Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Beat Flühmann"'
Autor:
Reinaldo Digigow, Michael Burgert, Marco Luechinger, Alla Sologubenko, Andrzej J. Rzepiela, Stephan Handschin, Amy E. Barton Alston, Beat Flühmann, Erik Philipp
Publikováno v:
Heliyon, Vol 10, Iss 17, Pp e36749- (2024)
Iron deficiency and iron deficiency anemia pose significant health challenges worldwide. Iron carbohydrate nanoparticles administered intravenously are a mainstay of treatment to deliver elemental iron safely and effectively. However, despite decades
Externí odkaz:
https://doaj.org/article/85e1a53b26364476915f7c06272ec899
Autor:
Jonas Bossart, Alexandra Rippl, Amy E. Barton Alston, Beat Flühmann, Reinaldo Digigow, Marija Buljan, Vanesa Ayala-Nunez, Peter Wick
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 166, Iss , Pp 115404- (2023)
Iron-carbohydrate complexes are widely used to treat iron deficiencies. Macrophages play a crucial role in the uptake and fate of these nanomedicines, however, how complexed iron carbohydrates are taken up and metabolized by macrophages is still not
Externí odkaz:
https://doaj.org/article/6ff10619d272479e9c59c72af0439ad9
Autor:
Gulsah Sevimli, Amy E. Alston, Felix Funk, Beat Flühmann, Roland Malli, Wolfgang F. Graier, Emrah Eroglu
Publikováno v:
Biosensors, Vol 12, Iss 10, p 903 (2022)
Cellular iron supply is required for various biochemical processes. Measuring bioavailable iron in cells aids in obtaining a better understanding of its biochemical activities but is technically challenging. Existing techniques have several constrain
Externí odkaz:
https://doaj.org/article/31184a3dafdc4f20a605c5aaad6a06c6
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 18, p 10230 (2022)
The authors wish to make the following corrections to this paper [...]
Externí odkaz:
https://doaj.org/article/5f3aeebfdc224211b8c2e96723786078
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 4, p 2140 (2022)
Un-complexed polynuclear ferric oxyhydroxide cannot be administered safely or effectively to patients. When polynuclear iron cores are formed with carbohydrates of various structures, stable complexes with surface carbohydrates driven by multiple int
Externí odkaz:
https://doaj.org/article/62f4cddf7b844981a3f6e5954e10da6e
Autor:
Tasneem Arsiwala, Anne-Cathrine S. Vogt, Amy E. Barton, Vania Manolova, Felix Funk, Beat Flühmann, Martin F. Bachmann
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 5, p 2666 (2022)
Intravenous (IV) iron nanoparticle preparations are widely used to treat iron deficiency. The mechanism of mononuclear phagocyte system-mediated clearance of IV iron nanoparticles is unknown. The early uptake and homeostasis of iron after injection o
Externí odkaz:
https://doaj.org/article/8cfcd5c342fc474bb94e679fbc4471e8
Autor:
Amy E. Barton, Gerrit Borchard, Matthias G. Wacker, Giorgia Pastorin, Imran Y. Saleem, Shaqil Chaudary, Tamer Elbayoumi, Zhigang Zhao, Beat Flühmann
Publikováno v:
Pharmacy, Vol 10, Iss 1, p 17 (2022)
The emerging landscape of nanomedicine includes a wide variety of active pharmaceutical ingredients and drug formulations. Their design provides nanomedicines with unique features leading to improved pharmacokinetics and pharmacodynamics. They are ma
Externí odkaz:
https://doaj.org/article/bb2e36ad2059411788fcf5480a25fbb8
Autor:
Natalia Sofia, Stefan Mühlebach, Umberto M. Musazzi, Rani Khatib, José Manuel Martinez Sesmero, Hans-Peter Lipp, Jacqueline Surugue, Tiziana Di Francesco, Beat Flühmann
Publikováno v:
Pharmaceutics, Vol 13, Iss 7, p 1010 (2021)
We conducted research to assess hospital pharmacists’ familiarity with/interpretation of data requirements for the different regulatory approval frameworks and the impact of this on their approach to substitution in the formulary. The online questi
Externí odkaz:
https://doaj.org/article/b9e24f1eed5142b28728218642c8e1fb
Publikováno v:
European Journal of Pharmaceutics and Biopharmaceutics. 188:6-14
Autor:
Vinod P. Shah, Jon S. B. de Vlieger, Scott E McNeil, Kevin Klein, Beat Flühmann, Gerrit Borchard
Publikováno v:
Annals of the New York Academy of Sciences
The diverse nature of complex drug products poses challenges for the development of regulatory guidelines for generic versions. While complexity is not new in medicines, the technical capacity to measure and analyze data has increased. This requires