Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Beat M. Künzli"'
Autor:
Mireia Martín-Satué, Beat M. Künzli, Bilha Fischer, Jean Sévigny, Donald Poirier, Irina Gillerman, Mercedes N. Munkonda, Joanna Lecka, Michel Fausther, Christine Cadot, Eric Rousseau, Mabrouka Salem, Pedro D'Orléans-Juste, Jean-Philippe Brosseau
Publikováno v:
British Journal of Pharmacology. 169:179-196
Background and Purpose Ectonucleotidases control extracellular nucleotide levels and consequently, their (patho)physiological responses. Among these enzymes, nucleoside triphosphate diphosphohydrolase-1 (NTPDase1), −2, −3 and −8 are the major e
Autor:
Mikolaj Walensi, Anne Zuse, Christoph A. Maurer, René Lötscher, Beat M. Künzli, Samuel A. Käser
Publikováno v:
World journal of hepatology. 8(24)
AIM: To evaluate liver resections without Pringle maneuver, i.e., clamping of the portal triad. METHODS: Between 9/2002 and 7/2013, 175 consecutive liver resections (n = 101 major anatomical and n = 74 large atypical > 5 cm) without Pringle maneuver
Autor:
Beat M. Künzli, Helmut Friess, Robert D. Rosenberg, Matthias Maak, Tibor Schuster, Ulrich Nitsche
Publikováno v:
European Surgery. 44:47-53
BACKGROUND: The aim of the study was to evaluate prognostic factors and survival improvements in stage IV colorectal cancer patients who had all undergone resection of their primary tumor. METHODS: Between 1982 and 2006, 639 consecutive patients with
Autor:
Matthias Maak, Klaus-Peter Janssen, Julia Slotta-Huspenina, Beat M. Künzli, Rupert Langer, Ulrich Nitsche, Tibor Schuster, Robert D. Rosenberg, Helmut Friess
Publikováno v:
Annals of Surgery. 254:793-801
To compare the prognostic value of the sixth and seventh editions of the TNM classification, and of additional prognostic factors, in colorectal cancer.The seventh TNM edition was released in 2009 with the aim of providing a more precise prediction o
Autor:
Anthony J F D'Apice, Peter J. Cowan, Helmut Friess, Keiichi Enjyoji, Aurel Perren, Eva Csizmadia, Beat M. Künzli, Christoph A. Maurer, Maria-Isabell Bernlochner, Stephan Rath, Karen M. Dwyer, Robert D. Rosenberg, Simon C. Robson, Samuel A. Käser
Publikováno v:
Künzli, Beat M; Bernlochner, Maria-Isabell; Rath, Stephan; Käser, Samuel; Csizmadia, Eva; Enjyoji, Keiichi; Cowan, Peter; d'Apice, Anthony; Dwyer, Karen; Rosenberg, Robert; Perren, Aurel; Friess, Helmut; Maurer, Christoph A; Robson, Simon C (2011). Impact of CD39 and purinergic signalling on the growth and metastasis of colorectal cancer. Purinergic signalling, 7(2), pp. 231-41. Dordrecht: Springer 10.1007/s11302-011-9228-9
Despite improvements in prevention and management of colorectal cancer (CRC), uncontrolled tumor growth with metastatic spread to distant organs remains an important clinical concern. Genetic deletion of CD39, the dominant vascular and immune cell ec
Autor:
Helmut Friess, Beat M. Künzli, Keiichi Enjyoji, Pascal O. Berberat, Simon C. Robson, David J. Friedman, Yousif I. A-Rahim, Jean Sévigny, Eva Csizmadia
Publikováno v:
Proceedings of the National Academy of Sciences. 106:16788-16793
CD39/ENTPD1 hydrolyzes proinflammatory nucleotides to generate adenosine. As purinergic mediators have been implicated in intestinal inflammation, we hypothesized that CD39 might protect against inflammatory bowel disease. We studied these possibilit
Autor:
Mercedes N. Munkonda, Alain Tremblay, Jean Sévigny, Terence L. Kirley, Julie Pelletier, Beat M. Künzli, Vasily V. Ivanenkov, Michel Fausther
Publikováno v:
FEBS Journal. 276:479-496
The study and therapeutic modulation of purinergic signaling is hindered by a lack of specific inhibitors for NTP diphosphohydrolases (NTPDases), which are the terminating enzymes for these processes. In addition, little is known of the NTPDase prote
Autor:
Hans Geinitz, Markus Schwaiger, Robert Rosenberg, Ken Herrmann, Ralf Gertler, Bernd J. Krause, J. R. Siewert, Beat M. Künzli, Tibor Schuster, Matthias Maak, Markus Essler, Florian Lordick, Karen Becker
Publikováno v:
International Journal of Colorectal Disease. 24:191-200
To evaluate the value of positron emission tomography using fluorodeoxyglucose and computer tomography scan (FDG-PET/CT) for prediction of histopathological response of preoperative radiochemotherapy (RCTX) in patients with rectal carcinoma.Thirty pa
Autor:
Beat M. Künzli, K. Becker, Sarah Keates, Sunil A Sheth, Pelayo Correa, Maria Blanca Piazuelo, Richard M. Peek, Ciaran P. Kelly, Sanjeev Tummala, Eva Csizmadia, Simon C. Robson, Judith Romero-Gallo, Andrew C. Keates
Publikováno v:
Infection and Immunity. 76:3992-3999
Chronic infection with the gastric pathogen Helicobacter pylori significantly increases the risk of developing atrophic gastritis, peptic ulcer disease, and gastric adenocarcinoma. H. pylori strains that possess the cag pathogenicity island, which tr
Autor:
Beat M. Künzli, Matthias Löhr, Hans-Ulrich Schulz, Tomas Hucl, Roland H. Pfützer, Heiko Witt, Alexander Schneider, Esko Kemppainen, Thomas M. Gress, Marko Lempinen, Manfred V. Singer, Helmut Friess, Marja-Leena Kylänpää-Bäck, Johann Ockenga, Jonas Rosendahl
Publikováno v:
Genetics in Medicine. 9:479-483
Purpose: The homozygous p.C282Y variant of the HFE gene is a major risk factor for hereditary hemochromatosis, a disorder of iron metabolism resulting in progressive iron accumulation in a variety of organs including the pancreas. Heterozygosity of p