Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Beata Naumczuk"'
Publikováno v:
Molecules, Vol 29, Iss 17, p 4122 (2024)
Because of their topical application in patients and meaningful UV/VIS absorptive properties, the degradation and potential toxicity under irradiation of diflunisal (DIF) and naphazoline (NAF) were studied. In addition, the impact of pH on their phot
Externí odkaz:
https://doaj.org/article/5a8c9f39b256445bb426ff1783068252
Publikováno v:
Pharmaceuticals, Vol 17, Iss 1, p 98 (2024)
Timolol (TIM) is a non-selective ß-adrenergic receptor antagonist used orally for the treatment of hypertension and heart attacks, and topically for treating glaucoma; lately, it has also been used in some specific dermatological problems. In the pr
Externí odkaz:
https://doaj.org/article/d4898c2631e14d26be31f233e0838e61
Autor:
Wojciech Bocian, Beata Naumczuk, Magdalena Urbanowicz, Jerzy Sitkowski, Elżbieta Bednarek, Katarzyna Wiktorska, Anna Pogorzelska, Ewelina Wielgus, Lech Kozerski
Publikováno v:
Molecules, Vol 27, Iss 20, p 6946 (2022)
The understanding of the mechanism of Topo I inhibition by organic ligands is a crucial source of information that has led to the design of more effective and safe pharmaceuticals in oncological chemotherapy. The vast number of inhibitors that have b
Externí odkaz:
https://doaj.org/article/723e9304008a456483bf9f48a82cbe21
Autor:
Wojciech Bocian, Beata Naumczuk, Magdalena Urbanowicz, Jerzy Sitkowski, Anna Bierczyńska-Krzysik, Elżbieta Bednarek, Katarzyna Wiktorska, Małgorzata Milczarek, Lech Kozerski
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 14, p 7471 (2021)
The compounds 7-ethyl-9-(N-methylamino)methyl-10-hydroxycamptothecin (2) and 7-ethyl-9-(N-morpholino)methyl-10-hydroxycamptothecin (3) are potential topoisomerase I poisons. Moreover, they were shown to have favorable anti-neoplastic effects on sever
Externí odkaz:
https://doaj.org/article/333cfa843c6943e8844782d6f38eeb5b
Autor:
Elżbieta Bednarek, Wojciech Bocian, Magdalena Urbanowicz, Jerzy Sitkowski, Beata Naumczuk, Lech Kozerski
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 15, p 8190 (2021)
Novel nontoxic derivatives of SN38 with favorable antineoplastic properties were characterized in water solution using NMR. The phenomena observed by NMR were linked to basic pharmacological properties, such as solubility, bioavailability, chemical a
Externí odkaz:
https://doaj.org/article/6d46a4007a8544ba9c8efa1b9ba71131
Publikováno v:
Forensic Toxicology. 39:45-58
Purpose The number of new synthetic opioids, especially fentanyl analogs, on the illicit market is increasing each year and becoming a disturbing phenomenon. Due to the very high potency, ease of addiction and high risk of overdose with the fatal eff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2fd76fdba0ea8c7c1053c9911a5aca04
https://doi.org/10.1007/s11419-020-00539-6
https://doi.org/10.1007/s11419-020-00539-6
Publikováno v:
Magnetic Resonance in Chemistry. 58:191-197
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bbbc038b1c06c91a3cef732db2b4309
https://doi.org/10.1002/mrc.4963
https://doi.org/10.1002/mrc.4963
Autor:
Lech Kozerski, Robert Kawęcki, Elżbieta Bednarek, Jerzy Sitkowski, Wojciech Bocian, Beata Naumczuk
Publikováno v:
Journal of Molecular Structure. 1176:298-302
We present first evidence of a spontaneous alkylation of the 2′-deoxycytidine by potential topoisomerase I inhibitors from camptothecins family. The 7-ethyl-9-(N-morpholino)methyl-10-hydroxycamptothecin and the 7-ethyl-9-(N-pyrrolidinyl)methyl-10-h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ce4e77cfef771ca723f5aa4682c8f2ab
https://doi.org/10.1016/j.molstruc.2018.08.096
https://doi.org/10.1016/j.molstruc.2018.08.096
Publikováno v:
New Journal of Chemistry. 43:18975-18978
The mechanism of alkylation of the 2′-deoxyadenosine (dA) by potential topoisomerase I (Top I) inhibitors, from the camptothecin family, is described in water and in DMSO-d6. The products of the reactions depend on the solvent; however in both case
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::50841c207998e8f0e26b2fd87a86aada
https://doi.org/10.1039/c9nj04828f
https://doi.org/10.1039/c9nj04828f
Publikováno v:
Forensic toxicology. 40(1)
Purpose New psychoactive substances (NPSs) still appear on the market, mainly due to their legal status. This situation indicates and alarms that permanent recognition of the designer drug scene should be conducted. In this paper, we describe the det
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf44fb18d12757f42c159e937acf7fb6
https://pubmed.ncbi.nlm.nih.gov/36454490
https://pubmed.ncbi.nlm.nih.gov/36454490