Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Beata, Tylińska"'
Autor:
Beata Tylińska, Benita Wiatrak
Publikováno v:
Biology, Vol 10, Iss 6, p 564 (2021)
Olivacine and its derivatives are characterized by multidirectional biological activity. Noteworthy is their antiproliferative effect related to various mechanisms, such as inhibition of growth factors, enzymes, kinases and others. The activity of th
Externí odkaz:
https://doaj.org/article/7f4ed05834af4fe787ca1b92615f6eac
Publikováno v:
Molecules, Vol 25, Iss 11, p 2512 (2020)
Olivacine is an alkaloid-containing pyridocarbazole structure. It is isolated from the bark of the evergreen timber tree, Aspidosperma olivaceum. Its well-documented anticancer activity led to the synthesis of new derivatives, which are semisynthetic
Externí odkaz:
https://doaj.org/article/c5bf23961b0d4b85945766544c8c1be9
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 11; Pages: 6119
Ellipticine is an indole alkaloid with proven antitumor activity against various tumors in vitro and a diverse mechanism of action, which includes topoisomerase II inhibition, intercalation, and cell cycle impact. Olivacine—ellipticine’s isomer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab51e220d4b0bc2c27b276281962a27e
https://pubmed.ncbi.nlm.nih.gov/35682799
https://pubmed.ncbi.nlm.nih.gov/35682799
Autor:
Jan Spychala, Agnieszka Dobosz, Żaneta Czyżnikowska, Amadeusz Kuźniarski, Łucja Cwynar-Zając, Beata Tylińska, Tomasz Gębarowski
Publikováno v:
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 8492, p 8492 (2021)
Volume 22
Issue 16
International Journal of Molecular Sciences, Vol 22, Iss 8492, p 8492 (2021)
Volume 22
Issue 16
Olivacine and ellipticine are model anticancer drugs acting as topoisomerase II inhibitors. Here, we present investigations performed on four olivacine derivatives in light of their antitumor activity. The aim of this study was to identify the best a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ce39043c88904926e598a1fa546f7fa
https://pubmed.ncbi.nlm.nih.gov/34445198
https://pubmed.ncbi.nlm.nih.gov/34445198
Publikováno v:
Anti-cancer agents in medicinal chemistry. 22(13)
Background: Despite the dynamic development of medicine, globally cancer diseases remain the second leading cause of death. Therefore, there is a strong necessity to improve chemotherapy regimens and search for new anticancer agents. Pyridocarbazoles
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38e9bd98e499228a68bbe767fb4e109a
https://pubmed.ncbi.nlm.nih.gov/34906061
https://pubmed.ncbi.nlm.nih.gov/34906061
Autor:
Anna Janicka-Klos, Elżbieta Gębarowska, Beata Tylińska, Aneta Cieśla-Niechwiadowicz, Żaneta Czyżnikowska, Benita Wiatrak
Publikováno v:
International Journal of Molecular Sciences
Volume 22
Issue 8
International Journal of Molecular Sciences, Vol 22, Iss 3825, p 3825 (2021)
Volume 22
Issue 8
International Journal of Molecular Sciences, Vol 22, Iss 3825, p 3825 (2021)
In the present paper, new pyrimidine derivatives were designed, synthesized and analyzed in terms of their anticancer properties. The tested compounds were evaluated in vitro for their antitumor activity. The cytotoxic effect on normal human dermal f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06393b485b29db6e622a0322d6c2180e
Publikováno v:
Molecules
Volume 25
Issue 11
Molecules, Vol 25, Iss 2512, p 2512 (2020)
Volume 25
Issue 11
Molecules, Vol 25, Iss 2512, p 2512 (2020)
Olivacine is an alkaloid-containing pyridocarbazole structure. It is isolated from the bark of the evergreen timber tree, Aspidosperma olivaceum. Its well-documented anticancer activity led to the synthesis of new derivatives, which are semisynthetic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdb3fd861f2d91d0b0c7a0cc17c3f871
Autor:
Tomasz Gębarowski, Katarzyna Szczaurska-Nowak, Karina Kowalczewska, Beata Tylińska, Ryszard Jasztold-Howorko, Joanna Wietrzyk
Publikováno v:
Acta Poloniae Pharmaceutica - Drug Research. 75:1313-1320
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4cf85a2c2f5d90cf5c0f9514596ec6ef
https://doi.org/10.32383/appdr/89921
https://doi.org/10.32383/appdr/89921
Publikováno v:
Pharmacological reports : PR. 72(1)
BackgroundThe p53 protein is a transcription factor for many genes, including genes involved in inhibiting cell proliferation and inducing apoptosis in genotoxically damaged and tumor-transformed cells. In more than 55% of cases of human cancers, los
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcf686456e40aacdf186e718aba98106
https://pubmed.ncbi.nlm.nih.gov/32016852
https://pubmed.ncbi.nlm.nih.gov/32016852
Autor:
Beata, Tylińska, Ryszard, Jasztold-Howorko, Henryk, Mastalarz, Katarzyna, Szczaurska-Nowak, Paulina, Materek, Joanna, Wietrzyk
Publikováno v:
Acta poloniae pharmaceutica. 68(1)
A number of new 1-substituted-6H-pyrido[4,3-b]carbazole derivatives have been synthesized. Nine of the newly obtained compounds were subjected to preliminary in vitro cytostatic activity screening against murine leukemia (L1210), human lung cancer (A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d5f38199ea882c99874b9f54c5ed994d
https://pubmed.ncbi.nlm.nih.gov/21485699
https://pubmed.ncbi.nlm.nih.gov/21485699