Výsledky vyhledávání - "Bcl-2 gene family"

Genome-wide identification and expression analysis of Bcl-2 gene family under low-temperature stress in tilapia (Oreochromis niloticus)

Autor: Juan Tian, Changgeng Yang, Meizi Wang, Hua Wen, Xing Lu, Ming Jiang

Publikováno v: Israeli Journal of Aquaculture - Bamidgeh. 72

Low temperature stress can lead to variety of changes, including apoptosis in tilapia (Oreochromis niloticus). The B cell lymphoma-2 (Bcl-2) gene family plays an important role in the process of apoptosis. The present study conducted genome-wide char

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fba885ced334ac8a2ea1eca40c9e212c
https://doi.org/10.46989/001c.21307

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The peroxisomes strike BAK: Regulation of peroxisome integrity by the Bcl-2 family

Autor: Mark P.A. Luna-Vargas, Jerry E. Chipuk

Publikováno v: The Journal of Cell Biology

Chipuk and Luna-Vargas discuss Hosoi et al.’s study revealing conserved regulation of mitochondrial and peroxisome membrane permeabilization by the Bcl2 family.
Within the mitochondrial pathway of apoptosis, VDAC2 controls both the localizatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f81dd8447c82d3e4686c6c2563e340a
https://doi.org/10.1083/jcb.201701187

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Non-canonical roles of Bcl-2 and Bcl-xL proteins: Relevance of BH4 domain

Autor: Daniela Trisciuoglio, Chiara Gabellini, Donatella Del Bufalo

Publikováno v: Carcinogenesis (N.Y., Print) 38 (2017): 579–587. doi:10.1093/carcin/bgx016
info:cnr-pdr/source/autori:Gabellini, Chiara; Trisciuoglio, Daniela; Bufalo, Donatella Del/titolo:Non-canonical roles of Bcl-2 and Bcl-xL proteins: Relevance of BH4 domain/doi:10.1093%2Fcarcin%2Fbgx016/rivista:Carcinogenesis (N.Y., Print)/anno:2017/pagina_da:579/pagina_a:587/intervallo_pagine:579–587/volume:38

Bcl-2 protein family is constituted by multidomain members originally identified as modulators of programmed cell death and whose expression is frequently misbalanced in cancer cells. The lead member Bcl-2 and its homologue Bcl-xL proteins are charac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4804dbfb6dee4f232bd11d10c477483f
https://hdl.handle.net/11568/965214

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EXTH-55. CONCOMITANT INHIBITION OF RAC1 AND Bcl-2/Bcl-xL INTERFERES WITH THE Mcl-1/Usp9X AXIS AND YIELDS SYNERGISTIC ANTI-GLIOMA ACTIVITY

Autor: Michal Hlavac, Jens Engelke, Markus D. Siegelin, Christian Rainer Wirtz, Annika Dwucet, Richard E. Kast, Mike-Andrew Westhoff, Marc-Eric Halatsch, Georg Karpel-Massler

Publikováno v: Neuro-Oncology. 20:vi96-vi97

The purpose of this study was to examine whether inhibition of RAC1 would enhance the pro-apoptotic reprogramming of glioblastoma’s cellular circuitry following selective Bcl-2/Bcl-xL inhibition by BH-3 mimetics. Preclinical drug testing and molecu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af54595db0b0f3f3bcbcc52a0e965faa
https://doi.org/10.1093/neuonc/noy148.403

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MCL-1 Inhibitor-Induced Killing of Multiple Myeloma Is Modulated By the Relative Level of Expression of Pro-Survival Members of the BCL-2 Family and the Proto-Oncogene MYC

Autor: Tiffany Khong, Andrew Spencer, Maoshan Chenn

Publikováno v: Blood. 134:1825-1825

Background: The anti-apoptotic protein Myeloid cell leukemia sequence 1 (MCL-1) is involved in the regulation of programmed cell death and is highly expressed in multiple myeloma (MM) playing an important role in promoting the survival of MM cells. R

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8f24d79db2cf8bac40c12f6995fc5731
https://doi.org/10.1182/blood-2019-127843

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The Proapoptotic BH3-Only, Bcl-2 Family Member, Puma Is Critical for Acute Ethanol-Induced Neuronal Apoptosis

Autor: Barbara J. Klocke, Kevin A. Roth, Andreas Strasser, Arindam P. Ghosh, Rune Toms, Ken C. Walls

Publikováno v: Journal of Neuropathology & Experimental Neurology. 68:747-756

Synaptogenesis in humans occurs in the last trimester of gestation and in the first few years of life, whereas it occurs in the postnatal period in rodents. A single exposure of neonatal rodents to ethanol during this period evokes extensive neuronal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::847eaacc75d733fb19b7914857b7f659
https://doi.org/10.1097/nen.0b013e3181a9d524

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Bax activation by the BH3-only protein Puma promotes cell dependence on antiapoptotic Bcl-2 family members

Autor: John A. Hickman, Olivier Geneste, Stéphen Manon, Philippe Juin, Belinda Noël, Pierre-François Cartron, Tristan Gallenne, Eric Hervouet, François M. Vallette, Lisa Oliver, Fabien Gautier

Publikováno v: Journal of Cell Biology. 185:279-290

It is still unclear whether the BH3-only protein Puma (p53 up-regulated modulator of apoptosis) can prime cells to death and render antiapoptotic BH3-binding Bcl-2 homologues necessary for survival through its ability to directly interact with proapo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9e9c28f19360dddee34318bdc482dadd
https://doi.org/10.1083/jcb.200809153

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Bcl-xL Forms Two Distinct Homodimers at Non-ionic Detergents: Implications in the Dimerization of Bcl-2 Family Proteins

Autor: Yu Feng, Hualiang Jiang, Xu Shen, Zhaohu Lin, Dongxiang Liu, Kaixian Chen

Publikováno v: The Journal of Biochemistry. 143:243-252

As the key regulator of apoptosis, Bcl-2 family protein controls the cell death by forming homo- or heterodimers among anti-apoptotic and pro-apoptotic members of this family. Here we have studied Bcl-x(L) homodimerization at different pH in the pres

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7711a7f33f808bc6ecec6a9fdd79829
https://doi.org/10.1093/jb/mvm216

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