Protein Kinase C inhibition ameliorates functional endothelial insulin resistance and Vascular Smooth Muscle Cell hypersensitivity to insulin in diabetic hypertensive rats

Autor: Bean James S, Kassab Ghassan S, Lu Xiao, Rekhter Mark D

Publikováno v: Cardiovascular Diabetology, Vol 10, Iss 1, p 48 (2011)

Abstract Objective Insulin resistance, diabetes, and hypertension are considered elements of metabolic syndrome which is associated with vascular dysfunction. We investigated whether inhibition of protein kinase C (PKC) would affect vascular function

Externí odkaz: https://doaj.org/article/ed91c5adb8444eb59032ba5d9e280437

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Raloxifene and Estrogen Inhibit Neointimal Thickening After Balloon Injury in the Carotid Artery of Male and Ovariectomized Female Rats.

Autor: Kauffman, Raymond F., Bean, James S., Fahey, Kennan J., Cullinan, George J., Cox, David A., Bensch, William R.

Publikováno v: Journal of Cardiovascular Pharmacology; Oct2000, Vol. 36 Issue 4, p459-465, 7p

Design and synthesis of alpha-aryloxy-alpha-methylhydrocinnamic acids: a novel class of dual peroxisome proliferator-activated receptor alpha/gamma agonists.

Autor: Xu Y; Lilly Research Laboratories, A Division of Eli Lilly & Company, Lilly Corporate Center, Indianapolis, Indiana 46285, USA. xu_yanping@lilly.com, Rito CJ, Etgen GJ, Ardecky RJ, Bean JS, Bensch WR, Bosley JR, Broderick CL, Brooks DA, Dominianni SJ, Hahn PJ, Liu S, Mais DE, Montrose-Rafizadeh C, Ogilvie KM, Oldham BA, Peters M, Rungta DK, Shuker AJ, Stephenson GA, Tripp AE, Wilson SB, Winneroski LL, Zink R, Kauffman RF, McCarthy JR

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2004 May 06; Vol. 47 (10), pp. 2422-5.