Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Beat, Thalmann"'
Autor:
Inska S. Reichstein, Maria König, Niklas Wojtysiak, Beate I. Escher, Luise Henneberger, Peter Behnisch, Harrie Besselink, Beat Thalmann, Julien Colas, Sarah Hörchner, Henner Hollert, Andreas Schiwy
The evaluation of single substances or environmental samples for their genotoxic or estrogenic potential is highly relevant for human- and environment-related risk assessment. To examine the effects on a mechanism-specific level, standardized cell-ba
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21839c354ae002eb076ccfb5ec23fa44
https://publica.fraunhofer.de/handle/publica/437578
https://publica.fraunhofer.de/handle/publica/437578
Autor:
Beat Thalmann, Yvonne Müller, Kilian E. C. Smith, Henriette Meyer-Alert, Henner Hollert, Markus Hecker, Danielle Carrière, Markus Brinkmann, Bogdan Barz, Simone Hotz, Sabrina Schiwy, Mirna Velki, Kerstin Bluhm, Andreas Tiehm, Helena Salowsky
Publikováno v:
Chemical Research in Toxicology. 32:698-707
Hydroxylation of polyaromatic compounds through cytochromes P450 (CYPs) is known to result in potentially estrogenic transformation products. Recently, there has been an increasing awareness of the importance of alternative pathways such as aldehyde
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5854d473ccd8f4a4b59dcd335e15f8b1
https://doi.org/10.1021/acs.chemrestox.8b00372
https://doi.org/10.1021/acs.chemrestox.8b00372
Autor:
Thomas-Benjamin Seiler, Beat Thalmann, Zhongli Chen, Shangbo Zhou, Henner Hollert, Linyan Zhu, Ying Shao
Publikováno v:
The Science of the total environment. 787
The increasing concern over bisphenol A (BPA) has directed much attention toward bisphenol F (BPF) and bisphenol S (BPS) as BPA alternatives for the development of "BPA-free" products. Consequently, BPS and BPF were frequently detected in surface wat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd4dab8a10023112b99782f7996142b0
https://pubmed.ncbi.nlm.nih.gov/34000551
https://pubmed.ncbi.nlm.nih.gov/34000551
Autor:
Rita Schlichting, Maria König, Beate I. Escher, Beat Thalmann, Luise Henneberger, Lisa Glauch, Ying Shao, Hongxia Xiao, Henner Hollert, Andreas Schiwy, Marie Mühlenbrink
Publikováno v:
The Science of the total environment. 749
Many environmental pollutants pose a toxicological hazard only after metabolic activation. In vitro bioassays using cell lines or bacteria have often no or reduced metabolic activity, which impedes their use in the risk assessment. To improve the pre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abc6f0bf0ad0ac0428b52439b5a31abb
https://pubmed.ncbi.nlm.nih.gov/32827816
https://pubmed.ncbi.nlm.nih.gov/32827816
Publikováno v:
Environmental Science and Pollution Research. 25:4012-4022
The binding of the p53 tumor suppression protein to DNA response elements after genotoxic stress can be quantified by cell-based reporter gene assays as a DNA damage endpoint. Currently, bioassay evaluation of environmental samples requires further k
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97e641aa9d13d2f7727e115cb0bf75dd
https://doi.org/10.1007/s11356-017-8790-2
https://doi.org/10.1007/s11356-017-8790-2
Autor:
Andreas Schiwy, Julia Brendt, Mirna Velki, Hongxia Xiao, Beat Thalmann, Sarah E. Crawford, Henner Hollert
Publikováno v:
Science of The Total Environment. 759:143522
Metabolism has to be considered during the toxicological assessment of chemical and environmental samples because it is an important process in the mammalian liver. It can be assessed in vitro via liver homogenates called S9-fractions, an external me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e20e7cc33aa74e4b45a9eddabb225b8
https://doi.org/10.1016/j.scitotenv.2020.143522
https://doi.org/10.1016/j.scitotenv.2020.143522
Autor:
Hongxia Xiao, Henner Hollert, Julia Brendt, Sarah E. Crawford, Beat Thalmann, Mirna Velki, Carina Lackmann, Sebastian Heger, Andreas Schiwy
Publikováno v:
Science of The Total Environment. 751:142269
This study presents a high-throughput (HTP) micronucleus assay in multi-well plates with an automated evaluation for risk assessment applications. The evaluation of genotoxicity via the micronucleus assays according to international guidelines ISO 21
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7dc5f9f715f87c59555f6accbc9742ee
https://doi.org/10.1016/j.scitotenv.2020.142269
https://doi.org/10.1016/j.scitotenv.2020.142269
Autor:
Beat Thalmann, Bryanna K. Eisner, Kathrin Eichbaum, Steve Wiseman, Sebastian Buchinger, Georg Reifferscheid, Henner Hollert, Markus Brinkmann, Sven Koglin, Markus Hecker
Publikováno v:
Science of The Total Environment. 541:412-423
There is significant concern regarding the contamination of riverine sediments with dioxins and dioxin-like compounds (DLCs), including polychlorinated dibenzo-p-dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs), polychlorinated biphenyls (PCBs)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8cd108780dd31085fd1add8d99565f3
https://doi.org/10.1016/j.scitotenv.2015.09.087
https://doi.org/10.1016/j.scitotenv.2015.09.087
Autor:
Thomas-Benjamin Seiler, Markus Brinkmann, Leonie Nüßer, Beat Thalmann, Andreas Schiwy, Henner Hollert, Kathrin Eichbaum, Brigitte Thoms, Gabriele Guder, Ines Thiem, Kerstin Winkens, Sebastian Buchinger, Georg Reifferscheid
Publikováno v:
Nature Protocols. 10:1728-1741
This protocol describes a quantitative and robust 96-well-plate-reader-based assay for the measurement of ethoxyresorufin-O-deethylase (EROD) activity using the rat hepatoma cell line H4IIE. The assay can be used to determine the cytochrome P450 subf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d99960058f68af2f2881dc76489ad8d5
https://doi.org/10.1038/nprot.2015.108
https://doi.org/10.1038/nprot.2015.108
Autor:
Beat Thalmann, Kathrin Eichbaum, Carolin Gembé, Andreas Schiwy, Christine Achten, Hongxia Xiao, Markus Brinkmann, Sigrid Große Brinkhaus, Henner Hollert, Thomas-Benjamin Seiler
Publikováno v:
Environmental sciencetechnology. 51(6)
Effect-directed analysis (EDA) is a powerful strategy to identify biologically active compounds in environmental samples. However, in current EDA studies, fractionation and handling procedures are laborious, consist of multiple evaporation steps, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4589a59d9eb416ce3a7911110e71e410
https://pubmed.ncbi.nlm.nih.gov/28190338
https://pubmed.ncbi.nlm.nih.gov/28190338