Zobrazeno 1 - 10
of 564
pro vyhledávání: '"Bcr signaling"'
Autor:
Youngjae Hong, Kihyuck Kwak
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
B cells are the cornerstone of our body’s defense system, producing precise antibodies and safeguarding immunological memory for future protection against pathogens. While we have a thorough understanding of how naïve B cells differentiate into pl
Externí odkaz:
https://doaj.org/article/0f292592995c4b4992c1e0adaf1eb138
Autor:
Andreas Hildenbrand, Precious Cramer, Milena Bertolotti, Nathalie Sophia Kaiser, Kathrin Kläsener, Clara Muriel Nickel, Michael Reth, Albert Heim, Hartmut Hengel, Hans-Gerhard Burgert, Zsolt Ruzsics
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionThe early transcription unit 3 (E3) of human adenoviruses (HAdVs) encodes several immunoevasins, including the E3/49K protein, which is unique for species D of HAdVs. It is expressed as surface transmembrane protein and shed. E3/49K of HA
Externí odkaz:
https://doaj.org/article/7a5ba3131ec940d5b423370471844f5a
Autor:
Daniela Pérez-Pérez, Ezequiel M. Fuentes-Pananá, José Mizael Flores-Hermenegildo, Hector Romero-Ramirez, Leopoldo Santos-Argumedo, Manfred W. Kilimann, Juan Carlos Rodríguez-Alba, Gabriela Lopez-Herrera
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionLipopolysaccharide-responsive and beige-like anchor (LRBA) is a scaffolding protein that interacts with proteins such as CTLA-4 and PKA, the importance of which has been determined in various cell types, including T regulatory cells, B ce
Externí odkaz:
https://doaj.org/article/5f40d70b1ebd48cca8a7216414b8168c
Publikováno v:
Hematology Reports, Vol 16, Iss 1, Pp 164-178 (2024)
Non-Hodgkin’s lymphomas (NHLs) are a heterogeneous group of lymphoproliferative disorders originating from B, T, or NK lymphocytes. They represent approximately 4–5% of new cancer cases and are classified according to the revised WHO system based
Externí odkaz:
https://doaj.org/article/5eb788933dbd474fb6ef7b84228d6ccc
Autor:
Vera K. Schmid, Elias Hobeika
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
B cell antigen receptor (BCR) signaling is a key driver of growth and survival in both normal and malignant B cells. Several lines of evidence support an important pathogenic role of the BCR in chronic lymphocytic leukemia (CLL). The significant impr
Externí odkaz:
https://doaj.org/article/2bd4afbf33b645ff81da7c92582150f8
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 9, p 4962 (2024)
B cell receptor-associated protein 31 (BAP31) is a transmembrane protein that is widely expressed and primarily located in the endoplasmic reticulum (ER). B cells play a crucial role in the immune system, and BAP31 significantly contributes to the fu
Externí odkaz:
https://doaj.org/article/12a35c2b4f6e4a90bc8cdf818f8f1219
Autor:
Liao Wang, Yinghui Sun, Xijie Liu, Hongjuan Li, Chang Lu, Ronghui Yang, Chuanzhen Yang, Binghui Li
Publikováno v:
Cancer Biology & Medicine, Vol 19, Iss 7, Pp 995-1007 (2022)
Objective: B-cell antigen receptor (BCR) signaling is required to maintain the physiological functions of normal B cells and plays an important pathogenic role in B-cell malignancies. Bruton tyrosine kinase (BTK), a critical mediator of BCR signaling
Externí odkaz:
https://doaj.org/article/3b5527f463474d5cac26cef0309bf887
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 1, p 10 (2023)
B-cell receptor (BCR) is a B cell hallmark surface complex regulating multiple cellular processes in normal as well as malignant B cells. Igα (CD79a)/Igβ (CD79b) are essential components of BCR that are indispensable for its functionality, signal i
Externí odkaz:
https://doaj.org/article/e3a7a894ab3f4fb48832e826473016d4
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Evolution of TP53 abnormalities during CLL disease course is associated with telomere length changes
Autor:
Helena Olbertova, Karla Plevova, Sarka Pavlova, Jitka Malcikova, Jana Kotaskova, Kamila Stranska, Michaela Spunarova, Martin Trbusek, Veronika Navrkalova, Barbara Dvorackova, Nikola Tom, Karol Pal, Marie Jarosova, Yvona Brychtova, Anna Panovska, Michael Doubek, Sarka Pospisilova
Publikováno v:
BMC Cancer, Vol 22, Iss 1, Pp 1-11 (2022)
Abstract Background Telomeres are protective structures at chromosome ends which shorten gradually with increasing age. In chronic lymphocytic leukemia (CLL), short telomeres have been associated with unfavorable disease outcome, but the link between
Externí odkaz:
https://doaj.org/article/62c7fe3bce37456bb78f5e4434870ef7