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of 9 826
pro vyhledávání: '"Bcl-2 family"'
Autor:
Lisa Nocquet, Julie Roul, Chloé C. Lefebvre, Laurine Duarte, Mario Campone, Philippe P. Juin, Frédérique Souazé
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract Triple negative breast cancers (TNBC) present a poor prognosis primarily due to their resistance to chemotherapy. This resistance is known to be associated with elevated expression of certain anti-apoptotic members within the proteins of the
Externí odkaz:
https://doaj.org/article/9bf835edf7ef4f71a415194da190628a
Publikováno v:
Advances in Cancer Biology - Metastasis, Vol 11, Iss , Pp 100126- (2024)
Colorectal cancer (CRC) remains a significant global health challenge, with an alarming upward trend in Asia. Early detection is crucial for improving outcomes, but there is no consensus on the optimal screening approach. Despite advances in diagnosi
Externí odkaz:
https://doaj.org/article/84d7910afe8c458fb9286815160f04b8
Autor:
Faris Tayeb
Publikováno v:
Exploration of Medicine, Vol 5, Iss 3, Pp 331-350 (2024)
During cellular stress, the master regulators of intrinsic self-death (apoptosis) are BCL-2 family proteins. The BCL-2 family proteins play a key role in apoptosis and are tightly regulated via other BCL-2 family proteins, non-BCL-2 protein suppresso
Externí odkaz:
https://doaj.org/article/dba9fce0ef934c989f0e9a3665efd5d1
Akademický článek
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Autor:
Md. Saddam, Shamrat Kumar Paul, Mohammad Ahsan Habib, Md. Abrar Fahim, Afsana Mimi, Saiful Islam, Bristi Paul, Md Mostofa Uddin Helal
Publikováno v:
Egyptian Journal of Medical Human Genetics, Vol 25, Iss 1, Pp 1-28 (2024)
Abstract Apoptosis, also known as the programmed death of cells, is responsible for maintaining the homeostasis of tissues, and this function is carried out by caspases. The process of apoptosis is carried out via two distinct pathways: the extrinsic
Externí odkaz:
https://doaj.org/article/92291bc9da47422cb27b36f1b508e013
Publikováno v:
Arthritis Research & Therapy, Vol 25, Iss 1, Pp 1-13 (2023)
Abstract Objective This study aimed to evaluate the expression level of anti-apoptotic Bcl-2 family proteins in B and T cells in patients with systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) in relation to disease activity and the ef
Externí odkaz:
https://doaj.org/article/e075aa1cb99049cc9e2351fbe28982c3
Publikováno v:
Biology Direct, Vol 18, Iss 1, Pp 1-7 (2023)
Abstract Bcl-B is a poorly understood protein of the Bcl-2 family that is highly expressed in many healthy tissues and tumor types. Bcl-B is considered an antiapoptotic protein, but many reports have revealed its contradictory roles in different canc
Externí odkaz:
https://doaj.org/article/b975518a6d35405b85867bc0aa088ab7
Autor:
Ibrahim Damilare Boyenle, Abdeen Tunde Ogunlana, Abdul-Quddus Kehinde Oyedele, Babatunde Kazeem Olokodana, Nurudeen Owolabi, Abdulmalik Salahudeen, Oluwafemi Timothy Aderenle, Taiwo Oluwafisayomi Oloyede, Temitope Isaac Adelusi, PhD
Publikováno v:
Journal of Taibah University Medical Sciences, Vol 18, Iss 3, Pp 461-469 (2023)
الملخص: أهداف البحث: في حين أن التوازن الدقيق في أفراد الأسرة المؤيدة للاستماتة والمضاد للاستماتة من عائلة بروتين الخلايا البائية 2 (بي سي
Externí odkaz:
https://doaj.org/article/e3080b9a970b4680892703113f379063
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 21, Iss , Pp 3760-3767 (2023)
The apoptotic pathway is regulated by protein-protein interactions between members of the Bcl-2 family. Pro-survival Bcl-2 family proteins act as cell guardians and protect cells against death. Selective binding and neutralization of BH3-only protein
Externí odkaz:
https://doaj.org/article/d8c3b60ff92a44deab6724b2aa49f857
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Diverse developmental signals and pro-death stresses converge on the regulation of the mitochondrial pathway of apoptosis. BAX, a proapoptotic BCL-2 effector, directly forms proteolipid pores in the outer mitochondrial membrane to activate the mitoch
Externí odkaz:
https://doaj.org/article/ad1c5e974e5b4f44951c3ad2fc7fdb0e