Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Beáta Dérfalvi"'
Autor:
Cristiane J. Nunes-Santos, HyeSun Kuehn, Brigette Boast, SuJin Hwang, Douglas B. Kuhns, Jennifer Stoddard, Julie E. Niemela, Danielle L. Fink, Stefania Pittaluga, Mones Abu-Asab, John S. Davies, Valarie A. Barr, Tomoki Kawai, Ottavia M. Delmonte, Marita Bosticardo, Mary Garofalo, Magda Carneiro-Sampaio, Raz Somech, Mohammad Gharagozlou, Nima Parvaneh, Lawrence E. Samelson, Thomas A. Fleisher, Anne Puel, Luigi D. Notarangelo, Bertrand Boisson, Jean-Laurent Casanova, Beata Derfalvi, Sergio D. Rosenzweig
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract We describe the first cases of germline biallelic null mutations in ARPC5, part of the Arp2/3 actin nucleator complex, in two unrelated patients presenting with recurrent and severe infections, early-onset autoimmunity, inflammation, and dys
Externí odkaz:
https://doaj.org/article/70df5eaacfeb4302a635c2f9e2561b5d
Publikováno v:
Pediatric Rheumatology Online Journal, Vol 21, Iss 1, Pp 1-12 (2023)
Abstract Background Juvenile Idiopathic Arthritis (JIA) is the most prevalent chronic pediatric rheumatic disorder. In joints of JIA patients, aggressive phenotypic changes in fibroblast-like synoviocytes (FLS) of the synovial lining play a key role
Externí odkaz:
https://doaj.org/article/f0f8b3a5436f42c5be5a32a6c623de2d
Autor:
Timothy K. Vander Leek, Edmond S. Chan, Lori Connors, Beata Derfalvi, Anne K. Ellis, Julia E. M. Upton, Elissa M. Abrams
Publikováno v:
Allergy, Asthma & Clinical Immunology, Vol 17, Iss 1, Pp 1-6 (2021)
Abstract Background Safe and effective vaccines provide the first hope for mitigating the devastating health and economic impacts resulting from coronavirus disease 2019 (COVID-19) and related public health orders. Recent case reports of reactions to
Externí odkaz:
https://doaj.org/article/68a2c3a5a1534b14b9544d87ad32208a
Autor:
Sarah M. McAlpine, Sarah E. Roberts, John J. Heath, Fabian Käsermann, Andrew C. Issekutz, Thomas B. Issekutz, Beata Derfalvi
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Intravenous immunoglobulin (IVIG) is an effective immunomodulatory treatment for immune dysregulation diseases. However, the mechanisms by which it reduces systemic inflammation are not well understood. NK cell cytotoxicity is decreased by IVIG in wo
Externí odkaz:
https://doaj.org/article/ea9f95a0079b4145a5cc45eefede390a
Publikováno v:
PLoS ONE, Vol 15, Iss 4, p e0231664 (2020)
Natural killer (NK) cells are innate lymphocytes with functions that include target cell killing, inflammation and regulation. NK cells integrate incoming activating and inhibitory signals through an array of germline-encoded receptors to gauge the h
Externí odkaz:
https://doaj.org/article/383263259d494ef4b3dc4013270ba0f9
Autor:
Ali Al Maawali, Beata Derfalvi, Johan Van Limbergen, Andrew Issekutz, Thomas Issekutz, Hasan Ghandourah, Mohsin Rashid
Publikováno v:
Case Reports in Immunology, Vol 2020 (2020)
IPEX (immune dysregulation-polyendocrinopathy-enteropathy-X-linked) syndrome is a rare, potentially fatal multisystem disorder caused by mutations in the FOXP3 gene. This can lead to quantitative or functional deficiency of regulatory T cells (Treg),
Externí odkaz:
https://doaj.org/article/4349c271a3c74986931970e3ef6fab45
Autor:
Anikó E. Malik, Drew Slauenwhite, Sarah M. McAlpine, John G. Hanly, Jean S. Marshall, Beáta Dérfalvi, Thomas B. Issekutz
Publikováno v:
Frontiers in Medicine, Vol 11 (2024)
BackgroundThe role of type I and type III interferons (IFNs) in rheumatoid arthritis (RA) and juvenile idiopathic arthritis (JIA) is still poorly understood. The objective of this study was to examine the hypothesis that IFN expression profiles in th
Externí odkaz:
https://doaj.org/article/6604fe21c02a4a40848cb6c541f0e5ce
Autor:
Bence György, Tamás G Szabó, Lilla Turiák, Matthew Wright, Petra Herczeg, Zsigmond Lédeczi, Agnes Kittel, Anna Polgár, Kálmán Tóth, Beáta Dérfalvi, Gergő Zelenák, István Böröcz, Bob Carr, György Nagy, Károly Vékey, Steffen Gay, András Falus, Edit I Buzás
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e49726 (2012)
INTRODUCTION: Microvesicles (MVs), earlier referred to as microparticles, represent a major type of extracellular vesicles currently considered as novel biomarkers in various clinical settings such as autoimmune disorders. However, the analysis of MV
Externí odkaz:
https://doaj.org/article/21230d8ecb8440a199a5c48c7917810d
Autor:
Sarah M. McAlpine, Sarah E. Roberts, Breanna K.V. Hargreaves, Claire Bullock, Suzanne Ramsey, Elizabeth Stringer, Bianca Lang, Adam Huber, Bence György, Fruzsina Erdélyi, Thomas B. Issekutz, Beáta Dérfalvi
Publikováno v:
The Journal of rheumatology.
ObjectiveTo evaluate microRNA expression in synovial fluid (SF), plasma, and leukocytes from patients with juvenile idiopathic arthritis (JIA).MethodsMicroRNA expression in pooled JIA plasma and SF was assessed by absolute quantitative droplet digita
Autor:
Sneha Suresh, Joseline Zafack, Anne Pham-Huy, Beata Derfalvi, Manish Sadarangani, Athena McConnell, Bruce Tapiéro, Scott A. Halperin, Gaston De Serres, Jeffrey M Pernica, Karina A. Top
Publikováno v:
Allergy, Asthma & Clinical Immunology, Vol 18, Iss 1, Pp 1-13 (2022)
Abstract Background and objectives Safety and effectiveness concerns may preclude physicians from recommending vaccination in mild/moderate inborn errors of immunity (IEI). This study describes attitudes and practices regarding vaccination among phys
Externí odkaz:
https://doaj.org/article/50ff2c49bc5f44beb697dc7185e05158