Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Beata Labuzek"'
Autor:
Constantinos G. Neochoritis, Maryam Kazemi Miraki, Eman M. M. Abdelraheem, Ewa Surmiak, Tryfon Zarganes-Tzitzikas, Beata Łabuzek, Tad A. Holak, Alexander Dömling
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 15, Iss 1, Pp 513-520 (2019)
Macrocycles were designed to antagonize the protein–protein interaction p53-MDM2 based on the three-finger pharmacophore F19W23L25. The synthesis was accomplished by a rapid, one-pot synthesis of indole-based macrocycles based on Ugi macrocyclizati
Externí odkaz:
https://doaj.org/article/714269d16b8d497eab7b91bf23d416a7
Autor:
Florian Nietzold, Stefan Rubner, Beata Labuzek, Przemysław Golik, Ewa Surmiak, Xabier del Corte, Radoslaw Kitel, Christoph Protzel, Regina Reppich‐Sacher, Jan Stichel, Katarzyna Magiera‐Mularz, Tad A. Holak, Thorsten Berg
Publikováno v:
ChemBioChem. 24
Nutlin-3a is a reversible inhibitor of the p53/MDM2 interaction. We have synthesized the derivative Nutlin-3a-aa bearing an additional exocyclic methylene group in the piperazinone moiety. Nutlin-3a-aa is more active than Nutlin-3a against purified w
Autor:
Beata Labuzek, Ramon van der Vlag, Constantinos G. Neochoritis, Fatima Kassim, Aleksandra Twarda-Clapa, Anna K. H. Hirsch, Tommaso Felicetti, Cagdas Ermis, Bogdan Musielak, Alexander Dömling, M. Yagiz Unver, Tad A. Holak
Publikováno v:
Chemmedchem
ChemMedChem
United States
Germany
ChemMedChem, 15(4), 370-375. WILEY-V C H VERLAG GMBH
ChemMedChem
United States
Germany
ChemMedChem, 15(4), 370-375. WILEY-V C H VERLAG GMBH
Innovative and efficient hit‐identification techniques are required to accelerate drug discovery. Protein‐templated fragment ligations represent a promising strategy in early drug discovery, enabling the target to assemble and select its binders
Autor:
Tad A. Holak, Alexander Dömling, Ran Zhang, Constantinos G. Neochoritis, Daniel G. Rivera, Ewa Surmiak, Matthew Groves, Jacek Plewka, Lukasz Skalniak, Beata Labuzek, Ameena M Ali, Manuel G. Ricardo, Jack Atmaj
Publikováno v:
Angewandte Chemie (International ed. in English), 59(13), 5235-5241. WILEY-V C H VERLAG GMBH
Stapled peptides are chemical entities in-between biologics and small molecules, which have proven to be the solution to high affinity protein–protein interaction antagonism, while keeping control over pharmacological performance such as stability
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0769ba57d31d9c62f8a107a610f30806
https://research.rug.nl/en/publications/1eed797b-c10f-4401-9039-feefae3bb9b6
https://research.rug.nl/en/publications/1eed797b-c10f-4401-9039-feefae3bb9b6
Autor:
Beata Labuzek, Lukasz Skalniak, Tad A. Holak, Ameena M Ali, Aleksandra Twarda-Clapa, Grzegorz Dubin, Matthew Groves, Sylwia Krzanik, Constantinos G. Neochoritis, Ewa Surmiak, Monika Machula, Alexander Dömling, Aneta Wisniewska
Publikováno v:
The FEBS Journal, 286(7), 1360-1374. NLM (Medline)
The p53 protein is engaged in the repair of DNA mutations and elimination of heavily damaged cells, providing anti-cancer protection. Dysregulation of p53 activity is a crucial step in carcinogenesis. This dysregulation is often caused by the overexp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::860bf587fa3077f3ae7c510a989a23f3
https://research.rug.nl/en/publications/73613fa3-7146-4637-97c4-48ff108ada19
https://research.rug.nl/en/publications/73613fa3-7146-4637-97c4-48ff108ada19
Autor:
Aleksandra Twarda-Clapa, Beata Labuzek, Dobroslawa Krzemien, Tad A. Holak, Przemyslaw Grudnik, Bogdan Musielak, Grzegorz Dubin
Recent research has identified a potential role of the hyaluronic acid receptor stabilin-2 (Stab2) in cancer metastasis. Stab2 belongs to a group of scavenger receptors and is responsible for the clearance of more than ten ligands, including hyaluron
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d874d67a5a2a7b57e41d5f7f7042933a
https://ruj.uj.edu.pl/xmlui/handle/item/66244
https://ruj.uj.edu.pl/xmlui/handle/item/66244
Autor:
Alexander Dömling, Katarzyna Kubica, Beata Labuzek, Constantinos G. Neochoritis, Katarzyna Guzik, Lukasz Skalniak, Sylwia Krzanik, Kaja Kowalska, Kareem Khoury, Tad A. Holak, Aleksandra Twarda-Clapa, Grzegorz Dubin, Miroslawa Czub
Publikováno v:
Journal of Medicinal Chemistry, 60(10), 4234-4244. AMER CHEMICAL SOC
The tumor suppressor protein p53, the "guardian of the genome", is inactivated in nearly all cancer types by mutations in the TP53 gene or by overexpression of its negative regulators, oncoproteins MDM2/MDMX. Recovery of p53 function by disrupting th