricular hypertrophy, leading to right heart failure. The mechanisms underlying this process are not well understood. We hypothesize that the str
Publikováno v:
SciMedicine Journal, Vol 2, Iss 4, Pp 243-271 (2020)
Pulmonary Hypertension (PH) is a multifactorial and lethal disease, characterised by elevated pulmonary arterial pressure and progressive right heart failure. PH pathobiology rests on four pillars: vascular remodelling, vasoconstriction, inflammation
Autor:
Jens Endruschat, Claire Morgan, Martin R. Wilkins, Ahmed H. Osman, Beata Wojciak-Stothard, Giusy Russomanno, Mai M. Alzaydi, Kyeong Beom Jo, Ute Schaeper, Vahitha B. Abdul-Salam
Publikováno v:
Molecular Therapy. Nucleic Acids
Molecular Therapy: Nucleic Acids, Vol 23, Iss, Pp 142-153 (2021)
MOLECULAR THERAPY-NUCLEIC ACIDS
Molecular Therapy: Nucleic Acids, Vol 23, Iss, Pp 142-153 (2021)
MOLECULAR THERAPY-NUCLEIC ACIDS
Circulating levels of endothelial miR-150 are reduced in pulmonary arterial hypertension (PAH) and act as an independent predictor of patient survival, but links between endothelial miR-150 and vascular dysfunction are not well understood. We studied