Zobrazeno 1 - 10
of 237
pro vyhledávání: '"Beat W Schäfer"'
Autor:
Joana G Marques, Berkley E Gryder, Blaz Pavlovic, Yeonjoo Chung, Quy A Ngo, Fabian Frommelt, Matthias Gstaiger, Young Song, Katharina Benischke, Dominik Laubscher, Marco Wachtel, Javed Khan, Beat W Schäfer
Publikováno v:
eLife, Vol 9 (2020)
The NuRD complex subunit CHD4 is essential for fusion-positive rhabdomyosarcoma (FP-RMS) survival, but the mechanisms underlying this dependency are not understood. Here, a NuRD-specific CRISPR screen demonstrates that FP-RMS is particularly sensitiv
Externí odkaz:
https://doaj.org/article/d33cd1744564400abf93c1226f3c6a09
Autor:
Sara G. Danielli, Yun Wei, Michael A. Dyer, Elizabeth Stewart, Heather Sheppard, Marco Wachtel, Beat W. Schäfer, Anand G. Patel, David M. Langenau
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Rhabdomyosarcoma (RMS) is a pediatric tumor that resembles undifferentiated muscle cells; yet the extent to which cell state heterogeneity is shared with human development has not been described. Using single-cell/nucleus RNA sequencing from
Externí odkaz:
https://doaj.org/article/e29faed2ad884c858ba654d0b6fb5c27
Autor:
Patricia Jaaks, Valentina D'Alessandro, Nicole Grob, Sina Büel, Katarina Hajdin, Beat W Schäfer, Michele Bernasconi
Publikováno v:
PLoS ONE, Vol 11, Iss 8, p e0161396 (2016)
The proprotein convertase (PC) furin cleaves precursor proteins, an important step in the activation of many cancer-associated proteins. Substrates of furin and furin-like PCs play a role in proliferation, metastasis and invasion. Some of them are in
Externí odkaz:
https://doaj.org/article/5eef75ee3e434a0da54a3997f5446aeb
Publikováno v:
Frontiers in Oncology, Vol 3 (2013)
Rhabdomyosarcoma (RMS) and Ewing sarcoma (ES) are among the most common pediatric sarcomas (Arndt et al., 2012). Despite sarcomas representing a highly heterogeneous group of tumors, ES and alveolar RMS (ARMS) typically share one common genetic chara
Externí odkaz:
https://doaj.org/article/b04fccd8cec14d89aae876dff5f71ebf
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e55072 (2013)
A subset of paediatric sarcomas are characterized by chromosomal translocations encoding specific oncogenic transcription factors. Such fusion proteins represent tumor specific therapeutic targets although so far it has not been possible to directly
Externí odkaz:
https://doaj.org/article/ce8ca80972ce48db94d68cee6103ebfa
Autor:
Dagmar Walter, Sampoorna Satheesha, Patrick Albrecht, Beat C Bornhauser, Valentina D'Alessandro, Susanne M Oesch, Hubert Rehrauer, Ivo Leuschner, Ewa Koscielniak, Carole Gengler, Holger Moch, Michele Bernasconi, Felix K Niggli, Beat W Schäfer, CWS Study Group
Publikováno v:
PLoS ONE, Vol 6, Iss 5, p e19506 (2011)
Cancer stem cells (CSCs) have been identified in a number of solid tumors, but not yet in rhabdomyosarcoma (RMS), the most frequently occurring soft tissue tumor in childhood. Hence, the aim of this study was to identify and characterize a CSC popula
Externí odkaz:
https://doaj.org/article/56c734754ee2452c8bdbde2a3b90d5c1
Publikováno v:
PLoS ONE, Vol 5, Iss 5, p e10445 (2010)
Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children. Improvement of treatment efficacy and decreased side effects through tumor-targeted drug delivery would be desirable. By panning with a phage-displayed cyclic random peptide l
Externí odkaz:
https://doaj.org/article/e48e36bd63de4c71885c00d66b97a2f8
Autor:
Yaw Asante, Katharina Benischke, Issra Osman, Quy A. Ngo, Jakob Wurth, Dominik Laubscher, Hyunmin Kim, Bhavatharini Udhayakumar, Md Imdadul H. Khan, Diana H. Chin, Jadon Porch, Maharshi Chakraborty, Richard Sallari, Olivier Delattre, Sakina Zaidi, Sarah Morice, Didier Surdez, Sara G. Danielli, Beat W. Schäfer, Berkley E. Gryder, Marco Wachtel
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract Activation of oncogenic gene expression from long-range enhancers is initiated by the assembly of DNA-binding transcription factors (TF), leading to recruitment of co-activators such as CBP/p300 to modify the local genomic context and facili
Externí odkaz:
https://doaj.org/article/8b11c89f44b84a3f89f0cbe46cf89665
Autor:
Vadim Saratov, Quy A. Ngo, Gloria Pedot, Semjon Sidorov, Marco Wachtel, Felix K. Niggli, Beat W. Schäfer
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-15 (2022)
Abstract As the second most common pediatric bone and soft tissue tumor, Ewing sarcoma (ES) is an aggressive disease with a pathognomonic chromosomal translocation t(11;22) resulting in expression of EWS-FLI1, an “undruggable” fusion protein acti
Externí odkaz:
https://doaj.org/article/a89a844999154563b8c8a1db91001c39
Autor:
Dominik Laubscher, Berkley E. Gryder, Benjamin D. Sunkel, Thorkell Andresson, Marco Wachtel, Sudipto Das, Bernd Roschitzki, Witold Wolski, Xiaoli S. Wu, Hsien-Chao Chou, Young K. Song, Chaoyu Wang, Jun S. Wei, Meng Wang, Xinyu Wen, Quy Ai Ngo, Joana G. Marques, Christopher R. Vakoc, Beat W. Schäfer, Benjamin Z. Stanton, Javed Khan
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Rhabdomyosarcoma (RMS) is a pediatric malignancy of skeletal muscle lineage with an aggressive subtype caused by translocations involving PAX3- /PAX7-FOXO1 chimeric transcription factors. Here the authors show that the BRG1-containing BAF complex is
Externí odkaz:
https://doaj.org/article/3a3e0d79c30a410f82f8195b27c0b538