Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Beal McIlvain"'
Autor:
Linh Ma, H. Beal McIlvain, Melissa T. Manners, Edward J. Kaftan, Brian Ludwig, John Dunlop, Garth T. Whiteside, Jeffrey D. Kennedy, Robert Martone
Publikováno v:
European Journal of Pharmacology. 643:202-210
Microglia are commonly described as existing in resting or active states based on morphology or level of cytokine production. Extracellular ATP is a physiologically-relevant activator of microglia, which express a number of purinergic receptors. As P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60fdfa82ff18c78018e0dbab10fed49d
https://doi.org/10.1016/j.ejphar.2010.06.046
https://doi.org/10.1016/j.ejphar.2010.06.046
Publikováno v:
High Content Screening: Science, Techniques and Applications
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a55ef0a91b5e6558fa1c0ee09465a13f
https://doi.org/10.1002/9780470229866.ch7
https://doi.org/10.1002/9780470229866.ch7
Autor:
Alexander Greenfield, Tikva Carrick, John A. Butera, Dianne Kowal, John Dunlop, Brian Jow, Cristina Grosanu, Qiang Lu, Beal McIlvain, John P. Williams
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 15:4985-4988
Excitatory amino acid transporters (EAATs) play a pivotal role in maintaining glutamate homeostasis in the mammalian central nervous system, with the EAAT-2 subtype thought to be responsible for the bulk of the glutamate uptake in forebrain regions.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c5a1dd7bbb3e90347e18220f7cf664f
https://doi.org/10.1016/j.bmcl.2005.08.003
https://doi.org/10.1016/j.bmcl.2005.08.003
Autor:
Diana Chen, Flora Jow, Beal McIlvain, Eugene Tseng, KeWei Wang, Howard Zhang, Qin Jennifer Shan, Qiang Lu, Dianne Kowal, Ru Shen, Lan He, John Dunlop
Publikováno v:
ASSAY and Drug Development Technologies. 2:525-534
M-channels (M-current), encoded by KCNQ2/3 K(+) channel genes, have emerged as novel drug targets for a number of neurological disorders. The lack of direct high throughput assays combined with the low throughput of conventional electrophysiology (EP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64da878443a95137a291fab9c5b4ad69
https://doi.org/10.1089/adt.2004.2.525
https://doi.org/10.1089/adt.2004.2.525
Autor:
John Dunlop, Dianne Kowal, Scott Eliasof, Tikva Carrick, Alexander Greenfield, Robert E. Petroski, H. Beal McIlvain, Gary Paul Stack
Publikováno v:
British Journal of Pharmacology. 140:839-846
The pharmacological profile of a novel glutamate transport inhibitor, WAY-855 (3-amino-tricyclo[2.2.1.02.6]heptane-1,3-dicarboxylic acid), on the activity of the human forebrain glutamate transporters EAAT1, EAAT2 and EAAT3 expressed in stable mammal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::054d06861d1364d0bb5256cf89f66a60
https://doi.org/10.1038/sj.bjp.0705509
https://doi.org/10.1038/sj.bjp.0705509
Publikováno v:
Journal of Neurochemistry. 77:550-557
The glutamate analog (±) threo-3-methylglutamate (T3MG) has recently been reported to inhibit the EAAT2 but not EAAT1 subtype of high-affinity, Na+-dependent excitatory amino acid transporter (EAAT). We have examined the effects of T3MG on glutamate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2a12c8f54feaf2f5524773bce4089f81
https://doi.org/10.1046/j.1471-4159.2001.00253.x
https://doi.org/10.1046/j.1471-4159.2001.00253.x
Publikováno v:
Brain Research. 839:235-242
In this study, we describe the presence of Na(+)-dependent high-affinity L-glutamate transport activity in the human U373 astrocytoma cell line. U373 cells exhibited a robust accumulation of L-glutamate which was predominantly (85%) extracellular Na(
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cff9fd425e6408483689f4b8dc00be7
https://doi.org/10.1016/s0006-8993(99)01714-x
https://doi.org/10.1016/s0006-8993(99)01714-x
Publikováno v:
Journal of Gerontology. 47:B190-B197
Potassium (K+)-induced norepinephrine (NE) release was examined in preparations of cardiac synaptosomes and sliced atria from 6-, 24-, and 26-mo-old male F344 rats. Cardiac synaptosomes were prepared from rat hearts by collagenase digestion followed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47e2bc4da00c4ec0afdd486e251f847b
https://doi.org/10.1093/geronj/47.6.b190
https://doi.org/10.1093/geronj/47.6.b190
Publikováno v:
Experimental Biology and Medicine. 199:453-458
A cardiac synaptosomal preparation developed by this laboratory was used to study neuronal calcium channels in aging rat heart. Ca2+ channels were quantified by measuring binding of iodinated omega conotoxin, which is reported to specifically block n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::275b2d6b24bf4450f00dedcb93ed9025
https://doi.org/10.3181/00379727-199-43380
https://doi.org/10.3181/00379727-199-43380
Autor:
Stan P. Nawoschik, John Dunlop, Beal McIlvain, Steven P. Braithwaite, Jennifer Moore, Vasanti S. Anand, Brian Ludwig
Publikováno v:
Alzheimer's & Dementia. 4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f2cb9bcc22e3d5e9f6adcb3cd9264f40
https://doi.org/10.1016/j.jalz.2008.05.1206
https://doi.org/10.1016/j.jalz.2008.05.1206