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IFN-γ-response mediator GBP-1 represses human cell proliferation by inhibiting the Hippo signaling transcription factor TEAD

Autor: Jürgen Behrens, Bea Unterer, Marina Leone, Clara Tenkerian, Felix B. Engel, Heinrich Sticht, Nathalie Britzen-Laurent, Mekala Gunasekaran, Thomas Wittenberg, Elisabeth Naschberger, Veit Wiesmann, Michael Stürzl

Publikováno v: Biochemical Journal

Interferon-gamma (IFN-γ) is a pleiotropic cytokine that exerts important functions in inflammation, infectious diseases, and cancer. The large GTPase human guanylate-binding protein 1 (GBP-1) is among the most strongly IFN-γ-induced cellular protei

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d681d1b9ae071d0f8692797d989fb0d5
http://europepmc.org/articles/PMC6156764

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The Importance of TM3-4 Loop Subdomains for Functional Reconstitution of Glycine Receptors by Independent Domains

Autor: Cord-Michael Becker, Bea Unterer, Carmen Villmann

Publikováno v: Journal of Biological Chemistry; Vol 287
Journal of Biological Chemistry

Truncated glycine receptors that have been found in human patients suffering from the neuromotor disorder hyperekplexia or in spontaneous mouse models resulted in non-functional ion channels. Rescue of function experiments with the lacking protein po

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c36821c4fd11e15b4806f109de8f0ad5
https://doi.org/10.1074/jbc.m112.376053

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