Rapid hyperpolarization and purification of the metabolite fumarate in aqueous solution

Autor: John W. Blanchard, Laurynas Dagys, Dmitry Budker, Eleonora Cavallari, Malcolm H. Levitt, Gerd Buntkowsky, Maksim Tsukanov, Danila A. Barskiy, Alexander Pines, Francesca Reineri, Kerstin Münnemann, Stephan Knecht, Silvio Aime, James Eills, Erik van Dyke, Peter Blümler, Bea Bliemel

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America 118(13), e2025383118 (2021). doi:10.1073/pnas.2025383118
Proceedings of the National Academy of Sciences of the United States of America, vol 118, iss 13
Proceedings of the National Academy of Sciences
chemRxiv
Proceedings of the National Academy of Sciences of the United States of America

Significance Magnetic resonance imaging is hindered by inherently low sensitivity, which limits the method for the most part to observing water molecules in the body. Hyperpolarized molecules exhibit strongly enhanced MRI signals which opens the door

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