BNIP3 induction by hypoxia stimulates FASN-dependent free fatty acid production enhancing therapeutic potential of umbilical cord blood-derived human mesenchymal stem cells

Autor: So Hee Ko, Hyun Jik Lee, Sang Hun Lee, Gee Euhn Choi, Young Hyun Jung, Ho Jae Han, Sei Jung Lee

Publikováno v: Redox Biology, Vol 13, Iss C, Pp 426-443 (2017)
Redox Biology

Mitophagy under hypoxia is an important factor for maintaining and regulating stem cell functions. We previously demonstrated that fatty acid synthase (FASN) induced by hypoxia is a critical lipid metabolic factor determining the therapeutic efficacy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed303408c6659c26ed4800f3e9bf3d49
https://doi.org/10.1016/j.redox.2017.07.004

Different molecular mechanisms involved in spontaneous and oxidative stress-induced mitochondrial fragmentation in tripeptidyl peptidase-1 (TPP-1)-deficient fibroblasts

Autor: Michel Jadot, Guillaume Van Beersel, Thierry Arnould, Stéphane Demine, Isabelle Hamer, Eliane Tihon

Publikováno v: Bioscience Reports
Bioscience Reports, Vol 33, Iss 2, p e00023 (2013)
Van Beersel, G, Tihon, E, Demine, S, Hamer, I, Jadot, M & Arnould, T 2013, ' Different molecular mechanisms involved in spontaneous and oxidative stress-induced mitochondrial fragmentation in tripeptidyl peptidase-1 (TPP-1)-deficient fibroblasts ', Bioscience reports, vol. 33, no. 2, pp. 243-258 . https://doi.org/10.1042/BSR20120104

NCLs (neuronal ceroid lipofuscinoses) form a group of eight inherited autosomal recessive diseases characterized by the intralysosomal accumulation of autofluorescent pigments, called ceroids. Recent data suggest that the pathogenesis of NCL is assoc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87c54b7c094946370b901c693b32d16d
http://europepmc.org/articles/PMC3566540

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