Zobrazeno 1 - 10
of 85
pro vyhledávání: '"Beata Duszyńska"'
Autor:
Przemysław Zaręba, Anna K. Drabczyk, Artur Wnorowski, Maciej Maj, Katarzyna Malarz, Patryk Rurka, Gniewomir Latacz, Beata Duszyńska, Krzesimir Ciura, Katarzyna Ewa Greber, Anna Boguszewska-Czubara, Paweł Śliwa, Julia Kuliś
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 19, p 10287 (2024)
The serotonin 5-HT6 receptor (5-HT6R), expressed almost exclusively in the brain, affects the Cdk5 signaling as well as the mTOR pathway. Due to the association of 5-HT6R signaling with pathways involved in cancer progression, we decided to check the
Externí odkaz:
https://doaj.org/article/659b0b2212e84844abe3800c3fdad23d
Autor:
Anna Stankiewicz, Katarzyna Kaczorowska, Ryszard Bugno, Aneta Kozioł, Maria H. Paluchowska, Grzegorz Burnat, Barbara Chruścicka, Paulina Chorobik, Piotr Brański, Joanna M. Wierońska, Beata Duszyńska, Andrzej Pilc, Andrzej J. Bojarski
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 211-225 (2022)
Considering the allosteric regulation of mGlu receptors for potential therapeutic applications, we developed a group of 1,2,4-oxadiazole derivatives that displayed mGlu4 receptor positive allosteric modulatory activity (EC50 = 282–656 nM). Selectiv
Externí odkaz:
https://doaj.org/article/986c7044b75f497b83b535e2846fde7c
Autor:
Katarzyna Kaczorowska, Anna Stankiewicz, Ryszard Bugno, Maria H. Paluchowska, Grzegorz Burnat, Piotr Brański, Paulina Cieślik, Joanna M. Wierońska, Mariusz Milik, Mateusz Nowak, Agnieszka Przybyłowicz, Aneta Kozioł, Agata Hogendorf, Adam S. Hogendorf, Justyna Kalinowska-Tłuścik, Beata Duszyńska, Andrzej Pilc, Andrzej J. Bojarski
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 3, p 1981 (2023)
Following the glutamatergic theory of schizophrenia and based on our previous study regarding the antipsychotic-like activity of mGlu7 NAMs, we synthesized a new compound library containing 103 members, which were examined for NAM mGlu7 activity in t
Externí odkaz:
https://doaj.org/article/36b1ab318b594487bcb8fddbbc732485
Autor:
Agata Hogendorf, Adam S. Hogendorf, Rafał Kurczab, Grzegorz Satała, Bernadeta Szewczyk, Paulina Cieślik, Gniewomir Latacz, Jadwiga Handzlik, Tomasz Lenda, Katarzyna Kaczorowska, Jakub Staroń, Ryszard Bugno, Beata Duszyńska, Andrzej J. Bojarski
Publikováno v:
Molecules, Vol 26, Iss 15, p 4605 (2021)
A series of N-skatyltryptamines was synthesized and their affinities for serotonin and dopamine receptors were determined. Compounds exhibited activity toward 5-HT1A, 5-HT2A, 5-HT6, and D2 receptors. Substitution patterns resulting in affinity/activi
Externí odkaz:
https://doaj.org/article/161dfe1128284230be1a6f666c15721d
Autor:
Vittorio Canale, Magdalena Kotańska, Anna Dziubina, Matylda Stefaniak, Agata Siwek, Gabriela Starowicz, Krzysztof Marciniec, Patryk Kasza, Grzegorz Satała, Beata Duszyńska, Xavier Bantreil, Frédéric Lamaty, Marek Bednarski, Jacek Sapa, Paweł Zajdel
Publikováno v:
Molecules, Vol 26, Iss 13, p 3828 (2021)
The complex pathophysiology of depression, together with the limits of currently available antidepressants, has resulted in the continuous quest for alternative therapeutic strategies. Numerous findings suggest that pharmacological blockade of α2-ad
Externí odkaz:
https://doaj.org/article/3d558fc453414e93aad47bd1aa904ce4
Autor:
Marek Król, Grzegorz Ślifirski, Jerzy Kleps, Szymon Ulenberg, Mariusz Belka, Tomasz Bączek, Agata Siwek, Katarzyna Stachowicz, Bernadeta Szewczyk, Gabriel Nowak, Beata Duszyńska, Franciszek Herold
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 5, p 2329 (2021)
Two series of novel 4-aryl-2H-pyrido[1,2-c]pyrimidine (6a–i) and 4-aryl-5,6,7,8-tetrahydropyrido[1,2-c]pyrimidine (7a–i) derivatives were synthesized. The chemical structures of the new compounds were confirmed by 1H and 13C NMR spectroscopy and
Externí odkaz:
https://doaj.org/article/c4eac4054efd417aa89f45d49c6c6d82
Autor:
Mikhail Krasavin, Andrzej J. Bojarski, Beata Duszyńska, Alexander Sapegin, Sergey Grintsevich
Publikováno v:
Synthesis. 54:658-666
Attempts to extend the hydrated imidazoline ring expansion (HIRE) strategy to a series of diarene-fused [1,4]diazepinones (earlier applied successfully to bis-pyrido substrate nevirapine) did not result in ring expansion but, rather, led to 2-aminoet
Autor:
Robert W. Garvey, Enza Lacivita, Mauro Niso, Beata Duszyńska, Paul E. Harris, Marcello Leopoldo
Publikováno v:
ChemMedChem. 17
Autor:
Raul R. Gainetdinov, Andrzej J. Bojarski, Evgeny V. Kanov, Alexander Sapegin, Mikhail Krasavin, Beata Duszyńska, Anatoly A. Peshkov
Publikováno v:
Mendeleev Communications. 31:501-503
Di(het)areno-fused 1,4,7-(oxa)thiadiazecanes were synthesized by the reduction of the corresponding ten-membered lactams obtained, in turn, via the ‘hydrated imidazoline ring expansion’ (HIRE) methodology. Two of them displayed micromolar agonist
Autor:
Anna, Stankiewicz, Katarzyna, Kaczorowska, Ryszard, Bugno, Aneta, Kozioł, Maria H, Paluchowska, Grzegorz, Burnat, Barbara, Chruścicka, Paulina, Chorobik, Piotr, Brański, Joanna M, Wierońska, Beata, Duszyńska, Andrzej, Pilc, Andrzej J, Bojarski
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry
article-version (VoR) Version of Record
article-version (VoR) Version of Record
Considering the allosteric regulation of mGlu receptors for potential therapeutic applications, we developed a group of 1,2,4-oxadiazole derivatives that displayed mGlu4 receptor positive allosteric modulatory activity (EC50 = 282–656 nM). Selectiv